Results 61 to 70 of about 3,296 (168)
Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve +11 more
wiley +1 more source
Characteristics of weak base-induced vacuoles formed around individual acidic organelles
Folia Histochemica et Cytobiologica, 2011 We have previously found that the weak base 4-aminopyridine induces Brownian motion of acidic organelles around which vacuoles are formed, causing organelle traffic disorder in neurons.
Tadashi Kawakami, Hiromi Hiruma
doaj +1 more source
Molecular imprinting for neurology: Materials, applications, and limitations
Ibrain, Volume 12, Issue 1, Page 3-37, Spring 2026.Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma +3 more
wiley +1 more source
Equine Veterinary Journal, Volume 58, Issue 2, Page 333-347, March 2026.Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik +2 more
wiley +1 more source
Exploring the use of dalfampridine (4‐aminopyridine) for treatment of ataxia in cerebellar stroke
PM&R, EarlyView.
Arjun Kotwal +4 more
wiley +1 more source
Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery
ChemMedChem, Volume 21, Issue 4, 25 February 2026.Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley +1 more source
Review: Current treatment of vestibular, ocular motor disorders and nystagmus
Therapeutic Advances in Neurological Disorders, 2009 Vertigo and dizziness are among the most common complaints with a lifetime prevalence of about 30%. The various forms of vestibular disorders can be treated with pharmacological therapy, physical therapy, psychotherapeutic measures or, rarely, surgery ...
Michael Strupp, Thomas Brandt
doaj +1 more source
Inorganicsη6-Coordination catalysis has emerged as an effective strategy for activating electron-rich (hetero)arenes toward nucleophilic substitution. Recent experimental studies on Ru(II)-catalyzed amination of aminopyridines revealed a striking ortho–para ...
Cheng Wang, Shuo-Qing Zhang, Xin Hong
doaj +1 more source
Pharmacological management of nystagmus: An in-depth review for clinical practice
Oman Journal of OphthalmologyNystagmus, characterized by involuntary ocular movements, presents significant challenges in both congenital and acquired forms, often significantly impacting visual acuity and quality of life.
Hassan Asadigandomani +4 more
doaj +1 more source
HPW-Catalyzed environmentally benign approach to imidazo[1,2-a]pyridines
Beilstein Journal of Organic ChemistryThe imidazo[1,2-a]pyridine moiety is present in drugs with several biological activities. The most direct way of obtaining this nucleus is the Groebke–Blackburn–Bienaymé three-component reaction (GBB-3CR) between aminopyridines, aldehydes, and ...
Luan A. Martinho +1 more
doaj +1 more source