Results 61 to 70 of about 6,497 (198)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

N-Benzyl Residues as the P1′ Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases

Molecules, 2020
Peptidyl enzyme inhibitors containing an internal aminomethylphosphinic bond system (P(O)(OH)-CH2-NH) can be termed extended transition state analogs by similarity to the corresponding phosphonamidates (P(O)(OH)-NH).
Kamila Janiszewska, Michał Talma, Bartosz Oszywa, Małgorzata Pawełczak, Paweł Kafarski, Artur Mucha   +5 more
doaj   +1 more source

Bt agave: why it is time to explore a new biotechnological frontier

Pest Management Science, EarlyView.
Drylands cover 41% of Earth, requiring sustainable crops. Agave, drought‐ and heat‐adapted, offers high‐value products with low water needs. Pests limit yield, yet Bacillus thuringiensis (Bt) Cry proteins, successful in other plants, remain unexploited in Agave.
Aline Vitória Corim Marim, Marcelo Falsarella Carazzolle, Gonçalo Amarante Guimarães Pereira, Carolina Rossi De Oliveira   +3 more
wiley   +1 more source

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Frontiers in Pharmacology, 2020
The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders.
Nicholas Barlow, Philip E. Thompson
doaj   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Degradable versus inert microplastics: Effects on soil organic carbon persistence via microbial drivers in an agroecosystem

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Microplastics (MPs) are widespread in terrestrial ecosystems, raising global concerns that they may disrupt soil organic carbon (SOC) cycling and undermine agroecosystem contributions to climate mitigation.
Meng‐Ying Li, Wei Wang, Yue Ma, Jia‐Yao Yang, Shu‐Tong Liu, Xiao‐Bin Xiong, Tingting Zhao, Yuanze Sun, Saddam Saqib, Muhammd Ashraf, Matthias C. Rillig, You‐Cai Xiong   +11 more
wiley   +1 more source

Bio‐organic fertilizer alleviated soil microbial C limitations, aggravated P limitations and increased microbial C use efficiency in a degraded desert steppe

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Bio‐organic fertilizer (BOF), which integrates organic carbon sources, beneficial microorganisms and essential nutrients, represents a distinctive approach to grassland restoration that differs fundamentally from conventional fertilization practices.
Yao Zhou, Wen Li, Jing Ma, Jinzhen Li, Haixin Jiang, Guohui Wang, Yan Shen, Hongbin Ma   +7 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Potential Activities of Freshwater Exo- and Endo-Acting Extracellular Peptidases in East Tennessee and the Pocono Mountains

Frontiers in Microbiology, 2018
Proteins constitute a particularly bioavailable subset of organic carbon and nitrogen in aquatic environments but must be hydrolyzed by extracellular enzymes prior to being metabolized by microorganisms.
Lauren Mullen, Malcolm X Shabazz High School Aquatic Biogeochemistry Team, Kim Boerrigter, Kim Boerrigter, Nicholas Ferriero, Jeff Rosalsky, Abigail van Buren Barrett, Patrick J. Murray, Andrew D. Steen   +8 more
doaj   +1 more source