Results 81 to 90 of about 150,350 (378)
Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]
, 2011 Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena +5 more
core +1 more source
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
Science, 2016 Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory.
E. C. Twomey +4 more
semanticscholar +1 more source
p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
Nature Communications, 2019 AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge +10 more
doaj +1 more source
Development of AMPA Receptor Aptamers [PDF]
Biophysical Journal, 2010 The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) subtype of glutamate ion channel receptors plays an essential role in the mammalian brain activities such as memory and learning, whereas the excessive receptor activation has been implicated in neurological diseases such as stroke, epilepsy, and amyotrophic lateral sclerosis.
Zhen Huang +5 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors [PDF]
, 2000 NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional regulation at central excitatory synapses.
Kennedy, Mary B. +5 more
core +1 more source
Aging Cell, 2018 Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, although the molecular and cellular
D. Baglietto-Vargas +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim +5 more
wiley +1 more source
AMPA-Net: Optimization-Inspired Attention Neural Network for Deep Compressed Sensing [PDF]
2020 IEEE 20th International Conference on Communication
Technology(Oral), 2020 Compressed sensing (CS) is a challenging problem in image processing due to reconstructing an almost complete image from a limited measurement. To achieve fast and accurate CS reconstruction, we synthesize the advantages of two well-known methods (neural network and optimization algorithm) to propose a novel optimization inspired neural network which ...
arxiv
Scientific Reports, 2018 The establishment and maintenance of social dominance are critical for social stability and the survival and health of individual animals. Stress lead to depression and a decrease in the social status of depressed persons is a risk factor for suicide ...
Minjung Park +4 more
semanticscholar +1 more source