Results 41 to 50 of about 13,225 (225)
Analyzing the Binding of Co(II)-specific Inhibitors to the Methionyl Aminopeptidases from \u3cem\u3eEscherichia coli\u3c/em\u3e and \u3cem\u3ePyrococcus furiosus\u3c/em\u3e [PDF]
, 2009 Methionine aminopeptidases (MetAPs) represent a unique class of protease that is capable of the hydrolytic removal of an N-terminal methionine residue from nascent polypeptide chains.
Bennett, Brian +4 more
core +2 more sources
A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection
Advanced Science, EarlyView.A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez +13 more
wiley +1 more source
Scientific Reports, 2021 The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown.
Leonardo Capistrano Ferreira +6 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.SpyCatcher‐mi3 nanoparticles displaying RBD‐SD1 from MERS‐CoV, NL140422, and HKU4 elicited robust and cross‐reactive IgG responses in mice. Only MERS‐CoV RBD‐SD1 induced neutralizing antibodies against MERS‐CoV and protected human DPP4 mice from a MERS‐CoV challenge, indicating conserved serologic but limited cross‐neutralizing epitopes.
Peter J. Halfmann +9 more
wiley +1 more source
Limnology and Oceanography: Methods, EarlyView.Abstract Investigations of hydrostatic pressure effects on microbial enzymatic processing are challenging but critical for understanding element cycling in the world's oceans. In this study, we developed and tested a stainless‐steel pressure cell capable of withstanding up to 110 MPa of hydrostatic pressure (equivalent to ~ 11,000 m depth), featuring ...
Maria Papadimitraki +6 more
wiley +1 more source
Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov +3 more
wiley +1 more source
Journal of Pure and Applied MicrobiologyThe manipulation of keratinolytic determinants provides an avenue for enhancing keratinase output, thereby facilitating the conversion of wasted chicken feathers into valuable products.
Lindelwa Mpaka +2 more
doaj +1 more source
Heterologous Expression and Purification of \u3cem\u3eVibrio proteolyticus (Aeromonas proteolytica)\u3c/em\u3e Aminopeptidase: A Rapid Protocol [PDF]
, 2009 Metalloaminopeptidases (mAPs) are enzymes that are involved in HIV infectivity, tumor growth and metastasis, angiogenesis, and bacterial infection. Investigation of structure–function relationships in mAPs is a prerequisite to rational design of anti-mAP
Bennett, Brian, Hartley, Mariam
core +1 more source
The activity of a Hexameric M17 Metallo-Aminopeptidase is associated with survival of Mycobacterium tuberculosis [PDF]
, 2017 Mycobacterium tuberculosis is one of the most prevalent human pathogens causing millions of deaths in the last years. Moreover, tuberculosis (TB) treatment has become increasingly challenging owing to the emergence of multidrug resistant M.
Bastos, Izabela Marques Dourado +5 more
core +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source