Results 91 to 100 of about 2,334,241 (398)

Large number of receptors may reduce cellular response time variation [PDF]

Physical biology 10 (3), 035008, 2013, 2012
Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv   +1 more source

AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury. [PDF]

, 2015
Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms ...
Beattie, Michael S, Bresnahan, Jacqueline C, Ferguson, Adam R, Grau, James W, Huie, J Russell, Irvine, Karen-Amanda, Lee, Kuan H, Stuck, Ellen D   +7 more
core   +1 more source

Seizure control by decanoic acid through direct AMPA receptor inhibition

Brain : a journal of neurology, 2015
See Rogawski (doi:10.1093/awv369) for a scientific commentary on this article.  The MCT ketogenic diet, an established treatment for drug-resistant epilepsy, leads to an elevation of plasma decanoic acid and ketones. Chang et al. show that decanoic acid,
P. Chang, Katrin Augustin, Kim Boddum, Sophie Williams, Minghao Sun, J. Terschak, J. Hardege, Philip E. Chen, M. Walker, Robin S. B. Williams   +9 more
semanticscholar   +1 more source

Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top–Down Circuit

Advanced Science, EarlyView.
The anterior piriform cortex (APC) exhibits distinct neural firings and calcium transients in response to familiar and novel mice, with a more robust response to the novel one. Selectively inhibiting APC pyramidal neurons disrupt social novelty recognition without impairing basic odor discrimination.
Jingwei Zhou, Zhaoyang Yin, Zhiyun Chen, Hanyu Fu, Qun Li, Shan Li, Ying Zhang, Xianzhi Zhang, Dewei Tang, Anan Li, Dejuan Wang   +10 more
wiley   +1 more source

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Cell Reports, 2023
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan, Se Eun Jang, Ana Batallas-Borja, Nishita Bhembre, Mintu Chandra, Lingrui Zhang, Huimin Guo, Mitchell T. Ringuet, Jocelyn Widagdo, Brett M. Collins, Victor Anggono   +10 more
doaj  

Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]

, 2017
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core   +3 more sources

Pathogenic Mechanism of an Autism-Associated Neuroligin Mutation Involves Altered AMPA-Receptor Trafficking

Molecular Psychiatry, 2015
Neuroligins are postsynaptic cell-adhesion molecules that bind to presynaptic neurexins. Although the general synaptic role of neuroligins is undisputed, their specific functions at a synapse remain unclear, even controversial.
Soham Chanda, Jason Aoto, Sung-Jin Lee, Marius Wernig, T. Südhof   +4 more
semanticscholar   +1 more source

Allosteric competition and inhibition in AMPA receptors

Nature Structural & Molecular Biology, 2023
AbstractExcitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through unresolved ...
W. Dylan Hale, Alejandra Montaño Romero, Cuauhtemoc U. Gonzalez, Vasanthi Jayaraman, Albert Y. Lau, Richard L. Huganir, Edward C. Twomey   +6 more
openaire   +3 more sources

Cell‐Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory

Advanced Science, EarlyView.
Li et al. defined two novel glutamatergic neuronal subtypes in the medial mammillary nucleus, pars lateralis‐located parvalbumin (PV) neurons, and basalis‐located Drd2 neurons. PV and Drd2 neurons differ in their electrophysiological properties encoded by Kcnn4 and Cacna1h, and selectively modulate place and object recognition memory by two distinct ...
Lanfang Li, Yiqing Guo, Wei Jing, Xiaomei Tang, Jinyu Zeng, Zhenye Hou, Yige Song, Aodi He, Hao Li, Ling‐Qiang Zhu, Youming Lu, Xinyan Li   +11 more
wiley   +1 more source

Coupled feedback loops maintain synaptic long-term potentiation: A computational model of PKMzeta synthesis and AMPA receptor trafficking [PDF]

, 2017
In long-term potentiation (LTP), one of the most studied types of neural plasticity, synaptic strength is persistently increased in response to stimulation. Although a number of different proteins have been implicated in the sub-cellular molecular processes underlying induction and maintenance of LTP, the precise mechanisms remain unknown. A particular
arxiv   +1 more source