Results 151 to 160 of about 1,291,656 (247)

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza, Renato W. Martins Sá, Luiza Henrique de Souza, Fernando S. Ramalho, Davi J. A. Moraes   +4 more
wiley   +1 more source

Reduction in membrane AMPA receptor subunit 2 in left prefrontal cortex correlates with post-stroke depression. [PDF]

Neurotherapeutics
Yu Y, Fu R, Rong H, Fang Q.
europepmc   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Claudin 24-A novel enhancer of AMPA receptor fidelity. [PDF]

Sci Adv
Strasdeit T, Amin E, Obst S, Biermann B, Newton TP, Kösters SC, Schouwink M, Fedotov S, Shaukat J, Bhattacharya S, Aslam M, Anstötz M, Okka FN, Sevillano Quispe OG, Bouvain P, Vedyashkin J, Sobolevsky AI, Traynelis SF, von Engelhardt J, Erlenhardt N, Hollmann M, Klöcker N.   +21 more
europepmc   +1 more source

Persisting Region‐Specific Microglia Activation and Synaptic Imbalance During Remission in a DSS‐Induced Colitis Model

Glia, Volume 74, Issue 11, November 2026.
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton, Luis E. Villafuerte, Alejandra P. Garza, Nina Lindemann, Elisa Wider‐Eberspächer, Dunja Bruder, Ildiko R. Dunay   +6 more
wiley   +1 more source

AMPA receptor modulation in depression: from molecular mechanisms of plasticity to therapeutic translation. [PDF]

Pharmacol Rep
Ziemichód W, Kajka N, Kister K, Kasprzak K, Karakuła K, Juchnowicz D.   +5 more
europepmc   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3534-3545, October 2026.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source

Sex differences in AMPA receptor trafficking proteins. [PDF]

Biol Sex Differ
Roberts MY, Briand LA.
europepmc   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Native AMPA receptor architecture reveals SynDIG4 engagement and auxiliary subunit heterogeneity. [PDF]

Sci Adv
Fang C, Gouaux E.
europepmc   +1 more source