Results 111 to 120 of about 58,960 (255)
All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants
Pharmacological ResearchTreatment-resistant depression (TRD) represents a major clinical challenge. Affecting about 30 % of major depressive disorder (MDD) patients, effective treatments for TRD are urgently needed.
Florian Freudenberg +4 more
doaj +1 more source
LTD expression is independent of glutamate receptor subtype
Frontiers in Synaptic Neuroscience, 2014 Long-term depression (LTD) is a form of synaptic plasticity that plays a major role in the activity-dependent reshaping of synaptic transmission.
Adam J Granger, Roger A Nicoll
doaj +1 more source
Comparison of AMPA receptor densities.
, 2014 A) A raw electron micrograph image of SDS-FRL replica immunolabeled with pan-AMPA antibody (left), and an analyzed image (right). A representative replica from a wild type mouse treated with saline (WT-Sal) is shown.
Hongrui Meng (636865) +6 more
core +1 more source
Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping
The Chemical Record, EarlyView.Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato +3 more
wiley +1 more source
An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda +6 more
wiley +1 more source
AMPA Receptor Trafficking at Excitatory Synapses
, 2003 Excitatory synapses in the CNS release glutamate, which acts primarily on two types of ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the postsynaptic depolarization that initiates neuronal firing, whereas NMDA receptors ...
David S Bredt +3 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
wiley +1 more source
AMPA receptor regulation mechanisms: future target for safer neuroprotective drugs
, 2004 The post-synaptic AMPA receptors play an important role in mediating fast excitatory transmission in the mammalian brain. Over-activated AMPA receptors induce excitotoxicity, implicated in a number of chronic neurodegenerative disorders such as ...
Dikshit, Madhu, Jayakar, Selwyn S.
core +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
AMPA Receptor Trafficking in Schizophrenia
, 2011 The glutamate hypothesis of schizophrenia is based primarily on NMDA receptor dysfunction. Recent studies have led to an expansion of this hypothesis to include AMPA receptors which are essential for neurotransmission through NMDA receptors.
Hammond, John
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