Results 11 to 20 of about 9,790 (260)

An efficient RuCl3·H2O/I2 catalytic system: A facile access to 3-aroylimidazo[1,2-a]pyridines from 2-aminopyridines and chalcones

Journal of Saudi Chemical Society, 2018
A simple and efficient protocol has been demonstrated for the preparation of densely functionalized 3-aroylimidazo[1,2-a]pyridines from 2-aminopyridines and chalcones using RuCl3·H2O/I2 catalytic system.
P.V. Sri Ramya, Srinivas Angapelly, Chander Singh Digwal, Upasana Yadav, Bathini Nagendra Babu, Ahmed Kamal   +5 more
doaj   +1 more source

Neuroprotective Properties of 4-Aminopyridine [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2021
As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used as symptomatic therapy in several neurologic disorders. The improvement of visual function and motor skills and relieve of fatigue in patients with MS have been attributed to 4-AP.
Dietrich, Michael, Hartung, Hans-Peter, Albrecht, Philipp   +2 more
openaire   +2 more sources

Entry point into new trimeric and tetrameric imide-based macrocyclic esters derived from isophthaloyl dichloride and methyl 6-aminonicotinate [PDF]

, 2012
The one-step reaction of isophthaloyl dichloride with the 2-aminopyridine derivative (methyl 6-aminonicotinate) yields (i) a trimer-based macrocycle (EsIO)3 and (ii) a tetramer-based macrocycle (EsIO)4 in modest isolated synthetic yields (total of 25 ...
Gallagher, John F., Mocilac, Pavle
core   +2 more sources

An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

Beilstein Journal of Organic Chemistry, 2023
An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary
Shubham Sharma, Dharmender Singh, Sunit Kumar, Vaishali, Rahul Jamra, Naveen Banyal, Deepika, Chandi C. Malakar, Virender Singh   +8 more
doaj   +1 more source

Synthesis of 3-aminoimidazo[1,2-a]pyridines via three-component reaction in the 2,2,2-trifluoroethanol-water two-phase systems [PDF]

شیمی کاربردی روز, 2020
An efficient synthesis of 3-aminoimidazo[1,2-a]pyridines via three-component reaction from aromatic aldehydes, 2-aminopyridines and isonitriles at room temperature in water/2,2,2-trifluoroethanol two-phase systems is described.
Mobina Alizade-Majd, Afshin Sarvary, Masoud Nahali   +2 more
doaj   +1 more source

Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro [PDF]

, 1980
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
A Nistri, A Tokunaga, B Hue, B Katz, C Nicholson, CL Schauf, DA Brown, DA Brown, DA Brown, DA Brown, DA McAfee, DI Wallis, E Jankowska, E Kato, E Kato, G. ten Bruggencate, H Lundh, H Lundh, H Meves, IG Marshall, JE Heuser, JZ Yeh, JZ Yeh, K Golenhofen, M Lemeignan, M Lemeignan, M. Galvan, NG Bowery, P. Grafe, PR Adams, R Llinás, SY Chiu, T Brismar, T Yanagisawa, W Ulbricht, WC Bowman, WW Douglas   +36 more
core   +1 more source

Application of recyclable base-washed graphene oxide for one-pot conversion of 2-aminopyridines into 5-iodo-imidazo[1,2-a]pyridines at room temperature in water

Results in Chemistry, 2022
A green synthetic protocol for cyclization of 2-aminopyridines with 2-bromoacetophenones to prepare imidazo[1,2-a]pyridines, followed by its successive iodination in one-pot manner, employing base-washed graphene oxide as the catalyst, in water has been ...
Sumit Das, Bhagat Singh, Pulak Fadikar, Piyali Deb Barman, Rupankar Paira   +4 more
doaj   +1 more source

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Baranyi, Ben-Ari, Brismar, Brown, Buckle, Collins, Constanti, DiFrancesco, Dingemanse, Galvan, Galvan, Galvan, Gerrit Ten Bruggencate, Gilbey, Golenhofen, Halliwell, Heinemann, Jankowska, Jefferys, Kocsis, Lemeignan, Lipicky, Llinaś, Lundh, Martin Galvan, Matthews, McAfee, Mori, Neuman, Nicholson, Nicoll, Pelhate, Peter Grafe, Pichon, Scholfield, Scholfield, Schwartzkroin, Schwartzkroin, Sherratt, Shimahara, Spyker, Szente, Thesleff, Thompson, Ulbricht, von Haxthausen, Yanagisawa, Yeh   +47 more
core   +1 more source

Synthesis and Regularities of the Structure–Activity Relationship in a Series of N-Pyridyl-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides

Scientia Pharmaceutica, 2019
According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-dioxo-1H-2&
Igor V. Ukrainets, Anna A. Burian, Ganna M. Hamza, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Kateryna O. Burian, Galina Sim   +8 more
doaj   +1 more source

Rapid protium-deuterium exchange of 4-aminopyridines in neutral D2O under microwave irradiation [PDF]

, 2016
4-Aminopyridines undergo surprisingly rapid and highly-selective H/D exchange at C-2 and C-6 in neutral D2O upon microwave irradiation at only 190 °C for 2 h in a sealed vessel.
Alnomsy, Ayed, Bagley, Mark C, Sharhan, Hussein I   +2 more
core   +1 more source