Results 21 to 30 of about 2,293,512 (363)

Allosteric competition and inhibition in AMPA receptors. [PDF]

Nat Struct Mol Biol, 2023
AbstractExcitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through unresolved ...
Hale WD, Montaño Romero A, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC.   +6 more
europepmc   +4 more sources

Presynaptic AMPA Receptors in Health and Disease. [PDF]

Cells, 2021
AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic plasma membranes. A huge number of studies investigated the role of postsynaptic AMPARs in the normal and abnormal functioning of the mammalian central nervous system (CNS).
Zanetti L, Regoni M, Ratti E, Valtorta F, Sassone J.   +4 more
europepmc   +6 more sources

Activation of acid‐sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation

Molecular Brain, 2021
Reconsolidation has been considered a process in which a consolidated memory is turned into a labile stage. Within the reconsolidation window, the labile memory can be either erased or strengthened.
Boren Lin, Khaled Alganem, Sinead M. O’Donovan, Zhen Jin, FarzanehSadat Naghavi, Olivia A. Miller, Tyler C. Ortyl, Ye Chun Ruan, Robert E. McCullumsmith, Jianyang Du   +9 more
doaj   +1 more source

Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus

Journal of Comparative Neurology, Volume 531, Issue 2, Page 281-293, February 2023., 2023
Hippocampal granule cells of adult mice lacking canonical TNF‐Rs were filled with Alexa568 and immunolabeled for Synaptopodin. Morphometric analysis of their spines revealed that TNF‐R mutants partially replicate changes previously reported for TNF‐deficient mice.
Dinko Smilovic, Michael Rietsche, Meike Fellenz, Alexander Drakew, Mario Vuksic, Thomas Deller   +5 more
wiley   +1 more source

Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew

Journal of Comparative Neurology, Volume 531, Issue 3, Page 390-414, February 2023., 2023
The present work provides a quantitative dataset of synapses from the Etruscan shrew (the smallest known terrestrial mammal). We have identified common and differing principles of synaptic organization compared to other mammalian species. Abstract The main aim of the present study was to determine if synapses from the exceptionally small brain of the ...
Lidia Alonso‐Nanclares, J. Rodrigo Rodríguez, Angel Merchan‐Perez, Juncal González‐Soriano, Sergio Plaza‐Alonso, Nicolás Cano‐Astorga, Robert K. Naumann, Michael Brecht, Javier DeFelipe   +8 more
wiley   +1 more source

AMPA receptor trafficking and learning [PDF]

European Journal of Neuroscience, 2010
AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
Zhaoqing Zheng, Joyce Keifer
openaire   +3 more sources

AMPA Receptor Function in Hypothalamic Synapses [PDF]

Frontiers in Synaptic Neuroscience, 2022
AMPA receptors (AMPARs) are critical for mediating glutamatergic synaptic transmission and plasticity, thus playing a major role in the molecular machinery underlying cellular substrates of memory and learning. Their expression pattern, transport and regulatory mechanisms have been extensively studied in the hippocampus, but their functional properties
Maria Royo, Beatriz Aznar Escolano, M. Pilar Madrigal, Sandra Jurado   +3 more
openaire   +5 more sources

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Science, 2019
Diversity in ion channel complexes AMPA receptors are glutamate activated ion channels that mediate fast synaptic transmission in the nervous system and play a key role in learning and memory.
Yan Zhao, Shanshuang Chen, Adam C. Swensen, W. Qian, E. Gouaux   +4 more
semanticscholar   +1 more source

Gating Modes in AMPA Receptors [PDF]

The Journal of Neuroscience, 2010
AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and
Lonnie P. Wollmuth, Martin Loynaz Prieto
openaire   +3 more sources

AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells

Frontiers in Cellular Neuroscience, 2019
Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
doaj   +1 more source