Presynaptic facilitation at the crayfish neuromuscular junction: Role of calcium-activated potassium conductance [PDF]
, 1991 Membrane potential was recorded intracellularly near presynaptic terminals of the excitor axon of the crayfish opener neuromuscular junction (NMJ), while transmitter release was recorded postsynaptically.
Bittner, George D. +2 more
core +1 more source
Halogenation of pyridinium-N-(2'-pyridyl)aminide: an easy synthesis of halo-2-aminopyridines [PDF]
, 1995 The regioselective halogenatmn of pyrldmium-N-(2’-pyridyljaminide 1 with N-chloro,\ud bromo or iodosuccinimtde under mild conditions IS described. The method, combined with a\ud reductmn of the N-N bond, allows an easy preparation of 5-h& and 3,5-dihalo ...
Burgos García, Carolina +4 more
core +2 more sources
Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen. [PDF]
, 2016 Pyrido[1,2-a]pyrimidin-2-ones represent a pharmaceutically interesting class of heterocycles. The structurally related pyrido[1,2-a]pyrimidin-4-ones are associated with a broad range of useful biological properties.
Alanine, TA +5 more
core +1 more source
The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
Molecules, 2003 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga +4 more
doaj +1 more source
Results in Chemistry, 2023 Imidazo[1,2-a]pyridines belong to a class of heterocyclic motifs possessing unique structural and pharmacological properties making them an interesting and promising domain in the fields of drug discovery and medicinal chemistry.
Mohan Neetha +2 more
doaj +1 more source
Palladium-catalysed amination of electron-deficient or relatively-rich benzo[b]thienylbromides: preliminary studies of antimicrobial activity and SARs [PDF]
, 2004 Several diarylamines in the benzo[b]thiophene series were prepared by palladium catalyzed amination of ethyl 3-bromobenzo[b]thien-2-yl carboxylate with anilines and 5-aminoindole, in good to high yields using Pd(OAc)2, BINAP, Cs2CO3 in toluene.
Barbosa, Sandra +6 more
core +2 more sources
Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines
Molecules, 2011 The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3-dithiazol-ium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-X-amines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized with respect to base ...
Panayiotis A. Koutentis +2 more
doaj +1 more source
Microwave-assisted Bohlmann–Rahtz synthesis of highly-substituted 2-aminonicotinates [PDF]
, 2016 Microwave irradiation of 2-carbethoxyacetamidine and an ethynyl ketone under acidic or basic conditions in ethanol at 150 °C for 1.5 h facilitated Bohlmann-Rahtz pyridine synthesis to give highly-substituted ethyl 2 aminonicotinates with total ...
Alnomsy, Ayed +2 more
core +1 more source
A New Class of Small Molecule Inhibitor of BMP Signaling [PDF]
, 2013 Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor kinase ALK2 (ACVR1) are needed ...
Bullock, AN +11 more
core +13 more sources
Molecules, 2023 While fluorescent organic materials have many potential as well as proven applications and so have attracted significant attention, pyridine–olefin conjugates remain a less studied subset of such systems.
Weiguang Yang +5 more
doaj +1 more source