Results 91 to 100 of about 99,629 (284)

State based model of long-term potentiation and synaptic tagging and capture [PDF]

, 2009
Recent data indicate that plasticity protocols have not only synapse-specific but also more widespread effects. In particular, in synaptic tagging and capture (STC), tagged synapses can capture plasticity-related proteins, synthesized in response to ...
A Govindarajan, A Hayer, AB Barrett, Adam B. Barrett, AJ Heynen, AM Zhabotinsky, B Hille, CCH Petersen, CM O'Carroll, D Amit, DH O'Connor, EM Izhikevich, Guy O. Billings, H Okamoto, HK Lee, HZ Shouval, HZ Shouval, JE Lisman, JR Whitlock, JW Lin, KG Reymann, Lyle J. Graham, M Graupner, M Krug, Mark C. W. van Rossum, NH Woo, P Miller, P Smolen, R Fonseca, R Fonseca, R Fonseca, Richard G. M. Morris, S Li, S Sajikumar, S Sajikumar, S Sajikumar, S Sajikumar, S Sajikumar, SJ Martin, SM Dudek, T Dunwiddie, U Frey, U Frey, U Frey, U Frey, U Staubli, W Senn, WC Abraham, WC Abraham, WS Sossin, Y Yao   +50 more
core   +4 more sources

C‐Acylation of Guaiacol with Acetic Acid Over Solid Acid Catalysts Under Mild Reaction Conditions

ChemCatChem, EarlyView.
Direct acylation of guaiacol (G) with acetic acid (AA) over Aquivion® PW87 under mild conditions affords 4‐hydroxy‐3‐methoxyacetophenone (p‐HMAP) with a remarkable para/ortho molar ratio of 26:1. Combined DFT and experimental studies reveal an acid‐catalyzed intermolecular acyl transfer via 2‐methoxyphenyl acetate (MPA), enabling a highly selective and
Nicola Schiaroli, Francesca Foschi, Massimo Mella, Carlo Lucarelli   +3 more
wiley   +1 more source

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

Cytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia   +2 more
wiley   +1 more source

Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities

Disease Models & Mechanisms, 2019
Loss-of-function mutations in a human AMPA receptor-associated protein, ferric chelate reductase 1-like (FRRS1L), are associated with a devastating neurological condition incorporating choreoathetosis, cognitive deficits and epileptic encephalopathies ...
Michelle Stewart, Petrina Lau, Gareth Banks, Rasneer Sonia Bains, Enrico Castroflorio, Peter L. Oliver, Christine L. Dixon, Michael C. Kruer, Dimitri M. Kullmann, Abraham Acevedo-Arozena, Sara E. Wells, Silvia Corrochano, Patrick M. Nolan   +12 more
doaj   +1 more source

Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation [PDF]

, 2017
This study investigated the combination of environmental enrichment (EE) with cocaine‐cue extinction training on reacquisition of cocaine self‐administration.
Dhonnchadha, Brid Aine Nic, Gauthier, Jamie M., Kantak, Kathleen M., Lin, Amy, Man, Heng-Ye, Spealman, Roger D.   +5 more
core   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments [PDF]

, 2003
Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA).
Allen, Patrick B., Benfenati, Fabio, Greengard, Paul, Hsieh-Wilson, Linda C., Nairn, Angus C., Snyder, Gretchen L.   +5 more
core  

Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy

Epilepsia Open, EarlyView.
Abstract Epilepsy is primarily defined by the repetitive occurrence of seizures, but the full impact of seizures extends beyond these episodic events. Seizures themselves cause changes at the cellular, network, and systemic levels in individual patients with epilepsy and may contribute to the progressive nature of the disease in some patients. Seizures
Matthew C. Walker, Marian Galovic, Elena Álvarez‐Barón, Adam Strzelczyk   +3 more
wiley   +1 more source

LTD expression is independent of glutamate receptor subtype

Frontiers in Synaptic Neuroscience, 2014
Long-term depression (LTD) is a form of synaptic plasticity that plays a major role in the activity-dependent reshaping of synaptic transmission.
Adam J Granger, Roger A Nicoll
doaj   +1 more source