Results 111 to 120 of about 99,629 (284)

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
wiley   +1 more source

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti‐Related Peptide (NPY/AgRP) Neurons

Obesity, EarlyView.
ABSTRACT Objective Topiramate is a medication used off‐label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.
Moein Minbashi Moeini, Olivier Lavoie, Alexandre Caron, Kevin W. Williams, Natalie J. Michael   +4 more
wiley   +1 more source

Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model

Neuroscience Research
NMDA and AMPA receptors are co-localized at most glutamatergic synapses, where their numbers and distribution undergo dynamic changes. Glutamate binds to both the NMDA and AMPA receptors.
Qingchen Guo
doaj   +1 more source

Multi‐Channel Neural Interface for Neural Recording and Neuromodulation

Small Methods, EarlyView.
This review highlights recent advances in multi‐channel neural interface technologies, covering both high‐resolution electrophysiological recording systems and multifunctional platforms with integrated capabilities. It also discusses innovations in structure and materials for reduced invasiveness, state‐of‐the‐art data analysis, including machine ...
Eunmin Kim, Won Gi Chung, Enji Kim, Myoungjae Oh, Joonho Paek, Taekyeong Lee, Dayeon Kim, Seung Hyun An, Sumin Kim, Jang‐Ung Park   +9 more
wiley   +1 more source

NMDA Induces Long-Term Synaptic Depression and Dephosphorylation of the GluR1 Subunit of AMPA Receptors in Hippocampus [PDF]

, 1998
Hey‐Kyoung Lee, Kimihiko Kameyama, Richard L. Huganir, Mark F. Bear   +3 more
openalex   +1 more source

Mechanism of Ammonia‐Induced Brain Damage in Chinese Striped‐Necked Turtle (Mauremys sinensis)

Integrative Zoology, EarlyView.
High levels of ammonia disrupt the integrity of the brain barrier in Mauremys sinensis, leading to tissue edema. This, in turn, triggers a series of cascade reactions, including disturbances in neurotransmitter levels, particularly glutamate, which might further exacerbate the neurotoxic effects.
Yunjuan Xiao, Xin Niu, Xueting Jiao, Liangping Lin, Haitao Shi, Meiling Hong, Li Ding   +6 more
wiley   +1 more source

Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP [PDF]

, 1998
Shalini Srivastava, Pavel Osten, Ferdinand S. Vilim, Latika Khatri, Gareth J. Inman, Bradley A. States, Christopher Daly, Sunita deSouza, Ruben Abagyan, J.G. Valtschanoff, Richard J. Weinberg, Edward B. Ziff   +11 more
openalex   +1 more source

Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease‐Like Brain Transcriptomic Signatures in AppNL‐G‐F Mice

Aging Cell, EarlyView.
Choline‐protected genes correlated with clinical dementia rating, inflammation, and tauopathy in human AD samples, suggesting that adequate choline intake could be a preventive strategy for Alzheimer's disease (AD). ABSTRACT Alzheimer's disease (AD)—the leading cause of dementia—has no cure, inadequate treatment options, and a limited understanding of ...
Thomas A. Bellio, Andre Krunic, Mary S. Campion, Rohan Dupaguntla, Adam Labadorf, Thor D. Stein, Honghuang Lin, Tiffany J. Mellott, Jan K. Blusztajn   +8 more
wiley   +1 more source