Results 161 to 170 of about 1,291,656 (247)

Cell Type‐Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment

Glia, Volume 74, Issue 10, October 2026.
Cell type–specific EVs were isolated from mouse brain and profiled by proteomics. Each EV subtype exhibited proteomic signatures consistent with the specialized functions of its cell of origin. Astrocyte‐derived EVs (ADEVs) were enriched for the GlialCAM/MLC1 network and GPCRs.
Alba M. Lucart‐Sanchez, Edward Sellés‐Climent, Jorge Navarro‐Calvo, Guillem Pont‐Espinós, Jose A. Gomez‐Sanchez, Raúl Estévez, Luis M. Valor, Rocío Pérez‐González   +7 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Age and sex-dependent alteration in AMPA receptor density in living human brain. [PDF]

Eur J Nucl Med Mol Imaging
Hatano M, Nakajima W, Tsuchimoto S, Arisawa T, Takada Y, Eiro T, Abe H, Ichijo S, Fujimoto Y, Sano A, Syed SA, Tani H, Nagai N, Koizumi T, Nakajima S, Nomoto-Takahashi K, Ohtani Y, Jinzaki M, Hirano Y, Mitoma R, Tamura S, Baba S, Togao O, Kosaka H, Okazawa H, Kimura Y, Mimura M, Uchida H, Takahashi T.   +28 more
europepmc   +1 more source

Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Aged mice exhibited impaired motor behavior and neuromuscular hypoexcitability, yet cortical output to muscle was enhanced, and motor cortex layer V pyramidal neurons were hyperexcitable, with altered synaptic inputs and excitability‐related transcriptional changes.
Jose A. Viteri, Nathan R. Kerr, Fereshteh B. Darvishi, Anna Roshani Dashtmian, Charles D. Brennan, Sindhuja N. Ayyagari, Peter J. Moore, Meifang Wang, Harper Snyder, Baocong Yu, Joseph M. Santin, W. David Arnold   +11 more
wiley   +1 more source

TRIM8 Promotes Epileptiform Activity by Destabilizing the Glucocorticoid Receptor NR3C1 and Enhancing AMPA Receptor Phosphorylation. [PDF]

Biomedicines
Li X, Jia Y, Fang B, Xu M, Xie X, Lu X.
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM. [PDF]

Protein Sci
Park J, Gouaux E.
europepmc   +1 more source

Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions

European Journal of Neuroscience, Volume 64, Issue 7, October 2026.
Oligodendrocyte progenitor cells (OPCs) are increasingly recognised as multifunctional CNS cells rather than mere precursors of myelinating oligodendrocytes. Alongside myelination and remyelination, they contribute to myelin and circuit plasticity, circuit regulation, vascular and blood–brain barrier regulation and neuroimmune modulation.
Alerie G. de la Fuente
wiley   +1 more source

Antioxidant, antimicrobial, and AMPA receptor modulatory activities of selected medicinal plant extracts reveal multitarget pharmacological potential. [PDF]

Sci Rep
Qneibi M, Rahhal B, Jaradat N, Hawash M, Qadi M, Issa L, Rajab S, Feras Y, Bairat N, Bdir S, Bdair M, Aldwaik SA, Mudalal S.   +12 more
europepmc   +1 more source

Neurofluid Biomarker Sensors: Integrated Design Strategies From Molecular Recognition to Precision Neurological Diagnosis

Advanced Sensor Research, Volume 5, Issue 9, September 2026.
This review focuses on the principles and signal mechanisms of four types of neurofluid biomarker sensors (electrochemical, optical, mechanical, and multimodal), summarizes the detection strategies for biomarkers such as ions, neurotransmitters, metabolites, and inflammatory proteins and their applications in the diagnosis and treatment of neurological
Ting Li, Guoying Pan, Yuheng Wang, Xin Zou, Hui Yang   +4 more
wiley   +1 more source