Results 11 to 20 of about 61,455 (226)

MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae [PDF]

Open Biology, 2013
Bacterial aminopeptidases play important roles in pathogenesis by providing a source of amino acids from exogenous proteins, destroying host immunological effector peptides and executing posttranslational modification of bacterial and host proteins.
Mark W. Robinson, Kyle A. Buchtmann, Cheryl Jenkins, Jessica L. Tacchi, Benjamin B. A. Raymond, Joyce To, Piklu Roy Chowdhury, Lauren K. Woolley, Maurizio Labbate, Lynne Turnbull, Cynthia B. Whitchurch, Matthew P. Padula, Steven P. Djordjevic   +12 more
doaj   +1 more source

Preparation and Characterization of an Ancient Aminopeptidase Obtained from Ancestral Sequence Reconstruction for L-Carnosine Synthesis

Molecules, 2022
As a biologically active peptide, L-carnosine has been widely used in the pharmaceutical, cosmetic and health care industries due to its various physiological properties.
Fan Liu, Yi Shi, Yakun Fang, Zhenshan Liu, Yu Xin, Zhenghua Gu, Zitao Guo, Liang Zhang   +7 more
doaj   +1 more source

The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review

Frontiers in Pharmacology, 2020
Insulin-Regulated Aminopeptidase (IRAP, EC 3.4.11.3) is a multi-tasking member of the M1 family of zinc aminopeptidases. Among its diverse biological functions, IRAP is a regulator of oxytocin levels during late stages of pregnancy, it affects cellular ...
Dimitris Georgiadis, Angeliki Ziotopoulou, Eleni Kaloumenou, Angelos Lelis, Antonia Papasava   +4 more
doaj   +1 more source

Fungal Traits Important for Soil Aggregation [PDF]

, 2020
Soil structure, the complex arrangement of soil into aggregates and pore spaces, is a key feature of soils and soil biota. Among them, filamentous saprobic fungi have well-documented effects on soil aggregation. However, it is unclear what properties, or
Lehmann, Anika, Maß, Stefanie, Rillig, Matthias C., Rongstock, Rebecca, Roy, Julien, Ryo, Masahiro, Soutschek, Katharina, Zheng, Weishuang   +7 more
core   +1 more source

Depth-Resolved Variations of Cultivable Bacteria and Their Extracellular Enzymes in the Water Column of the New Britain Trench

Frontiers in Microbiology, 2018
Marine microorganisms and their extracellular enzymes (ECEs) play an important role in the remineralization of organic material by hydrolyzing high-molecular-weight substrates to sizes sufficiently small to be transported through cell membrane, yet the ...
Qianfeng Liu, Jiasong Fang, Jiasong Fang, Jiasong Fang, Jiangtao Li, Li Zhang, Bin-Bin Xie, Xiu-Lan Chen, Yu-Zhong Zhang, Yu-Zhong Zhang   +9 more
doaj   +1 more source

An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection

Microorganisms, 2020
Aminopeptidases that catalyze the removal of N-terminal residues from polypeptides or proteins are crucial for physiological processes. Here, we explore the biological functions of an M29 family aminopeptidase II from Listeria monocytogenes (LmAmpII). We
Xian Zhang, Chiyu Guan, Yi Hang, Fengdan Liu, Jing Sun, Huifei Yu, Li Gan, Huan Zeng, Yiran Zhu, Zhongwei Chen, Houhui Song, Changyong Cheng   +11 more
doaj   +1 more source

Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]

, 2003
Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P., Holz, Richard C., Swierczek, Sabina I.   +2 more
core   +2 more sources

IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells

Frontiers in Cell and Developmental Biology, 2020
Dendritic cells (DCs) contribute to the immune surveillance by sampling their environment through phagocytosis and endocytosis. We have previously reported that, rapidly following uptake of extracellular antigen into phagosomes or endosomes in DCs, a ...
Mirjana Weimershaus, François-Xavier Mauvais, Irini Evnouchidou, Irini Evnouchidou, Myriam Lawand, Loredana Saveanu, Peter van Endert   +6 more
doaj   +1 more source

Aminopeptidase C of Aspergillus niger is a Novel Phenylalanine Aminopeptidase [PDF]

, 2003
A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share ...
Basten, E.J.W., Dekker, P.J.T., Schaap, P.J.   +2 more
core   +2 more sources

Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain

Frontiers in Molecular Biosciences, 2020
Placental leucine aminopeptidase/insulin-regulated aminopeptidase (P-LAP/IRAP) regulates vasopressin and oxytocin levels in the brain and peripheral tissues by controlled degradation of these peptides.
Yoshikuni Goto, Takahiro J. Nakamura, Kenji Ogawa, Akira Hattori, Masafumi Tsujimoto   +4 more
doaj   +1 more source