Results 111 to 120 of about 89,264 (312)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA- preferring glutamate receptors [PDF]

, 1994
Craig Blackstone, Timothy H. Murphy, S.J. Moss, Jay M. Baraban, RL Huganir   +4 more
openalex   +1 more source

Clinical and Neurodevelopmental Characteristics of Paralogous Gain‐of‐Function Variants at GRIA2 p.Gly792 and GRIA3 p.Gly803

Clinical Genetics, EarlyView.
Key features of paralogous GRIA2 and GRIA3 gain‐of‐function variants. ABSTRACT GRIA‐related disorders arise from disease‐causing variants in GRIA1, GRIA2, GRIA3, or GRIA4 that encode α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA)‐type glutamate receptors (AMPARs).
Emilie Sjøstrøm, Dorota Studniarczyk, Xinyao Dou, Rebekka S. Dahl, Vincent Cruz, Heng Wang, Sandra Mercier, Wallid Deb, Thomas Besnard, Jennifer Friedman, Miriam Essid, Sana Karoui, Lamia Ben Jemaa, Thouraya Benyounes, Gaetan Lesca, Davide Tonduti, Maria Iascone, Simona Orcesi, Melanie Fradin, Christèle Dubourg, Silvia Napuri, Stuart G. Cull‐Candy, Ian D. Coombs, Mark Farrant, Allan Bayat   +24 more
wiley   +1 more source

Determination of hydrophilic–lipophilic balance value and emulsion properties of sacha inchi oil

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To determine hydrophilic–lipophilic balance (HLB) value, stability of formulate emulsion and properties of sacha inchi oil. Methods: The physiochemical characteristics of sacha inchi oil were first investigated.
Kiattiphumi Saengsorn, Ampa Jimtaisong
doaj  

Potential of Psidium guajava Leaf as Natural UV Filter in Topical Sunscreen Emulsion

Journal of Applied Science and Engineering
This study aims to develop a sunscreen formulation using guava (Psidium guajava) leaf extract (GLE), obtained via ethanol-water (4:1 v/v) extraction. The crude extract was greenish-brown solid with a percentage yield of 19.88 ± 0.28.
Nalin Mora, Ampa Jimtaisong
doaj   +1 more source

Cyclothiazide unmasks AMPA‐evoked stimulation of [³H]‐L‐glutamate release from rat hippocampal synaptosomes [PDF]

, 1994
Janine M. Barnes, Kumlesh K. Dev, Jeremy M. Henley   +2 more
openalex   +1 more source

Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy

Epilepsia, EarlyView.
Abstract Objective Following emerging evidence of autoimmune‐associated seizures in medication‐refractory epilepsy, we began offering a trial of immunotherapy to selected patients. Here, we review this approach's treatment response, predictive clinical features, and utility.
Elisabeth Doran, Albert Kelly, Raluca Stanila, Laura Healy, Colin P. Doherty   +4 more
wiley   +1 more source

A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord [PDF]

, 1994
Boris A. Chizh, M. Cumberbatch, P.M. Headley   +2 more
openalex   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source