Results 11 to 20 of about 3,296 (168)

Neuroprotective Properties of 4-Aminopyridine [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2021
As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used as symptomatic therapy in several neurologic disorders. The improvement of visual function and motor skills and relieve of fatigue in patients with MS have been attributed to 4-AP.
Dietrich, Michael, Hartung, Hans-Peter, Albrecht, Philipp   +2 more
openaire   +2 more sources

Synthesis of 3-aminoimidazo[1,2-a]pyridines via three-component reaction in the 2,2,2-trifluoroethanol-water two-phase systems [PDF]

شیمی کاربردی روز, 2020
An efficient synthesis of 3-aminoimidazo[1,2-a]pyridines via three-component reaction from aromatic aldehydes, 2-aminopyridines and isonitriles at room temperature in water/2,2,2-trifluoroethanol two-phase systems is described.
Mobina Alizade-Majd, Afshin Sarvary, Masoud Nahali   +2 more
doaj   +1 more source

An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

Beilstein Journal of Organic Chemistry, 2023
An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary
Shubham Sharma, Dharmender Singh, Sunit Kumar, Vaishali, Rahul Jamra, Naveen Banyal, Deepika, Chandi C. Malakar, Virender Singh   +8 more
doaj   +1 more source

Application of recyclable base-washed graphene oxide for one-pot conversion of 2-aminopyridines into 5-iodo-imidazo[1,2-a]pyridines at room temperature in water

Results in Chemistry, 2022
A green synthetic protocol for cyclization of 2-aminopyridines with 2-bromoacetophenones to prepare imidazo[1,2-a]pyridines, followed by its successive iodination in one-pot manner, employing base-washed graphene oxide as the catalyst, in water has been ...
Sumit Das, Bhagat Singh, Pulak Fadikar, Piyali Deb Barman, Rupankar Paira   +4 more
doaj   +1 more source

Synthesis and Regularities of the Structure–Activity Relationship in a Series of N-Pyridyl-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides

Scientia Pharmaceutica, 2019
According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-dioxo-1H-2&
Igor V. Ukrainets, Anna A. Burian, Ganna M. Hamza, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Kateryna O. Burian, Galina Sim   +8 more
doaj   +1 more source

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

Molecules, 2003
3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga, Yasuo Tohda, Kazushige Hori, Mina Tamura, Nagatoshi Nishiwaki   +4 more
doaj   +1 more source

Synthesis of imidazo[1,2-a]pyridine derivatives and Zolimidine via a novel zinc/iodine-catalyzed Ortoleva-King type protocol

Results in Chemistry, 2023
Imidazo[1,2-a]pyridines belong to a class of heterocyclic motifs possessing unique structural and pharmacological properties making them an interesting and promising domain in the fields of drug discovery and medicinal chemistry.
Mohan Neetha, Elsa Biya, Gopinathan Anilkumar   +2 more
doaj   +1 more source

Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines

Molecules, 2011
The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3-dithiazol-ium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-X-amines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized with respect to base ...
Panayiotis A. Koutentis, Maria Koyioni, Sophia S. Michaelidou   +2 more
doaj   +1 more source

Synthesis of Pyridin-1(2H)-ylacrylates and the Effects of Different Functional Groups on Their Fluorescence

Molecules, 2023
While fluorescent organic materials have many potential as well as proven applications and so have attracted significant attention, pyridine–olefin conjugates remain a less studied subset of such systems.
Weiguang Yang, Danyang Luo, Guanrong Li, Qiaoli Luo, Martin G. Banwell, Lanmei Chen   +5 more
doaj   +1 more source

Improvement of diaphragm and limb muscle isotonic contractile performance by K⁺ channel blockade

Journal of NeuroEngineering and Rehabilitation, 2010
The K+ channel blocking aminopyridines greatly improve skeletal muscle isometric contractile performance during low to intermediate stimulation frequencies, making them potentially useful as inotropic agents for functional neuromuscular stimulation ...
Pollarine Jennifer, van Lunteren Erik
doaj   +1 more source