Results 111 to 120 of about 50,502 (231)

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala, Gabriel Eduardo Guzmán‐López, Annia Galano   +2 more
wiley   +1 more source

Mimicking Silent Synapse Recruitment: A SiOx/Cu‐Pancake Memristive Device For Analog Neuromorphic Computing

Advanced Functional Materials, Volume 36, Issue 63, 6 August 2026.
Electroforming‐free TiN/SiOx/Cu/SiOx/TiN memristive devices exploit pancake‐like Cu nanoparticles embedded in a SiOx double layer to create a heterogeneous Schottky‐barrier landscape. Under bias, oxygen‐vacancy redistribution progressively lowers local barriers and recruits initially inactive Cu‐PC pathways into a parallel conduction ensemble, enabling
Rouven Lamprecht, Ole Gronenberg, Sahitya Yarragolla, Tobias Gergs, Richard Marquardt, Victor Witte, Jürgen Carstensen, George Popkirov, Jan Trieschmann, Lorenz Kienle, Hermann Kohlstedt   +10 more
wiley   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Dorsal raphe tau pathology disrupts sleep‐wake orchestration and sleep architecture in a sex‐specific manner

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Sleep disturbances are frequent symptoms of Alzheimer's disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative contributions of serotonin (5‐HT) and sex, has not been directly tested.
Louis J. Kolling, Ruixiang Wang, Gabriel S. Gaudencio, Jamie S. Fishbeyn, Thomas D. James, Suzanne M. Mason, Riley O. McCoy, Zhimin Song, Ian Pascal McConnell, Kylie Ziemke, Kasia M. Janik, Yu Xu, Gabrielle Bierlein‐De La Rosa, Shafa Ismail, Catherine Anne Marcinkiewcz   +14 more
wiley   +1 more source

A plasma‐based protein signature combining NPTXR, ACHE, and p‐tau217 predicts progression to symptomatic Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Overview of the study design and analytical workflow. Plasma samples from cognitively unimpaired (CU) participants were analyzed to evaluate progression to symptomatic Alzheimer's disease (AD), and additional analyses examined progression from mild cognitive impairment (MCI) to AD and cross‐sectional disease severity.
Menghan Liu, Katherine Gong, Yike Chen, Gyujin Heo, Ying Xu, Jigyasha Timsina, Daniel Western, John Budde, John C. Morris, Giorgetti Marco, David M. Holtzman, Jeremiah Hinson, Scott Levin, Nicholas Ashton, Marisa Denkinger, Suzanne E. Schindler, Kausik Das, Muhammad Ali, Carlos Cruchaga   +18 more
wiley   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

An Olfactory Piriform Cortex‐Lateral Hypothalamus Neural Circuit Contributes to Linalool‐Induced Analgesia

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Linalool odor exposure activates a glutamatergic projection from the piriform cortex to the lateral hypothalamus (PiriGlu‐LH), mediating descending inhibitory pain pathways. This demonstrates a novel neural mechanism for olfactory‐induced pain modulation and suggests potential therapeutic implications for pain management.
Yunhe Zhu, Jingping Sun, Shan Wang, Qidong Zhang, Jian Mao, Guobi Chai, Qingzhao Shi, Wu Fan, Jianping Xie   +8 more
wiley   +1 more source

Bard1‐Mediated Regulation of Hnrnpa2b1 Ubiquitination and Protein Stability Contributes to Neuronal Ferroptosis and Cognitive Dysfunction Following Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Bard1‐mediated ubiquitination of Hnrnpa2b1 in mice with PSCI destabilizes Sptbn2, which prevents the membrane translocation of Slc7a11 and reduces cystine uptake. This disruption of antioxidant defense triggers ferroptosis in hippocampal neurons, highlighting a novel molecular pathway linking post‐stroke cognitive impairment to ferroptosis of ...
Tuming Li, Tianyi Rong, Zuoting Shen, Zhenyu Wei, Deyan Chen, Ping Zhong, Li Cao   +6 more
wiley   +1 more source

Claudin 24-A novel enhancer of AMPA receptor fidelity. [PDF]

Sci Adv
Strasdeit T, Amin E, Obst S, Biermann B, Newton TP, Kösters SC, Schouwink M, Fedotov S, Shaukat J, Bhattacharya S, Aslam M, Anstötz M, Okka FN, Sevillano Quispe OG, Bouvain P, Vedyashkin J, Sobolevsky AI, Traynelis SF, von Engelhardt J, Erlenhardt N, Hollmann M, Klöcker N.   +21 more
europepmc   +1 more source