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Solubility advantage from amorphous etoricoxib solid dispersions
Drug Development and Industrial Pharmacy, 2013This study aimed to evaluate kinetic solubility advantage of amorphous etoricoxib solid dispersions prepared with three water soluble polymers and correlate it with solid state and supersaturated drug solution stabilization potential of these polymers.Amorphous solid dispersions (ASDs) of etoricoxib were prepared with polyvinyl alcohol (PVA), polyvinyl
Prateek, Dani, Vibha, Puri, A K, Bansal
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KinetiSol®-Based Amorphous Solid Dispersions
2014KinetiSol is a novel fusion-based process for the production of amorphous solid dispersion systems that has been adapted for pharmaceutical processing from the plastics recycling industry. With its unique process attributes, KinetiSol is providing novel solutions for difficult-to-process poorly water-soluble compounds.
Dave A. Miller, Justin M. Keen
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Excipients for Amorphous Solid Dispersions
2014Pharmaceutical excipients play a significant role in stabilization of amorphous solid dispersions, as these systems are thermodynamically unstable. This chapter illustrates the challenges associated with amorphous solid dispersion stability and the role that excipients play in stabilization of amorphous solid dispersions by influencing the ...
Siva Ram Kiran Vaka +5 more
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Stability of Amorphous Solid Dispersion
2014Amorphous solid dispersion (ASD) has attracted tremendous attention in pharmaceutical development due to its characteristic solubility enhancement, thus positively affecting oral bioavailability of a range of hydrophobic drugs. Nevertheless, being in a metastable state, ASD has the intrinsic tendency of spontaneously reverting to a more stable ...
Xiang Kou, Liping Zhou
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Dissolution and Precipitation Behavior of Amorphous Solid Dispersions
Journal of Pharmaceutical Sciences, 2011Amorphous solid dispersions (ASDs) are widely utilized in the pharmaceutical industry for bioavailability enhancement of low solubility drugs. The important factors governing the dissolution behavior of these systems are still far from adequately understood.
David E, Alonzo +5 more
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Structural Characterization of Amorphous Solid Dispersions
2014Amorphous solid dispersions (ASD) stand on the forefront of solubilizing formulations for many poorly soluble drug candidates. It has been widely accepted that the physical stability, downstream processability, and performance of an ASD largely inherits its physical structure. The in-depth and multi-methodological characterization of ASD microstructure
Amrit Paudel +2 more
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Multifractal and mechanical analysis of amorphous solid dispersions
International Journal of Pharmaceutics, 2017The formulation of lipophilic and hydrophobic compounds is a challenge for the pharmaceutical industry and it requires the development of complex formulations. Our first aim was to investigate hot-melt extrudate microstructures by means of multifractal analysis using scanning electron microscopy imaging. Since the microstructure can affect solid dosage
Adler C, Teleki A, Kuentz M
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Dissolution Mechanisms of Amorphous Solid Dispersions
2023The dissolved concentration of an active pharmaceutical ingredient in biological fluids is of significant importance for establishing a therapeutic effect in patients. However, the current pharmaceutical landscape is abundant in poorly soluble drugs that require solubility enhancing techniques to enable their administration. A promising technique, with
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Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions
Current Pharmaceutical Design, 2014Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and ...
Chow, Albert H.L. +5 more
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Release Mechanisms of Amorphous Solid Dispersions
2022As the pharmaceutical industry moves towards molecular obesity with the use of high throughput screening for identification of promising candidates, the low aqueous solubilities of new chemical entities pose significant challenges to achieving adequate oral absorption and bioavailability.
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