Results 191 to 200 of about 99,629 (284)

Fusion Pores as Regulators of Quantal Size and Cellular Physiology

BioEssays, Volume 47, Issue 11, November 2025.
During regulated exocytosis, membrane fusion regulatory factors act directly on SNAREs and membrane lipids to control fusion pore dynamics. This, in turn, leads to a differential amount of cargo release (referred to in this article as “quantal size”) across various cell types, thereby triggering distinct physiological cues.
Bhavya R. Bhaskar, Shahina Mazumdar, Sruthilaya Dayanandan, Debasis Das   +3 more
wiley   +1 more source

Developmental changes in synaptic AMPA and NMDA receptor distribution and AMPA receptor subunit composition in living hippocampal neurons. [PDF]

, 2000
Lisa Pickard, Jacques Noël, Jeremy M. Henley, Graham L. Collingridge, Elek Molnár   +4 more
openalex   +2 more sources

Signaling by intracellular β₂-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity. [PDF]

Cell Rep
Lee B, Xing X, Hammes EA, Zeng Z, Estrada-Tobar ZM, Kim K, Ireton KE, Mimi Man KN, Jacobi AA, Berumen RA, Weiner JC, Shen A, Xu B, Wang J, Gasser PJ, Navedo MF, Xiang YK, Díaz E, Chen CY, Horne MC, Hell JW.   +20 more
europepmc   +1 more source

EFFECTS OF AMPA/KA RECEPTOR BLOCKADE ON D1 AND D2-LIKE DA RECEPTOR MEDIATED EFFECTS IN NAS CORE AND SHELL

, 1998
Kyoung Ho Choi, Glen B. Baker, Andrew J. Greenshaw   +2 more
openalex   +1 more source

AMPA Receptor-Mediated, Calcium-Dependent CREB Phosphorylation in a Subpopulation of Auditory Neurons Surviving Activity Deprivation [PDF]

, 2000
Lance Zirpel, Mary A. Janowiak, Charles A. Veltri, Thomas N. Parks   +3 more
openalex   +1 more source

Effectiveness and Safety of Perampanel in Refractory Focal Epilepsy: Real‐World Evidence From a Chinese Cohort

Brain and Behavior, Volume 15, Issue 11, November 2025.
This retrospective real‐world study of 190 Chinese patients with refractory focal epilepsy demonstrated that adjunctive PER achieved sustained responder rates (∼66%) and seizure freedom (∼27%) over 12 months, with an acceptable safety profile. Male gender, higher doses, and late add‐on predicted better outcomes, while adults experienced fewer adverse ...
Tong Yi, Luwen Huang, Wei Peng, Ting Zhang, Dong Zhou, Xiaohui Lai, Jinmei Li   +6 more
wiley   +1 more source

Exploration of the Isosteric Concept Applied to 1,2,4-Benzothiadiazine 1,1-Dioxides in the Discovery of Novel AMPA Receptor Positive Allosteric Modulators. [PDF]

ACS Omega
Colson T, Lesenfants C, Goffin E, Fraikin P, Schmitz A, de Tullio P, Danober L, Pirotte B, Francotte P.   +8 more
europepmc   +1 more source

Delayed treatment with YM872, a novel AMPA receptor antagonist, reduces ischemic damage in rats with transient middle cerebral artery occlusions.

, 1999
Chikako Ichiki, Sachiko Kawasaki‐Yatsugi, Shin‐ichi Yatsugi, Tokio Yamaguchi   +3 more
openalex   +1 more source

Activity-Dependent Patterning of Retinogeniculate Axons Proceeds with a Constant Contribution from AMPA and NMDA Receptors [PDF]

, 2000
Carsten D. Hohnke, Serkan Oray, Mriganka Sur   +2 more
openalex   +1 more source

Advances in gene therapy for Lafora disease: Intravenous recombinant adeno‐associated virus‐mediated delivery of EPM2A and EPM2B genes

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Intravenous gene therapy with rAAV2/9P31 vectors delivering EPM2A or EPM2B reversed Lafora disease pathology and restored neuronal function in two mouse models. The approach showed comparable or superior efficacy to intracerebroventricular delivery, with no long‐term toxicity, supporting its translational potential.
Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Miriam Sciaccaluga, Laura Bellingacci, Jacopo Canonichesi, Gema Sánchez‐Martín, Cinzia Costa, Marina P. Sánchez, José M. Serratosa   +8 more
wiley   +1 more source