Results 1 to 10 of about 89,264 (312)

Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors

Biomolecules, 2020
It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
doaj   +2 more sources

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

Molecular Neurodegeneration, 2018
Background Extracellular aggregation of the amyloid-β (Aβ) peptide into toxic multimers is a key event in Alzheimer’s disease (AD) pathogenesis. Aβ aggregation is concentration-dependent, with higher concentrations of Aβ much more likely to form toxic ...
Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman, John R. Cirrito   +4 more
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Physical stability and subjective efficacy study of liposome loaded with Clitoria ternatea (butterfly pea) flower extract and Eugenia caryophyllus (clove) oil [PDF]

Pharmaceutical Sciences Asia, 2022
Clitoria ternatea (butterfly pea) flower and Eugenia caryophyllus (clove) oil have been traditionally used as hair growth stimulating herbal and exhibited hair growth effects in vitro. This work prepared liposome loading with butterfly pea flower extract
Natchaporn Choochuen, Ampa Jimtaisong
doaj   +1 more source

Basil (Ocimum basilicum) Leaves Essential Oil Ameliorates GluR1 Receptor Expression, TNF-α Level, and Pain-like Behaviors in Post-operative Pain Setting

Bali Journal of Anesthesiology, 2022
Background: Unrelieved post-operative pain is an emerging healthcare concern with ever increasing global volume of surgical procedures. GluR1 subunit coupled with tumor necrosis factor (TNF)-α expression plays a major role in the development of post ...
Dewa Ayu Mas Shintya Dewi, Made Jawi, Nyoman Mantik Astawa, Christopher Ryalino   +3 more
doaj   +1 more source

Effects of Glyphosate and Its Metabolite AMPA on Aquatic Organisms

Applied Sciences, 2021
Glyphosate (N-(phosphonomethyl)glycine) was developed in the early 1970s and at present is used as a herbicide to kill broadleaf weeds and grass. The widely occurring degradation product aminomethylphosphonic acid (AMPA) is a result of glyphosate and ...
Nikola Třešňáková, A. Stara, J. Velíšek   +2 more
semanticscholar   +1 more source

Новый взгляд на патогенез депрессии: возможно ли появление быстродействующих антидепрессантов?

Современная терапия психических расстройств, 2020
Рекуррентное депрессивное расстройство является одним из самых распространенных и высокозатратных психических заболеваний в мире. На настоящий момент актуальна моноаминовая теория депрессии, однако открытие около 20 лет назад антидепрессивных свойств
Мосолов, С.Н., Федорова, Е.Ю.   +1 more
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Aluminium and calcium lake pigments of Lac natural dye

Brazilian Journal of Pharmaceutical Sciences, 2020
This work presents the physicochemical properties of the prepared lac lakes. The study revealed the stability, cytotoxicity and use of lac lake pigment as a cosmetic colorant. SEM, XRD and DSC were used to study the characteristics of the lac lakes.. The
Ampa Jimtaisong
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Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

Scientific Reports, 2021
Agonistic profiles of AMPA receptor (AMPA-R) potentiators may be associated with seizure risk and bell-shaped dose-response effects. Here, we report the pharmacological characteristics of a novel AMPA-R potentiator, TAK-653, which exhibits minimal ...
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura   +11 more
doaj   +1 more source

Glyphosate and AMPA levels in human urine samples and their correlation with food consumption: results of the cross-sectional KarMeN study in Germany

Archives of Toxicology, 2020
Glyphosate ( N -[phosphonomethyl]-glycine) is the most widely used herbicide worldwide. Due to health concerns about glyphosate exposure, its continued use is controversially discussed.
Sebastian T. Soukup, B. Merz, A. Bub, I. Hoffmann, B. Watzl, P. Steinberg, S. Kulling   +6 more
semanticscholar   +1 more source

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Arthritis Research & Therapy, 2021
Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modifications (PTMs) is
Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tom W. J. Huizinga, Theo Rispens, Hans U. Scherer, René E. M. Toes   +16 more
doaj   +1 more source