Functional characterization of two M42 aminopeptidases erroneously annotated as cellulases. [PDF]
PLoS ONE, 2012 Several aminopeptidases of the M42 family have been described as tetrahedral-shaped dodecameric (TET) aminopeptidases. A current hypothesis suggests that these enzymes are involved, along with the tricorn peptidase, in degrading peptides produced by the ...
Raphaël Dutoit +3 more
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Aminopeptidasic Enzymes as Early Biomarkers of Cardiac Surgery-Associated Acute Kidney Injury and Long-Term Events [PDF]
BiomoleculesBackground: Diagnosis of acute kidney injury (AKI) relies on serum creatinine (SCr) changes. This study investigated if urinary aminopeptidases are early and predictive biomarkers of cardiac surgery-associated AKI (CSA-AKI).
Noelia Rísquez Chica +6 more
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Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds [PDF]
Pharmaceuticals, 2019 The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and barley seed aminopeptidase was determined experimentally.
Weronika Wanat +3 more
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Agricultural & Environmental Letters, 2022 Aminopeptidases are one of the extracellular hydrolytic enzymes that catalyze organic nitrogen (N) depolymerization and are commonly assayed using fluorogenic substrates.
Andrew J Margenot, Rachel C Daughtridge
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Foods, 2023 A total of 26 lactic acid bacteria isolates from both Italian and Brazilian cheeses were tested for their use in cheesemaking. Isolates were screened for salt tolerance, exopolysaccharide and diacetyl production, lipolytic, acidifying, and proteolytic ...
Fabrizio Domenico Nicosia +6 more
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Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. [PDF]
PLoS ONE, 2012 Plasmodium falciparum, the causative agent of human malaria, expresses two aminopeptidases, PfM1AAP and PfM17LAP, critical to generating a free amino acid pool used by the intraerythrocytic stage of the parasite for proteins synthesis, growth and ...
Marcin Poreba +9 more
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The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease
Frontiers in Immunology, 2020 In the human genome, the aminopeptidases ERAP1, ERAP2 and LNPEP lie contiguously on chromosome 5. They share sequence homology, functions and associations with immune-mediated diseases.
Fabiana Paladini +4 more
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The Long-Term Study of Urinary Biomarkers of Renal Injury in Spontaneously Hypertensive Rats
Kidney & Blood Pressure Research, 2021 Background: The age-related increase in blood pressure in spontaneously hypertensive rats (SHRs) is associated to cardiac hypertrophy, heart failure, and renal injury.
Sebastián Montoro-Molina +8 more
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Cancer Medicine, 2020 Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide‐conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma.
Alexander Schepsky +11 more
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Geoderma, 2023 Aminopeptidases catalyze the hydrolysis of peptides into constituent amino acids and are therefore a key step in nitrogen (N) depolymerization and downstream mineralization. Differences in carbon (C):N as well as sulfur (S) content of amino acids present
Jasdeep Singh +3 more
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