Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents. [PDF]
, 2017 BACKGROUND: The simian malaria parasite Plasmodium knowlesi is now a well-recognized pathogen of humans in South-East Asia. Clinical infections appear adequately treated with existing drug regimens, but the evidence base for this practice remains weak ...
Blasco, Benjamin +3 more
core +1 more source
Pharmacological considerations in the design of anti-malarial drug combination therapies - is matching half-lives enough? [PDF]
, 2014 Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary ...
Hodel, Eva Maria
core +1 more source
European Journal of Medicinal Chemistry Reports, 2022 Malaria parasites continue to pose a concern. Drug resistance underlines the need for new structural cores that, when combined with existing antimalarial frameworks, can partially re-sensitize drug-resistant parasites to available antimalarial drugs ...
Bharvi Sharma +6 more
doaj +1 more source
Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines [PDF]
Antimalarials can interact with heme covalently, by - interactions or hydrogen bonding. Consequently, the prototropy of 4-aminoquinolines and quinoline methanols was investigated using quantum mechanics.
Alizadeh, S +14 more
core +1 more source
Review of pyronaridine anti-malarial properties and product characteristics. [PDF]
, 2012 Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J +7 more
core +2 more sources
THE ACTIVITY OF 4-AMINOQUINOLINE AGAINST PLASMODIUM FALCIPARUM IN SOUTHERN IRAN
Iranian Journal of Public Health, 1973 The resistance of Plasmodium falciparum to 4-amioquinolines has been confirmed in parts of South America such as Venezuela, Colombia, Brazil and Panama since 1961. During 1968-1970, 147 P.
AV. Manouchehri +2 more
doaj
Memorias do Instituto Oswaldo Cruz, 1992 With the use of a simple formulary, field by health agents was ewstablished a monitoring programme for responses of P. falciparum to the antimalarial drugs.
José Maria de Souza
doaj +1 more source
Molecular Markers of In Vivo Plasmodium vivax Resistance to Amodiaquine Plus Sulfadoxine-Pyrimethamine: Mutations in pvdhfr and pvmdr1 [PDF]
, 2017 Background. Molecular markers for sulfadoxine-pyrimethamine (SP) resistance in Plasmodium vivax have been reported. However, data on the molecular correlates involved in the development of resistance to 4-aminoquinolines and their association with the in
Barbollat, Laetitia +10 more
core
Peptidomimetic and Organometallic Derivatives of Primaquine Active against Leishmania infantum [PDF]
, 2012 The current treatment of visceral leishmaniasis is made difficult by the low efficacy, elevated costs, low bioavailability, and high toxicity of many of the available drugs.
Ana Tomas +6 more
core +1 more source
Antiproliferative evaluation of various aminoquinoline derivatives
Acta Pharmaceutica, 2019 Abstract Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were ...
ZORC, BRANKA +2 more
openaire +4 more sources