Results 81 to 90 of about 8,494 (234)

Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros.

PLoS Neglected Tropical Diseases, 2010
BackgroundSnake bite is a major neglected public health issue within poor communities living in the rural areas of several countries throughout the world. An estimated 2.5 million people are bitten by snakes each year and the cost and lack of efficacy of
Sakthivel Vaiyapuri, Simon C Wagstaff, Kimberley A Watson, Robert A Harrison, Jonathan M Gibbins, E Gail Hutchinson   +5 more
doaj   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

TRIM59 Drives Bladder Cancer Progression Through E3 Ligase‐Dependent K48‐Linked Degradation of PTRF

Cancer Science, EarlyView.
Schematic model of TRIM59‐driven BLCA progression through K48‐linked ubiquitination and proteasomal degradation of PTRF, leading to AKT activation and c‐Myc upregulation. ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood ...
Junlin Gan, Xuesong Bai, Aijie Zhang, Fei Lin, Hang Tong, Tinghao Li, Ning Xu, Xinyuan Li, Zhou Yu, Hubin Yin   +9 more
wiley   +1 more source

Histochemical investigations on aminopeptidases in Artemia salina (Phyllopoda) embryos and larvae.

, 1980
Pre-strctural localization of enzymes during embryonic development was studied by the localization of aminopeptidases ...
FALUGI, CARLA
core   +1 more source

Structural features of ZAK kinase regulation at the ribosome

The FEBS Journal, EarlyView.
ZAK kinase binds ribosomes in various states (hibernating, translating, and colliding). Widespread ribosome collisions promote ZAK autophosphorylation and activation of the ribotoxic stress response pathway. This stress signaling pathway mediates downstream cell fate decisions such as cell cycle arrest and apoptosis. ZAKα is a MAP3K that interacts with
Shuangshuang Niu, Vienna L. Huso, Roland Beckmann, Rachel Green   +3 more
wiley   +1 more source

Pemafibrate Improves Cholestatic Markers Regardless of the Presence of Primary Biliary Cholangitis

Hepatology Research, EarlyView.
Pemafibrate improves liver function markers related to bile flow in primary biliary cholangitis (PBC), but whether this effect is disease‐specific remains unclear. In this study, pemafibrate reduced these markers in patients with and without PBC, suggesting broader effects on bile flow beyond PBC.
Ryohei Tanigawa, Yoshiyuki Ueno, Hirokazu Takahashi, Ayumi Saito, Hideki Suganami, Atsushi Tanaka   +5 more
wiley   +1 more source

A comparison of aminopeptidases from excised human buccal epithelium and primary cultures of hamster pouch buccal epithelium

, 1991
Aminopeptidase activity associated with human buccal tissue and primary cultures of hamster buccal epithelium homogenates was assayed fluorometrically using 4-methoxy-2-naphthyl-amides of leucine, alanine, and arginine.
Amos Williams, M Reza Tavakoli-Saberi, Kenneth L Audus   +2 more
core   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases

, 2014
Endosplasmic reticulum aminopeptidase 1 (ERAP1), endoplasmic reticulum aminopeptidase 2 (ERAP2) and puromycin-sensitive aminopeptidase (NPEPPS) are key zinc metallopeptidases that belong to the oxytocinase subfamily of M1 aminopeptidase family.
Brown, M.A., Agrawal, N., Brown, M. A.
core   +1 more source

M1 aminopeptidases as drug targets:Broad applications or therapeutic niche? [PDF]

, 2017
M1 aminopeptidase enzymes are a diverse family of metalloenzymes characterized by conserved structure and reaction specificity. Excluding viruses, M1 aminopeptidases are distributed throughout all phyla, and have been implicated in a wide range of ...
McGowan, Sheena, Wei Yang, Nyssa Drinkwater, Jisook Lee, Lee, Jisook, Sheena McGowan, Tess R. Malcolm, Drinkwater, Nyssa, Yang, Wei, Malcolm, Tess R.   +9 more
core   +1 more source