Results 141 to 150 of about 94,530 (267)
Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó +4 more
wiley +1 more source
Noise‐induced reduction and early recovery of superior paraolivary nucleus sound‐offset responses
The Journal of Physiology, EarlyView.Abstract figure legend Acoustic over‐exposure transiently disrupts auditory temporal processing in mouse superior paraolivary nucleus neurons. In control conditions, neurons exhibit robust sound‐offset (OFF) responses, which are abolished immediately following noise trauma, indicating impaired temporal encoding.
Mihai Stancu +4 more
wiley +1 more source
Hypoxia‐induced vulnerability of the somatosensory nervous system
The Journal of Physiology, EarlyView.Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley +1 more source
Developmental Profiling of Structural and Functional Maturation in Mouse Corpus Callosum
Glia, Volume 74, Issue 6, June 2026.Progressive myelin development in mouse corpus callosum is accompanied by gradual decrease in oligodendrocyte precursor cell density and increase in oligodendrocyte density. Pro‐Capase‐3 is transiently upregulated in oligodendrocyte during postnatal development.
Hayes Johnson +4 more
wiley +1 more source
Transport of BMAA into Neurons and Astrocytes by System x\u3csub\u3ec\u3c/sub\u3e- [PDF]
, 2018 The study of the mechanism of β-N-methylamino-l-alanine (BMAA) neurotoxicity originally focused on its effects at the N-methyl-d-aspartate (NMDA) receptor. In recent years, it has become clear that its mechanism of action is more complicated.
Albano, Rebecca, Lobner, Doug
core +1 more source
Brivaracetam‐associated manic episode in a patient with bipolar disorder: A case report
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.A patient with Bipolar I disorder developed manic symptoms following the initiation of brivaracetam for focal epilepsy. Although brivaracetam is generally considered to have favorable psychiatric tolerability, this case highlights a potential risk of mood destabilization in patients with underlying bipolar disorder.
Mihoko Kawai +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 12, Page 3340-3354, June 2026.Background and Purpose Ketamine consists of two enantiomers, (R)‐ketamine and (S)‐ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)‐enantiomer has been approved for the treatment of major depressive disorder, whereas recent clinical studies have failed to demonstrate an antidepressant effect for (R)‐ketamine.
Szabolcs Koncz +4 more
wiley +1 more source
Traffic, Volume 27, Issue 2, June 2026.Loss of the cargo receptor Erv14 in Saccharomyces cerevisiae results in sensitivity to calcium, zinc, neutral extracellular pH, and elevated temperature. Furthermore, cells deleted in the ERV14 exhibits vacuolar fragmentation, enlarged lipid droplets, and metabolic alterations. Ruiz Salas, J. L. (2026) https://BioRender.com/b65g523. ABSTRACT Erv14 is a
Paul Rosas‐Santiago +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber +12 more
wiley +1 more source
Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract BACKGROUND Genetic variants affecting microglial function can influence Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear. The AD‐associated ABI3S209F (Abi3S212F in mouse) variant regulates cytoskeletal dynamics, but its in vivo impact on pathology is unknown. METHODS: An Abi3S212F mouse was developed and crossed with
Claire A. Butler +29 more
wiley +1 more source