Results 31 to 40 of about 6,032 (181)

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones [PDF]

, 2008
A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P.
Jiri Gut, Margaret S Collins, Melanie T Cushionc, Nuno Vale, Paula Gomes, Philip J Rosenthal, Ricardo Ferraz, Rui Moreira   +7 more
core   +1 more source

Hybrids of 4-aminoquinolines and adamantane as inhibitors of AChE [PDF]

Journal of the Serbian Chemical Society
Alzheimer’s disease (AD) is an incurable and progressive neurodegenerative disorder that causes cognitive capabilities and memory loss and damage to brain functionality and structure.
Komatović Katarina, Matošević Ana, Zlatović Mario, Sladić Dušan, Bosak Anita, Opsenica Dejan M.   +5 more
doaj   +1 more source

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]

, 2013
Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
A Kronhardt, A Messmer, A Ménard, A Ménard, AA Verveen, AF Kintzer, AM Friedlander, Anika Bronnhuber, AW Artenstein, BA Krantz, C Andersen, C Bachmeyer, C Bachmeyer, C Petosa, Christoph Beitzinger, CT Bahner, D Blöcker, D Blöcker, DB Lacy, EM Nestorovich, EM Nestorovich, F Conti, F Orlik, F Orlik, F Tonello, F Tonello, F Wohnsland, G Hajós, G Timári, G Vitale, György Hajós, H Barth, H Barth, Holger Barth, I Zornetta, J Sun, J Wesche, JA Young, JC Milne, JL Elliott, K Cunningham, KA Bradley, Kerstin Duscha, L Abrami, L Abrami, L Abrami, L Abrami, L Song, Ludger Johannes, M Eigen, M Mock, Markus Huber-Lang, MJ Brown, NS Duesbery, PC Hanna, R Benz, R Benz, R Palkó, R Pellizzari, RJ Collier, RO Blaustein, RO Blaustein, Roland Benz, S Nekolla, SH Leppla, SM Bezrukov, SM Bezrukov, T Neumeyer, T Neumeyer, T Neumeyer, TC Dixon, V Escuyer, VA Karginov, VA Karginov, VA Karginov, Y Singh, Zsuzsanna Riedl   +76 more
core   +2 more sources

Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda. [PDF]

, 2016
: We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to ...
Asua, V, Conrad, M, Dorsey, G, Greenhouse, B, Kamya, MR, Nankabirwa, J, Nsobya, SL, Rosenthal, PJ, Ruhamyankaka, E, Staedke, SG, Taylor, A, Tukwasibwe, S, Tumwebaze, P, Walakira, A, Yeka, A   +14 more
core   +2 more sources

Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines

Frontiers in Immunology, 2020
The rapid spread, severity, and lack of specific treatment for COVID-19 resulted in hasty drug repurposing. Conceptually, trials of antivirals were well-accepted, but twentieth century antimalarials sparked an impassioned global debate.
Joana Vitte, Joana Vitte, Moïse Michel, Moïse Michel, Soraya Mezouar, Soraya Mezouar, Aïssatou Bailo Diallo, Aïssatou Bailo Diallo, Asma Boumaza, Asma Boumaza, Jean-Louis Mege, Jean-Louis Mege, Benoit Desnues, Benoit Desnues   +13 more
doaj   +1 more source

3-Acetyl-4-aminoquinoline

Acta Crystallographica Section E Structure Reports Online, 2007
The title compound, C11H10N2O, a potential antitumour drug, crystallizes with two molecules in the asymmetric unit. The 4-amino N atom is strongly conjugated with the quinoline ring involving the 3-carbonyl group. As a result, the molecule is almost planar.
Jan Lokaj, Viktor Kettmann, Petra Černuchová, Viktor Milata, Marek Fronc   +4 more
openaire   +1 more source

The Use of Antimalarial Drugs against Viral Infection

Microorganisms, 2020
In recent decades, drugs used to treat malaria infection have been shown to be beneficial for many other diseases, including viral infections. In particular, they have received special attention due to the lack of effective antiviral drugs against new ...
Sarah D’Alessandro, Diletta Scaccabarozzi, Lucia Signorini, Federica Perego, Denise P. Ilboudo, Pasquale Ferrante, Serena Delbue   +6 more
doaj   +1 more source

Genotype-phenotype association and biochemical analyses of glucose-6-phosphate dehydrogenase variants: Implications for the hemolytic risk of using 8-aminoquinolines for radical cure

Frontiers in Pharmacology, 2022
Background:Plasmodium vivax remains the malaria species posing a major threat to human health worldwide owing to its relapse mechanism. Currently, the only drugs of choice for radical cure are the 8-aminoquinolines (primaquine and tafenoquine), which are
Sirapapha Sudsumrit, Kamonwan Chamchoy, Duantida Songdej, Poom Adisakwattana, Srivicha Krudsood, Emily R. Adams, Mallika Imwong, Ubolsree Leartsakulpanich, Usa Boonyuen   +8 more
doaj   +1 more source

A first example of cobalt-catalyzed remote C-H functionalization of 8-aminoquinolines operating through a single electron transfer mechanism [PDF]

, 2016
The development of new C[BOND]H functionalization protocols based on inexpensive cobalt catalysts is currently attracting significant interest. Functionalized 8-aminoquinoline compounds are high-potential building blocks in organic chemistry and ...
Ackermann, Cong, Corbet, Donaldson, Dong, Fors, Galliker, Gandy, Goldstein, Grossi, Guo, Guo, He, Hong, Hu, Iwai, Katayev, Kilpatrick, Kochi, Koley, Liang, Liu, Liu, Maity, Moselage, Nakata, Olah, Ono, Planas, Qiao, Recht, Sahoo, Saito, Seuss, Taniguchi, Wang, Wei, Wei, Williams, Xia, Xu, Yan, Yan, Yoon, Zhang, Zhang, Zhang, Zhao, Zhou, Zhu   +49 more
core   +1 more source

Glucose-6-phosphate dehydrogenase activity measured by spectrophotometry and associated genetic variants from the Oromiya zone, Ethiopia

Malaria Journal, 2018
Background The study aimed to gain first data on the prevalence of G6PD enzyme deficiency measured by spectrophotometry and associated genetic variants in Jimma and surroundings, Ethiopia.
Nora Kießling, Joaquin Brintrup, Ahmed Zeynudin, Nuredin Abduselam, Sylvia Götz, Margith Mack, Michael Pritsch, Andreas Wieser, Elisabeth Kohne, Nicole Berens-Riha   +9 more
doaj   +1 more source