Results 11 to 20 of about 6,032 (181)

Excited-state relaxation of some aminoquinolines [PDF]

International Journal of Photoenergy, 2006
The absorption and fluorescence spectra, fluorescence quantum yields and lifetimes, and fluorescence rate constants ( k f ) of 2-amino-3-( 2 ′ -benzoxazolyl)quinoline (I), 2-amino-3-( 2 ′ ...
M. N. Khimich, B. M. Uzhinov
doaj   +3 more sources

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]

, 2002
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Docampo, Flohe, Moreno, Viode, Henderson, Walsh, Krauth-Seigel, Muller, Nogoceke, Tetaud, Wilkinson, Wilkinson, Tetaud, Wilkinson, Boveris, Fairlamb, Mehlotra, Carnieri, Kendall, Kelly, Gibson, Martinez-Calvillo, Kelly, Kelly, Kelly, Cannata, Rutter, Easterby, Gommel, Steinert, Sommer, Opperdoes, Opperdoes, Michels, Parsons, Blattner, Bjornstedt, Sztajer, Horiguchi, Holgren, Fabianek, Shih, Shih, van den Bosch, Subramani, Keller, Singh, Singh, Boveris, Duffieux, Goodman, Knoops, Yamashita, Verdoucq, Seo, Lopez, Krieger   +56 more
core   +4 more sources

QSAR and molecular docking studies of 1,3-dioxoisoindoline-4-aminoquinolines as potent antiplasmodium hybrid compounds

Heliyon, 2020
Quantitative structure–activity relationships (QSAR) provides a model that link biological activities of compounds to thier chemical stuctures and molecular docking study reveals the interaction between drug and its target enzyme.
Aliyu Wappah Mahmud, Gideon Adamu Shallangwa, Adamu Uzairu   +2 more
doaj   +1 more source

Anti‐malarial drug effects on parasite dynamics in vivax malaria

Malaria Journal, 2021
Relapses of Plasmodium vivax malaria are prevented by 8-aminoquinolines. If hypnozoites survive, then the subsequent blood stage infections in early relapses (
Nicholas J. White
doaj   +1 more source

Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores [PDF]

Journal of the Serbian Chemical Society, 2008
Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds.
IGOR M. OPSENICA, KIRSTEN K. SMITH, LUCIA GERENA, SANDRA GAICA, BOGDAN A. SOLAJA   +4 more
doaj   +3 more sources

Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities

Biomolecules, 2023
The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives.
Nicoletta Basilico, Silvia Parapini, Sarah D’Alessandro, Paola Misiano, Sergio Romeo, Giulio Dondio, Vanessa Yardley, Livia Vivas, Shereen Nasser, Laurent Rénia, Bruce M. Russell, Rossarin Suwanarusk, François Nosten, Anna Sparatore, Donatella Taramelli   +14 more
doaj   +1 more source

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization. [PDF]

PLoS ONE, 2018
Neovascularization is the pathological driver of blinding eye diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration.
Danielle McAnally, Khandaker Siddiquee, Ahmed Gomaa, Andras Szabo, Stefan Vasile, Patrick R Maloney, Daniela B Divlianska, Satyamaheshwar Peddibhotla, Camilo J Morfa, Paul Hershberger, Rebecca Falter, Robert Williamson, David B Terry, Rafal Farjo, Anthony B Pinkerton, Xiaping Qi, Judith Quigley, Michael E Boulton, Maria B Grant, Layton H Smith   +19 more
doaj   +1 more source

Catalyst controlled remote CH activation of 8-aminoquinolines with NFSI for CN versus CF coupling

Catalysis Communications, 2021
A catalyst-controlled selective functionalization of 8-aminoquinolines with N-fluorobenzenesulfonimide (NFSI) has been developed. The use of GTP-Cu catalysts leads to CN coupling products and whereas the CF coupling reaction is dominant for GPT-Ni ...
Kai Zheng, Enmu Zhou, Letian Zhang, Lixi Zhang, Wenbo Yu, Hao Xu, Chao Shen   +6 more
doaj   +1 more source

Aminoquinoline Derivatives as HCV Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2013
Aminoquinoline Derivatives as HCV Inhibitors Jean-Francois Brazeau and Gerard Rosse* Structure Guided Chemistry, Dart Neuroscience LLC, 7473 Lusk Boulevard, San Diego, California 92121, United States Adjunct Associate Professor, Department of Pharmacology and Physiology, College of Medicine, Drexel University, New College Building, 245 North 15th ...
Jean-Francois, Brazeau, Gerard, Rosse
openaire   +2 more sources

Aminoquinolines afford resistance to cerebral malaria in susceptible mice

Journal of Global Antimicrobial Resistance, 2020
Objectives: Malaria treatment is impeded by increasing resistance to conventional antimalarial drugs. Here we explored the activity of ten novel benzothiophene, thiophene and benzene aminoquinolines. Methods: In vitro testing was performed by the lactate
Jelena Srbljanović, Branko Bobić, Tijana Štajner, Aleksandra Uzelac, Igor Opsenica, Nataša Terzić-Jovanović, Neda Bauman, Bogdan A. Šolaja, Olgica Djurković-Djaković   +8 more
doaj   +1 more source