Results 151 to 160 of about 58,960 (255)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, Volume 183, Issue 14, Page 3897-3919, July 2026.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, Volume 183, Issue 14, Page 4022-4047, July 2026.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Learning Dynamics in Biophysical Spiking Network Models Are Shaped by KCC2/NKCC1 Cotransporter Stoichiometry

European Journal of Neuroscience, Volume 64, Issue 1, July 2026.
Neuronal chloride homeostasis, governed by KCC2 and NKCC1 cotransporters, constrains convergence to learning in biophysical spiking neural networks. Systematic exploration of transporter activity shows that successful learning emerges only within a restricted parameter regime, whose boundaries and convergence properties critically depend on NKCC1 ...
Mohamed Ahmed, Antônio‐Carlos Guimarães de Almeida, Antônio Márcio Rodrigues, Damien Depannemaecker   +3 more
wiley   +1 more source

Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs [PDF]

, 2004
Ashby, MC, Collingridge, Graham L, Henley, Jeremy, Uney, James, De La Rue, Sarah A, Ralph, GS   +5 more
core   +1 more source

Impact of Voluntary Alcohol Consumption on Corticostriatal Plasticity in Rats

European Journal of Neuroscience, Volume 64, Issue 1, July 2026.
After 8 weeks voluntary alcohol consumption, AMPA/NMDA ratios were reduced in medium spiny neurons in the dorsolateral striatum, upon optogenetic stimulation of sensorimotor cortical inputs. Moreover, coefficient of variance was reduced and paired‐pulse facilitation was enhanced, selectively in high alcohol drinking rats.
Johanna A. S. Smeets, Geert M. J. Ramakers, Frank J. Meye, Anne‐Marie Baars, Roger A. H. Adan, Louk J. M. J. Vanderschuren, Heidi M. B. Lesscher   +6 more
wiley   +1 more source

Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain

, 2013
Brain damage caused by an acute injury depends on the initial severity of the injury and the time elapsed after the injury. To determine whether these two variables activate common mechanisms, we compared the response of the rat medial septum to insult ...
Andrés, N., Prats Galino, Alberto, Pugliese, Marco, Rodríguez Allué, Manuel José, Mahy Gehenne, Josette Nicole, Malpesa, Y., Batlle, Montserrat   +6 more
core  

Claudin 24-A novel enhancer of AMPA receptor fidelity. [PDF]

Sci Adv
Strasdeit T, Amin E, Obst S, Biermann B, Newton TP, Kösters SC, Schouwink M, Fedotov S, Shaukat J, Bhattacharya S, Aslam M, Anstötz M, Okka FN, Sevillano Quispe OG, Bouvain P, Vedyashkin J, Sobolevsky AI, Traynelis SF, von Engelhardt J, Erlenhardt N, Hollmann M, Klöcker N.   +21 more
europepmc   +1 more source

Native AMPA receptor architecture reveals SynDIG4 engagement and auxiliary subunit heterogeneity. [PDF]

Sci Adv
Fang C, Gouaux E.
europepmc   +1 more source

Sex differences in AMPA receptor trafficking proteins. [PDF]

Biol Sex Differ
Roberts MY, Briand LA.
europepmc   +1 more source

Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM. [PDF]

Protein Sci
Park J, Gouaux E.
europepmc   +1 more source