Results 121 to 130 of about 50,502 (231)

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, Volume 11, Issue 4, Page 1095-1110, August 2026.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Sex differences in AMPA receptor trafficking proteins. [PDF]

Biol Sex Differ
Roberts MY, Briand LA.
europepmc   +1 more source

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug‐resistant focal epilepsy

Epilepsia Open, Volume 11, Issue 4, Page 1171-1183, August 2026.
Abstract Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB treatment.
Silvano R. Gefferie, Diego Jiménez‐Jiménez, Gerhard H. Visser, Robert M. Helling, Arn M. J. M. van den Maagdenberg, Josemir W. Sander, Simona Balestrini, Roland D. Thijs   +7 more
wiley   +1 more source

Native AMPA receptor architecture reveals SynDIG4 engagement and auxiliary subunit heterogeneity. [PDF]

Sci Adv
Fang C, Gouaux E.
europepmc   +1 more source

Perampanel as add‐on in high‐grade glioma–related epilepsy: Seizure control and QoL in a prospective, multicenter, real‐world 6‐month follow‐up study

Epilepsia Open, Volume 11, Issue 4, Page 1137-1148, August 2026.
Abstract Objective High‐grade astrocytomas, including glioblastomas, are aggressive brain tumors with poor prognosis and a 5‐year survival below 7%. Seizures affect up to 75% of glioma patients, especially in low‐grade tumors but also in high‐grade cases.
Matteo Impellizzeri, Paolo Paone, Giada Pauletto, Annacarmen Nilo, Simone Beretta, Andrea Salmaggi, Stefano Consoli, Stefano Quadri   +7 more
wiley   +1 more source

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

Epilepsia Open, Volume 11, Issue 4, Page 1329-1342, August 2026.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster, Lyn Millist, Jack Germaine, Stephanie Chamorro, Caitlin Roberts, John‐Paul Nicolo, Sean Hosking, Piero Perucca, Saul Mullen, Heather Robinson, Rebecca Wharrie, Brittany Walsh, David Reutens, Kimberley Irwin, Hao Zeng, Robert Niecestro, Terence J. O'Brien   +16 more
wiley   +1 more source

Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM. [PDF]

Protein Sci
Park J, Gouaux E.
europepmc   +1 more source

Early Developmental Neuronal Activity Impacts Oligodendrocyte Differentiation Through AMPA Receptors

Glia, Volume 74, Issue 8, August 2026.
In early brain development, neuronal activity reduces OPC differentiation. Decreased neuronal activity changes oligodendrocyte gene expression, including upregulating glutamate receptor genes. AMPA signaling regulates the final stages of OPC differentiation.
Tessa E. Allen, Graham Peet, Luis E. Gomez Wulschner, Won Chan Oh, Wendy B. Macklin   +4 more
wiley   +1 more source

Structural basis for activation and conformational plasticity of the GluA4 AMPA receptor. [PDF]

Nat Commun
Hale WD, Wang H, Huganir RL, Twomey EC.
europepmc   +1 more source

Advancement of Peptide‐PAINT: Applications and Current Challenges in Super‐Resolution Imaging

Small Science, Volume 6, Issue 8, August 2026.
Peptide‐PAINT is rapidly emerging as a powerful single‐molecule super‐resolution imaging platform, enabling molecular visualization with ~5–10 nm localization precision. This review critically discusses its underlying principles, recent biological applications, technological limitations, and key challenges, while benchmarking its strengths and ...
Devi Prasanna Behera, Ritesh Sonar, Ahenjeeta Ghosh, Barun Kumar Maity   +3 more
wiley   +1 more source