Results 1 to 10 of about 166,305 (364)
Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
Biomolecules, 2020 It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
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Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]
PLoS ONE, 2014 Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chao-Yin Chen +3 more
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Channel opening and gating mechanism in AMPA-subtype glutamate receptors
Nature, 2017 AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system.
Edward C Twomey +2 more
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Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
Nature, 2017 Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory.
Kristin L Arendt +2 more
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Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Science, 2019 Diversity in ion channel complexes AMPA receptors are glutamate activated ion channels that mediate fast synaptic transmission in the nervous system and play a key role in learning and memory.
Yan Zhao +2 more
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AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model
Molecular Neurodegeneration, 2018 Background Extracellular aggregation of the amyloid-β (Aβ) peptide into toxic multimers is a key event in Alzheimer’s disease (AD) pathogenesis. Aβ aggregation is concentration-dependent, with higher concentrations of Aβ much more likely to form toxic ...
Jane C. Hettinger +4 more
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Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
Nature, 2021 Prashant Rao, Jaba Mitra
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X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Nature, 2009 Alexander I Sobolevsky, Eric Gouaux
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Bali Journal of Anesthesiology, 2022 Background: Unrelieved post-operative pain is an emerging healthcare concern with ever increasing global volume of surgical procedures. GluR1 subunit coupled with tumor necrosis factor (TNF)-α expression plays a major role in the development of post ...
Dewa Ayu Mas Shintya Dewi +3 more
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