Results 91 to 100 of about 8,494 (234)

RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?

Frontiers in Immunology, 2019
Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and ...
Matteo Vecellio, Matteo Vecellio, Matteo Vecellio, Carla J. Cohen, Carla J. Cohen, Carla J. Cohen, Amity R. Roberts, Paul B. Wordsworth, Paul B. Wordsworth, Paul B. Wordsworth, Tony J. Kenna, Tony J. Kenna   +11 more
doaj   +1 more source

Diagnostic Biomarkers of Periodontitis and Peri‐Implantitis: The Past, the Present, the Future

Journal of Periodontal Research, EarlyView.
Diagnostic biomarkers of periodontitis and peri‐implantititis from the past, through the present, and into the future. ABSTRACT In this narrative review we present our perspective on the past, present and future of periodontal and peri‐implantitis diagnostic biomarkers.
Denis F. Kinane, Başak Bıyıkoğlu
wiley   +1 more source

Aminopeptidases and dipeptidyl-peptidases secreted by the dermatophyte Trichophyton rubrum

, 2005
The nature of secreted aminopeptidases in Trichophyton rubrum was investigated by using a reverse genetic approach. T. rubrum genomic and cDNA libraries were screened with Aspergillus spp.
Monod M, Grouzmann, E., Zaugg C, Léchenne B, Grand, D., Zaugg, C., Monod, M., Stöcklin R, Lechenne, B., Jousson O, Jousson, O., Grouzmann E, Stocklin, R., Grand D   +13 more
core   +1 more source

Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia

Oral Diseases, EarlyView.
ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio, Divya Ganesh, Bishwa Prakash Bhattarai, Tine Merete Søland, Jonas Sundberg, Annika Thorsell, Jenny Öhman, Dipak Sapkota, Bengt Hasséus   +8 more
wiley   +1 more source

Beneath the Drought: Rhizosphere Processes Shape Genotype‐Specific Sorghum Responses to Drought‐Induced N Limitation

Plant, Cell &Environment, EarlyView.
ABSTRACT Droughts increasingly threaten crop productivity in nutrient‐depleted tropical soils. We investigated how water limitation influences rhizomicrobial traits (microbial biomass and functional community composition, enzyme activities) and nitrogen (N) uptake in three sorghum genotypes Makueni local (Mkl), Gadam (Gd), and IESH 22012 (IESH) under ...
Rosepiah Munene, Osman Mustafa, Sara Loftus, Vincent O. Suba, Nipuna Withanage, Niklas Schmücker, Peter Bulli, Reimund P. Rötter, Dennis O. Otieno, Mutez A. Ahmed, Michaela A. Dippold   +10 more
wiley   +1 more source

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

Frontiers in Immunology, 2017
Antigenic peptides presented by the major histocompatibility complex class I (MHC-I) molecules for recognition by cytotoxic T-lymphocytes are processed by members of the oxytocinase sub-family of M1 aminopeptidases ERAP1, ERAP2, and IRAP.
Athanasios Papakyriakou, Athanasios Papakyriakou, Efstratios Stratikos   +2 more
doaj   +1 more source

Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin

Plant, Cell &Environment, EarlyView.
ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski, Agnieszka J. Pietrzyk‐Brzezinska, Aleksandra Twarda‐Clapa, Bartosz Sekula   +3 more
wiley   +1 more source

Antigenic peptide trimming by ER aminopeptidases--insights from structural studies

, 2015
Generation and destruction of antigenic peptides by ER resident aminopeptidases ERAP1 and ERAP2 have been shown in the last few years to be important for the correct functioning and regulation of the adaptive immune response.
Stratikos, Efstratios, Stern, Lawrence J.   +1 more
core   +1 more source

CHANGES IN LEVELS OF ACTIVITY OF SERINE PROTEASES ACCOMPANY THE EXPOSURE OF COMMON BEAN (PHASEOLUS VULGARIS L.) TO WATER DEFICIT [PDF]

Poljoprivreda, 2008
A wide variety of proteolytic enzymes exist in plants. On their levels depends protein turnover, a fundamental component in plant development and adaptation to environmental conditions. Cysteine proteases have frequently been reported to be influenced by
M. Budič, M. Šoštarič, B. Cigić, M. Kidrič, V. Meglič   +4 more
doaj  

Microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Objectives To critically evaluate the current evidence on microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases, with emphasis on their biological relevance, potential clinical utility, and current translational limitations.
Su Sheng Quach, Ausra Ramanauskaite, Sašo Ivanovski, Pingping Han, Frank Schwarz, Emilio A. Cafferata   +5 more
wiley   +1 more source