Results 11 to 20 of about 2,293,512 (363)
AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking [PDF]
Cellular and Molecular Life Sciences, 2019 To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated.
Diane Bissen, F. Foss, A. Acker-Palmer
semanticscholar +5 more sources
Uncorking AMPA receptors [PDF]
Journal of General Physiology, 2018 New JGP study explains how auxiliary proteins relieve polyamine block of AMPARs.
Caitlin Sedwick
semanticscholar +3 more sources
Clathrin-Independent Trafficking of AMPA Receptors [PDF]
The Journal of Neuroscience, 2015 Membrane trafficking of AMPA receptors (AMPARs) is critical for neuronal function and plasticity. Although rapid forms of AMPAR internalization during long-term depression (LTD) require clathrin and dynamin, the mechanisms governing constitutive AMPAR ...
O. Glebov +3 more
semanticscholar +5 more sources
Regulation of AMPA receptors in spinal nociception [PDF]
Molecular Pain, 2010 The functional properties of α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptors in different brain regions, such as hippocampus and cerebellum, have been well studied in vitro and in vivo. The AMPA receptors present a unique characteristic
Lin Qing +5 more
doaj +3 more sources
RNA aptamers for AMPA receptors. [PDF]
Neuropharmacology, 2021 RNA aptamers are single-stranded RNA molecules, and they are selected against a target of interest so that they can bind to and modulate the activity of the target, such as inhibiting the target activity, with high potency and selectivity. Antagonists, such as RNA aptamers, acting on AMPA receptors, a major subtype of ionotropic glutamate receptors ...
Huang Z, Niu L.
europepmc +4 more sources
Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Shaikh, Sana A. +7 more
openaire +5 more sources
Nomadic AMPA Receptors and LTP [PDF]
Neuron, 1999 What are the broader implications of these two reports? One feature of LTP is its reversibility: once established, application of low-frequency stimulus train can decrease the synaptic strength. When applied to naive synapyses (i.e., in fresh brain slices), such low frequency stimulation induces a long-lasting depression of synaptic responses known as ...
Miguel Morales, Yukiko Goda
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AMPA Receptors Bring On the Pain [PDF]
Neuron, 2004 The role of Ca(2+)-permeable AMPA receptors in pain processing has not been extensively studied. In this issue of Neuron, Hartmann et al. show that altering the levels of these receptors has consequences for inflammatory pain hypersensitivity but not acute pain processing.
Amy B. MacDermott, Carole Torsney
openaire +3 more sources
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca +4 more
wiley +1 more source
Sequential Activation of AMPA Receptors and Glial Cells in a Pain Model of Lumbar Spine Disc Herniation [PDF]
Annals of Rehabilitation Medicine, 2020 Objective To investigate the glial cell and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activity after surgery for disc herniation pain model.
Dong Gyu Kwak, Dong Gyu Lee
doaj +1 more source