Results 111 to 120 of about 13,303 (230)

Druggable genome‐wide Mendelian randomization analysis identifies potential treatment targets in vascular dementia

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract BACKGROUND There are currently no US Food and Drug Administration‐approved treatments for vascular dementia (VaD). Genome‐wide approaches have successfully identified druggable targets and treatments for various disorders. In this study, we performed druggable genome‐wide two‐sample Mendelian randomization (2SMR) analysis to identify possible ...
Matthew J. Lennon, Ying Xu, Anbupalam Thalamuthu, Karen Mather, Perminder S. Sachdev   +4 more
wiley   +1 more source

Interactive Effect of Residue Quality and Agroecologies Modulate Soil C- and N-Cycling Enzyme Activities, Microbial Gene Abundance, and Metabolic Quotient

Applied and Environmental Soil Science
Understanding interactive effect of agroecology explained by rainfall, temperature, elevation, and biochemical composition of residues on soil microbial abundance and functions is crucial for unraveling soil ecological processes.
Birhanu Agumas, Getachew Agegnehu, Tesfaye Feyisa   +2 more
doaj   +1 more source

Plant canopies sustain soil C‐N‐P enzyme activities under climatic disequilibrium

Journal of Ecology, Volume 114, Issue 4, April 2026.
Our findings reveal that plant–soil interactions are sensitive to mismatches between plant communities and climate. By enhancing enzymatic functioning under conditions of climatic disequilibrium, canopy plants contribute to maintaining nutrient cycling processes and potentially ecosystem resilience.
Jorge Prieto‐Rubio, Jordi Margalef‐Marrasé, Francisco Lloret, Marta Goberna, Ana Rincón, Miguel Verdú   +5 more
wiley   +1 more source

Analyzing the Catalytic Role of Asp97 in the Methionine Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]

, 2008
An active site aspartate residue, Asp97, in the methionine aminopeptidase (MetAPs) from Escherichia coli (EcMetAP-I) was mutated to alanine, glutamate, and asparagine.
Bennett, Brian, Holz, Richard C., Job, Kathleen M., Meng, Lu, Mitra, Sanghamitra   +4 more
core   +1 more source

“Steak Dry Aging”: An Innovative Approach to Producing High‐Yield, High‐Quality Dry‐Aged Beef

Journal of Food Science, Volume 91, Issue 4, April 2026.
ABSTRACT This study evaluated a novel steak dry‐aging (StDA) protocol in which portioned beef steaks were dry‐aged until reaching an average weight loss of 15% and subsequently wet‐aged to achieve a total aging time of either 14 or 28 days. The new protocol was compared with conventional dry aging (DA) for 28 days and unaged controls.
Jean Carlos dos Santos, Angélica Sousa Guimarães, Lethicia Olímpio Bueno, Lorrany Ramos do Carmo, Márcia Cristina Teixeira da Silveira, Alcinéia de Lemos Souza Ramos, Leandro Sâmia Lopes, Eduardo Mendes Ramos   +7 more
wiley   +1 more source

Inhibition of the Aminopeptidase from \u3cem\u3eAeromonas proteolytica\u3c/em\u3e by l-leucinethiol: Kinetic and Spectroscopic Characterization of a Slow, Tight-binding Inhibitor–enzyme Complex [PDF]

, 2000
The peptide inhibitor l-leucinethiol (LeuSH) was found to be a potent, slow-binding inhibitor of the aminopeptidase from Aeromonas proteolytica (AAP). The overall potency (KI*) of LeuSH was 7 nM while the corresponding alcohol l-leucinol (LeuOH) was a ...
Bennett, Brian, Bienvenue, David L., Holz, Richard C.   +2 more
core   +1 more source

Microbial Resistance and Resilience to Short‐Term Drought Varies Among Grasslands Spanning a Broad Precipitation Gradient

Grass and Forage Science, Volume 81, Issue 2, April-June 2026.
ABSTRACT Drought is increasing in severity and duration across the United States, particularly in arid and semi‐arid regions. Previous research has shown that drought has strong impacts in drier versus more mesic regions for aboveground productivity.
Leena L. Vilonen, Melinda D. Smith, Jing Yuan, Pankaj Trivedi   +3 more
wiley   +1 more source

Interferon Regulatory Factor 2 (IRF2) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion

Immunology, Volume 177, Issue 4, Page 752-765, April 2026.
Our data show that suppressing IRF2, genetically or by siRNA, modulates PD‐L1 and MHC‐I levels. This induced immune‐evasive state critically underlies the significantly prolonged survival of cardiac allografts, revealing a novel therapeutic avenue.
Li Tian, Man Zhang, Yuliang Guo, Sheng Chang, Zhonghua Klaus Chen, Hongmin Zhou   +5 more
wiley   +1 more source

Peri‐Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Disruption of astrocytic glycogen metabolism, induced by glycogen phosphorylase inhibition (DAB) or genetic deficiency of GYS1 (GYS1Nestin‐KO and GYS1Gfap‐KO), reduces lactate availability to pericytes and impairs microvascular function. This metabolic deficit leads to pericyte‐associated capillary constriction, reduced cerebral blood flow, and ...
Gokhan Uruk, Buket Donmez‐Demir, Sinem Yilmaz‐Ozcan, Canan Cakir‐Aktas, Aslihan Taskiran‐Sag, Gokce Gurler, Jordi Duran, Joan J. Guinovart, Otto Baba, Tsuyoshi Morita, Hulya Karatas, Turgay Dalkara, Muge Yemisci   +12 more
wiley   +1 more source

Secreted Proteases from Dermatophytes [PDF]

, 2018
Dermatophytes are highly specialized pathogenic fungi that exclusively infect the stratum corneum, nails or hair, and it is evident that secreted proteolytic activity is important for their virulence.
Monod, Michel
core