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Physical Stability Studies of Miscible Amorphous Solid Dispersions
Journal of Pharmaceutical Sciences, 2010Physical stability of 12 amorphous solid dispersions was evaluated over 9-22 months under ambient conditions using X-ray powder diffraction. The nine dispersions initially characterized as miscible drug-polymer systems all remained X-ray amorphous for the duration of their respective studies.
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Theoretical Considerations in Developing Amorphous Solid Dispersions
2014Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is the topic of many of the subsequent chapters in this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route is a viable one for a given drug and how much solubility improvement, and hence increase in ...
Laitinen, Riikka +6 more
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Orodispersible films based on amorphous solid dispersions of tetrabenazine
International Journal of Pharmaceutics, 2017In this work, the formation and stability of amorphous solid dispersions (SDs) as orodispersible films (ODF) were investigated using tetrabenazine (TBZ) as a poorly water soluble drug. The influence of polymer nature and pH-modifier incorporation to form and maintain SDs was investigated. TBZ-loaded ODF were formulated using 4 different polymers (HPMC,
Senta-Loys, Zoé +4 more
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Amorphous Solid Dispersion Using Supercritical Fluid Technology
2014Use of supercritical fluid (SCF) processing technologies in the pharmaceutical industry has seen remarkable growth as an alternate technology for the preparation of micro- and nano-sized particles. Carbon dioxide, having low critical temperature (31.2 °C) and pressure (73.8 bar or 7.4 Mpa) and being nonflammable, nontoxic, and environmentally safe, is ...
Pratik Sheth, Harpreet Sandhu
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Ternary Amorphous Solid Dispersions
Journal of Developing Drugs, 2017Dev Prasad +3 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
exaly
Bio-enabling Technologies for Amorphous Solid Dispersions
2023A tecnologia farmacêutica está em constante desenvolvimento, com o objetivo de enfrentar os desafios que surgem na administração de medicamentos e na eficácia terapêutica. A proporção de substâncias ativas com baixa solubilidade aquosa tem aumentado ao longo dos anos e domina o portfólio das etapas iniciais do desenvolvimento de medicamentos ...
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Drug release mechanisms from amorphous solid dispersions
Journal of Controlled Release, 2015openaire +2 more sources