Results 241 to 250 of about 118,785 (293)
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Sustained-release amorphous solid dispersions
Drug Delivery and Translational Research, 2018The use of amorphous solid dispersions (ASD) to overcome poor drug solubility has gained interest in the pharmaceutical industry over the past decade. ASDs are challenging to formulate because they are thermodynamically unstable, and the dispersed drugs tend to recrystallize.
Julien, Maincent, Robert O, Williams
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Dissolution testing of amorphous solid dispersions
International Journal of Pharmaceutics, 2013The main purpose of this study was to investigate the effect of different polymers, with varying physicochemical properties and molecular weight on the stability and dissolution of co-milled amorphous solid dispersions (ASDs) of piroxicam (PRX). The stability of amorphous PRX (aPRX) in ASDs was significantly improved by the polymers.
K, Kogermann +6 more
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Molecular-Level Examination of Amorphous Solid Dispersion Dissolution
Molecular Pharmaceutics, 2021Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form which are dispersed in a hydrophilic polymer matrix. Producing a high-performance ASD is critical for effective drug delivery and depends on many factors such as solubility of ...
Mohammad Atif Faiz Afzal +11 more
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Characterization of amorphous solid dispersions
Journal of Pharmaceutical Investigation, 2017The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the bioavailability of poorly water-soluble drugs over conventional delivery systems.
Xu Liu +3 more
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Assessing the performance of amorphous solid dispersions
Journal of Pharmaceutical Sciences, 2012The characterization and performance of stable amorphous solid dispersion systems were evaluated in 40 research papers reporting active pharmaceutical ingredient (API) dissolution and bioavailability from various systems containing polymers. The results from these studies were broadly placed into three categories: amorphous dispersions that improved ...
Ann, Newman +2 more
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Forced Solid-State Oxidation Studies of Nifedipine-PVP Amorphous Solid Dispersion
Molecular Pharmaceutics, 2022In the present study, the oxidative degradation behavior of nifedipine (NIF) in amorphous solid dispersions (ASDs) prepared with poly(vinyl pyrrolidone) (PVP) with a short (K30) and a long (K90) chain length was investigated. The ASDs were prepared via dry ball-milling and analyzed using Fourier transform infrared (IR) spectroscopy, X-ray scattering ...
Isha Saraf +7 more
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Solubility advantage from amorphous etoricoxib solid dispersions
Drug Development and Industrial Pharmacy, 2013This study aimed to evaluate kinetic solubility advantage of amorphous etoricoxib solid dispersions prepared with three water soluble polymers and correlate it with solid state and supersaturated drug solution stabilization potential of these polymers.Amorphous solid dispersions (ASDs) of etoricoxib were prepared with polyvinyl alcohol (PVA), polyvinyl
Prateek, Dani, Vibha, Puri, A K, Bansal
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KinetiSol®-Based Amorphous Solid Dispersions
2014KinetiSol is a novel fusion-based process for the production of amorphous solid dispersion systems that has been adapted for pharmaceutical processing from the plastics recycling industry. With its unique process attributes, KinetiSol is providing novel solutions for difficult-to-process poorly water-soluble compounds.
Dave A. Miller, Justin M. Keen
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Excipients for Amorphous Solid Dispersions
2014Pharmaceutical excipients play a significant role in stabilization of amorphous solid dispersions, as these systems are thermodynamically unstable. This chapter illustrates the challenges associated with amorphous solid dispersion stability and the role that excipients play in stabilization of amorphous solid dispersions by influencing the ...
Siva Ram Kiran Vaka +5 more
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Stability of Amorphous Solid Dispersion
2014Amorphous solid dispersion (ASD) has attracted tremendous attention in pharmaceutical development due to its characteristic solubility enhancement, thus positively affecting oral bioavailability of a range of hydrophobic drugs. Nevertheless, being in a metastable state, ASD has the intrinsic tendency of spontaneously reverting to a more stable ...
Xiang Kou, Liping Zhou
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