Results 1 to 10 of about 61,455 (226)

Role of insulin-regulated aminopeptidase as potential biomarker in insulin resistant polycystic ovary syndrome patients [PDF]

Archives of Endocrinology and Metabolism
Objective: To measure serum insulin-regulated aminopeptidase levels in women diagnosed with polycystic ovary syndrome and to investigate their potential contribution of these levels to the development of insulin resistance, which plays a central role in ...
Osman Köse, Koray Gök, Elif Köse, Sezen Irmak Gözükara, Abdullah Tüten, Mehmet Sühha Bostancı   +5 more
doaj   +3 more sources

Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds [PDF]

Pharmaceuticals, 2019
The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and barley seed aminopeptidase was determined experimentally.
Weronika Wanat, Michał Talma, Małgorzata Pawełczak, Paweł Kafarski   +3 more
doaj   +3 more sources

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

eLife, 2022
Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world.
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward   +14 more
doaj   +1 more source

A cathepsin C-like protease mediates the post-translation modification of Toxoplasma gondii secretory proteins for optimal invasion and egress

mBio, 2023
Microbial pathogens use proteases for their infections, such as digestion of proteins for nutrients and activation of their virulence factors. As an obligate intracellular parasite, Toxoplasma gondii must invade host cells to establish its intracellular ...
L. Brock Thornton, Melanie Key, Chiara Micchelli, Andrew J. Stasic, Samuel Kwain, Katherine Floyd, Silvia N.J. Moreno, Brian N. Dominy, Daniel C. Whitehead, Zhicheng Dou   +9 more
doaj   +1 more source

A New L-Proline Amide Hydrolase with Potential Application within the Amidase Process

Crystals, 2021
L-proline amide hydrolase (PAH, EC 3.5.1.101) is a barely described enzyme belonging to the peptidase S33 family, and is highly similar to prolyl aminopeptidases (PAP, EC. 3.4.11.5).
Sergio Martinez-Rodríguez, Rafael Contreras-Montoya, Jesús M. Torres, Luis Álvarez de Cienfuegos, Jose Antonio Gavira   +4 more
doaj   +1 more source

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families

Marine Drugs, 2023
Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes.
Isel Pascual Alonso, Fabiola Almeida García, Mario Ernesto Valdés Tresanco, Yarini Arrebola Sánchez, Daniel Ojeda del Sol, Belinda Sánchez Ramírez, Isabelle Florent, Marjorie Schmitt, Francesc Xavier Avilés   +8 more
doaj   +1 more source

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities

Frontiers in Immunology, 2022
IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban, Adrian Martín-Esteban, Jesus Contreras Rodriguez, David Peske, Jose A. Lopez de Castro, Nilabh Shastri, Scheherazade Sadegh-Nasseri   +6 more
doaj   +1 more source

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation

Frontiers in Immunology, 2022
Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou, Anastasia Mpakali, Efstratios Stratikos, Efstratios Stratikos   +3 more
doaj   +1 more source

Proteases as Therapeutic Targets Against the Parasitic Cnidarian Ceratonova shasta: Characterization of Molecules Key to Parasite Virulence In Salmonid Hosts

Frontiers in Cellular and Infection Microbiology, 2022
Proteases and their inhibitors play critical roles in host-parasite interactions and in the outcomes of infections. Ceratonova shasta is a myxozoan pathogen that causes enteronecrosis in economically important salmonids from the Pacific Northwest of ...
Gema Alama-Bermejo, Gema Alama-Bermejo, Pavla Bartošová-Sojková, Stephen D. Atkinson, Astrid S. Holzer, Jerri L. Bartholomew   +5 more
doaj   +1 more source

The role of insulin-regulated aminopeptidase in MHC class I antigen presentation

Frontiers in Immunology, 2012
Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
doaj   +1 more source