Results 241 to 250 of about 2,340,313 (291)

Characterization of amorphous solid dispersions

Journal of Pharmaceutical Investigation, 2017
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the bioavailability of poorly water-soluble drugs over conventional delivery systems.
Xu Liu, Xin Feng, Robert O. Williams, Feng Zhang   +3 more
openaire   +1 more source

Multifractal and mechanical analysis of amorphous solid dispersions

International Journal of Pharmaceutics, 2017
The formulation of lipophilic and hydrophobic compounds is a challenge for the pharmaceutical industry and it requires the development of complex formulations. Our first aim was to investigate hot-melt extrudate microstructures by means of multifractal analysis using scanning electron microscopy imaging. Since the microstructure can affect solid dosage
Adler C, Teleki A, Kuentz M
openaire   +4 more sources

Stability of Amorphous Solid Dispersion

2014
Amorphous solid dispersion (ASD) has attracted tremendous attention in pharmaceutical development due to its characteristic solubility enhancement, thus positively affecting oral bioavailability of a range of hydrophobic drugs. Nevertheless, being in a metastable state, ASD has the intrinsic tendency of spontaneously reverting to a more stable ...
Xiang Kou, Liping Zhou
openaire   +1 more source

Dissolution and Precipitation Behavior of Amorphous Solid Dispersions

Journal of Pharmaceutical Sciences, 2011
Amorphous solid dispersions (ASDs) are widely utilized in the pharmaceutical industry for bioavailability enhancement of low solubility drugs. The important factors governing the dissolution behavior of these systems are still far from adequately understood.
David E, Alonzo, Yi, Gao, Deliang, Zhou, Huaping, Mo, Geoff G Z, Zhang, Lynne S, Taylor   +5 more
openaire   +2 more sources

Excipients for Amorphous Solid Dispersions

2014
Pharmaceutical excipients play a significant role in stabilization of amorphous solid dispersions, as these systems are thermodynamically unstable. This chapter illustrates the challenges associated with amorphous solid dispersion stability and the role that excipients play in stabilization of amorphous solid dispersions by influencing the ...
Siva Ram Kiran Vaka, Murali Mohan Bommana, Dipen Desai, Jelena Djordjevic, Wantanee Phuapradit, Navnit Shah   +5 more
openaire   +1 more source

Diffusivity of amorphous drug in solid dispersion

Journal of Thermal Analysis and Calorimetry, 2013
Filmy solid dispersion of terfenadine (TFD), fenofibrate (FFB), and carbamazepine (CBZ) and methacrylic acid methyl methacrylate copolymer (Eudragit®) was prepared by evaporating their solution. Raman and IR measurements for the filmy samples were performed.
Etsuo Yonemochi, Shohei Sano, Yasuo Yoshihashi, Katsuhide Terada   +3 more
openaire   +1 more source

Dissolution Mechanisms of Amorphous Solid Dispersions

2023
The dissolved concentration of an active pharmaceutical ingredient in biological fluids is of significant importance for establishing a therapeutic effect in patients. However, the current pharmaceutical landscape is abundant in poorly soluble drugs that require solubility enhancing techniques to enable their administration. A promising technique, with
openaire   +1 more source

Structural Characterization of Amorphous Solid Dispersions

2014
Amorphous solid dispersions (ASD) stand on the forefront of solubilizing formulations for many poorly soluble drug candidates. It has been widely accepted that the physical stability, downstream processability, and performance of an ASD largely inherits its physical structure. The in-depth and multi-methodological characterization of ASD microstructure
Amrit Paudel, Joke Meeus, Guy Van den Mooter   +2 more
openaire   +1 more source

Release Mechanisms of Amorphous Solid Dispersions

2022
   As the pharmaceutical industry moves towards molecular obesity with the use of high throughput screening for identification of promising candidates, the low aqueous solubilities of new chemical entities pose significant challenges to achieving adequate oral absorption and bioavailability. Enabling formulations are often needed to address this issue.
openaire   +1 more source

Overview of Amorphous Solid Dispersion Technologies

2014
Successful development of amorphous solid dispersion formulations depends on three primary factors: active pharmaceutical ingredient properties, stabilizing polymer, and the processing technology. Polymer provides the fundamental framework for stabilizing the amorphous form and the process supplies the energy required to transform the system into an ...
Harpreet Sandhu, Navnit Shah, Hitesh Chokshi, A.Waseem Malick   +3 more
openaire   +1 more source