Results 181 to 190 of about 2,334,241 (398)
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Neurobiology of Disease, 1994 A minority subset of cortical neurones exhibit kainate-activated Co2+uptake, a marker for AMPA/kainate receptor gated Ca2+-permeable channels. Consistent with enhanced Ca2+influx through these channels, Co2+-positive neurones are unusually vulnerable to ...
Hong-zhen Yin +3 more
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AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging
Dialogues in Clinical Neuroscience, 2013 Even in healthy individuals there is an inexorable agerelated decline in cognitive function. This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular composition of the postsynaptic membrane.
J. Henley, K. Wilkinson
semanticscholar +1 more source
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, EarlyView.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP [PDF]
, 1998 Shalini Srivastava +11 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez +17 more
wiley +1 more source
Mechanism for neurotransmitter-receptor matching. [PDF]
, 2020 Synaptic communication requires the expression of functional postsynaptic receptors that match the presynaptically released neurotransmitter. The ability of neurons to switch the transmitter they release is increasingly well documented, and these ...
Glavis-Bloom, Alex +3 more
core +1 more source
Establishment and characterization of adap1‐deficient zebrafish
Development, Growth &Differentiation, EarlyView.To examine the physiological functions of the adap1 gene, we have established zebrafish adap1 mutants lacking functional PH1 and PH2 domains. The adap1 mutants showed no apparent morphological abnormalities and grew to adulthood. We found that the adult adap1 mutants spent more time than the wild type in the regions near the chambers where novel ...
Atsuo Kawahara +7 more
wiley +1 more source
A novel therapeutic approach for treatment of catamenial epilepsy
Neurobiology of Disease, 2018 Many women with epilepsy experience perimenstrual seizure exacerbation, referred to as catamenial epilepsy. There is no effective treatment for this condition, proposed to result from withdrawal of neurosteroid-mediated effects of progesterone.
Suchitra Joshi +5 more
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