Results 251 to 260 of about 118,785 (293)

Dissolution and Precipitation Behavior of Amorphous Solid Dispersions

Journal of Pharmaceutical Sciences, 2011
Amorphous solid dispersions (ASDs) are widely utilized in the pharmaceutical industry for bioavailability enhancement of low solubility drugs. The important factors governing the dissolution behavior of these systems are still far from adequately understood.
David E, Alonzo, Yi, Gao, Deliang, Zhou, Huaping, Mo, Geoff G Z, Zhang, Lynne S, Taylor   +5 more
openaire   +2 more sources

Structural Characterization of Amorphous Solid Dispersions

2014
Amorphous solid dispersions (ASD) stand on the forefront of solubilizing formulations for many poorly soluble drug candidates. It has been widely accepted that the physical stability, downstream processability, and performance of an ASD largely inherits its physical structure. The in-depth and multi-methodological characterization of ASD microstructure
Amrit Paudel, Joke Meeus, Guy Van den Mooter   +2 more
openaire   +1 more source

Multifractal and mechanical analysis of amorphous solid dispersions

International Journal of Pharmaceutics, 2017
The formulation of lipophilic and hydrophobic compounds is a challenge for the pharmaceutical industry and it requires the development of complex formulations. Our first aim was to investigate hot-melt extrudate microstructures by means of multifractal analysis using scanning electron microscopy imaging. Since the microstructure can affect solid dosage
Adler C, Teleki A, Kuentz M
openaire   +3 more sources

Dissolution Mechanisms of Amorphous Solid Dispersions

2023
The dissolved concentration of an active pharmaceutical ingredient in biological fluids is of significant importance for establishing a therapeutic effect in patients. However, the current pharmaceutical landscape is abundant in poorly soluble drugs that require solubility enhancing techniques to enable their administration. A promising technique, with
openaire   +1 more source

Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions

Current Pharmaceutical Design, 2014
Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and ...
Chow, Albert H.L., Lee, Thomas W.Y., Boersen, Nathan A., Hui, H. W., Chow, S. F., Wan, K. Y.   +5 more
openaire   +4 more sources

Release Mechanisms of Amorphous Solid Dispersions

2022
As the pharmaceutical industry moves towards molecular obesity with the use of high throughput screening for identification of promising candidates, the low aqueous solubilities of new chemical entities pose significant challenges to achieving adequate oral absorption and bioavailability.
openaire   +1 more source

Overview of Amorphous Solid Dispersion Technologies

2014
Successful development of amorphous solid dispersion formulations depends on three primary factors: active pharmaceutical ingredient properties, stabilizing polymer, and the processing technology. Polymer provides the fundamental framework for stabilizing the amorphous form and the process supplies the energy required to transform the system into an ...
Harpreet Sandhu, Navnit Shah, Hitesh Chokshi, A.Waseem Malick   +3 more
openaire   +1 more source

Diffusivity of amorphous drug in solid dispersion

Journal of Thermal Analysis and Calorimetry, 2013
Filmy solid dispersion of terfenadine (TFD), fenofibrate (FFB), and carbamazepine (CBZ) and methacrylic acid methyl methacrylate copolymer (Eudragit®) was prepared by evaporating their solution. Raman and IR measurements for the filmy samples were performed.
Etsuo Yonemochi, Shohei Sano, Yasuo Yoshihashi, Katsuhide Terada   +3 more
openaire   +1 more source

Anomalous transit-time dispersion in amorphous solids

Physical Review B, 1975
Measurements of the transient photocurrent $I(t)$ in an increasing number of inorganic and organic amorphous materials display anomalous transport properties. The long tail of $I(t)$ indicates a dispersion of carrier transit times. However, the shape invariance of $I(t)$ to electric field and sample thickness (designated as universality for the classes
Harvey Scher, Elliott W. Montroll
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Characterization of amorphous solid dispersions: An update

Journal of Drug Delivery Science and Technology, 2019
Abstract Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have complicated physicochemical properties due to the various formulations and processes used to produce them. These properties influence their physical stability, so it
Xiangyu Ma, Robert O. Williams
openaire   +1 more source