Results 241 to 250 of about 30,050 (289)

Xenes for Sustainable Energy: A Roadmap From First‐Principles Design to Practical Deployment

Advanced Materials Interfaces, EarlyView.
Emerging 2D Xenes are advancing from theoretical predictions toward practical energy‐storage and conversion technologies through the integration of first‐principles modelling, experimental synthesis, electrochemical validation, and AI‐assisted materials design, enabling accelerated discovery of high‐performance and sustainable electrochemical systems ...
Onur Karaman, Ceren Karaman
wiley   +1 more source

On the Friction and Wear Mechanisms of Electrified Steel Contacts in CO2: Unveiling the Role of Carbon‐Rich Tribofilms Under Dry Sliding Conditions

Advanced Materials Interfaces, EarlyView.
This study investigates friction and wear of AISI 52100 steel under dry sliding in CO2, air, and N2 atmospheres, with and without contact electrification. CO2 forms a stable carbon‐rich tribofilm that reduces friction by ∼30% and wear by ∼85%. High‐resolution TEM, EELS, and molecular dynamics reveal pressure‐dependent lubrication mechanisms, showing ...
Julio A. Cao‐Romero‐Gallegos, Seungjoo Lee, Cagatay Yelkarasi, Leonardo I. Farfan‐Cabrera, Ryuichi Okamoto, Hitoshi Washizu, Ali Erdemir   +6 more
wiley   +1 more source

The Stabilization of Amorphous Zopiclone in an Amorphous Solid Dispersion [PDF]

AAPS PharmSciTech, 2015
Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion. The amorphous form was prepared by the well-known method of quench-cooling of the melt. The solid dispersion was prepared by a
Wilna Liebenberg, Marique Aucamp
exaly   +6 more sources

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Sustained-release amorphous solid dispersions

Drug Delivery and Translational Research, 2018
The use of amorphous solid dispersions (ASD) to overcome poor drug solubility has gained interest in the pharmaceutical industry over the past decade. ASDs are challenging to formulate because they are thermodynamically unstable, and the dispersed drugs tend to recrystallize.
Julien, Maincent, Robert O, Williams
openaire   +2 more sources

Assessing the performance of amorphous solid dispersions

Journal of Pharmaceutical Sciences, 2012
The characterization and performance of stable amorphous solid dispersion systems were evaluated in 40 research papers reporting active pharmaceutical ingredient (API) dissolution and bioavailability from various systems containing polymers. The results from these studies were broadly placed into three categories: amorphous dispersions that improved ...
Ann, Newman, Gregory, Knipp, George, Zografi   +2 more
openaire   +2 more sources

Dissolution testing of amorphous solid dispersions

International Journal of Pharmaceutics, 2013
The main purpose of this study was to investigate the effect of different polymers, with varying physicochemical properties and molecular weight on the stability and dissolution of co-milled amorphous solid dispersions (ASDs) of piroxicam (PRX). The stability of amorphous PRX (aPRX) in ASDs was significantly improved by the polymers.
K, Kogermann, A, Penkina, K, Predbannikova, K, Jeeger, P, Veski, J, Rantanen, K, Naelapää   +6 more
openaire   +2 more sources

Characterization of amorphous solid dispersions

Journal of Pharmaceutical Investigation, 2017
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the bioavailability of poorly water-soluble drugs over conventional delivery systems.
Xu Liu, Xin Feng, Robert O. Williams, Feng Zhang   +3 more
openaire   +1 more source

Multifractal and mechanical analysis of amorphous solid dispersions

International Journal of Pharmaceutics, 2017
The formulation of lipophilic and hydrophobic compounds is a challenge for the pharmaceutical industry and it requires the development of complex formulations. Our first aim was to investigate hot-melt extrudate microstructures by means of multifractal analysis using scanning electron microscopy imaging. Since the microstructure can affect solid dosage
Adler C, Teleki A, Kuentz M
openaire   +4 more sources

Downstream processing of amorphous solid dispersions into orodispersible tablets

International Journal of Pharmaceutics, 2023
The formulation development of amorphous solid dispersions (ASDs) towards a patient-friendly oral solid dosage form is proving to be still challenging. To increase patient's compliance orodispersible tablets (ODTs) can be seen as promising alternative.
Marcel, Kokott, Stefan, Klinken, Jörg, Breitkreutz, Raphael, Wiedey   +3 more
openaire   +2 more sources

Dissolution and Precipitation Behavior of Amorphous Solid Dispersions

Journal of Pharmaceutical Sciences, 2011
Amorphous solid dispersions (ASDs) are widely utilized in the pharmaceutical industry for bioavailability enhancement of low solubility drugs. The important factors governing the dissolution behavior of these systems are still far from adequately understood.
David E, Alonzo, Yi, Gao, Deliang, Zhou, Huaping, Mo, Geoff G Z, Zhang, Lynne S, Taylor   +5 more
openaire   +2 more sources