Results 51 to 60 of about 1,222,014 (285)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Molecular evidence for ongoing complementarity and horizontal gene transfer in endosymbiotic systems of mealybugs [PDF]

, 2014
Intracellular bacterial supply of essential amino acids is common among sap-feeding insects, thus complementing the scarcity of nitrogenous compounds in plant phloem. This is also the role of the two mealybug endosymbiotic systems whose genomes have been
Altschul, Amann, Baumann, Baumann, Charles, Cox, Darriba, Duron, Felsenstein, Fukatsu, Gatehouse, Gil, Gruwell, Guindon, Hardy, Husnik, Koga, Kono, Larkin, Littlewood, Lopez-Madrigal, Lopez-Madrigal, McCutcheon, McCutcheon, Moran, Moya, Moya, Mühling, Nakabachi, Pellizzari, Ronquist, Rosenblueth, Rutherford, Staden, Stamatakis, Thao, van Ham, von Dohlen   +37 more
core   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A folding inhibitor of the HIV-1 Protease

, 2005
Being the HIV-1 Protease (HIV-1-PR) an essential enzyme in the viral life cycle, its inhibition can control AIDS. The folding of single domain proteins, like each of the monomers forming the HIV-1-PR homodimer, is controlled by local elementary ...
Abkevich, Andrade, Baldwin, Broglia, Broglia, Broglia, Broglia, D. Provasi, F. Vasile, G. Ottolina, G. Tiana, Hansen, Haspel, Ishima, Ishima, Karplus, Lesk, Leuthardt, Levy, Louis, Louis, Maritan, Panchenko, R. A. Broglia, R. Longhi, Richards, Srinivasan, Tiana, Tiana, Tiana, Todd, Tomasselli, Tomaszek, Wallqvist, Xie, Yamazaki   +35 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Considerations on amino acid patterns in the natural felid diet: a review

Frontiers in Veterinary Science
Amino acids are essential for the growth, development, and reproduction of carnivores. This literature review summarizes the amino acid patterns of different raw diets including whole prey, body tissue and muscle for felids under human care.
Mengmeng Sun, Annelies De Cuyper, Ellen S. Dierenfeld, Geert P. J. Janssens   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analysis and comprehensive evaluation of amino acid composition of Coreopsis tinctoria from different habitats

Shipin yu jixie, 2022
Objective: This study focuses on in-depth research and development of the utilization of Coreopsis tinctoria resources. Methods: The Coreopsis samples from Hetian, Urumqi, Aba, Luding and Xining were hydrolyzed with hydrochloric acid, and the contents of
LU Qing-yao, ZHOU Min, ZHOU Hui-ling, JIAO Shi-rong   +3 more
doaj   +1 more source

Amino acid and fatty acid profile of twenty wild plants used as spices in Cameroon [PDF]

, 2016
The amino acids and fatty acids of twenty wild plants used as spices which were collected in Cameroon were investigated. The most important of total non-essential amino acids (TNEAA) contents have been found in A. daniellii (52.04%), C. frutescens (50.53%
Abdou Bouba, Armand, Abul-Hamd El-Sayed, Mehanni, Augustin, Goudoum, Mbofung, Carl Moses, Montet, Didier, Njintang Yanou, Nicolas, Ponka, Roger, Scher, Joel   +7 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source