Results 21 to 30 of about 2,315,831 (319)

Allosteric competition and inhibition in AMPA receptors. [PDF]

Nat Struct Mol Biol, 2023
AbstractExcitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through unresolved ...
Hale WD, Montaño Romero A, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC.   +6 more
europepmc   +4 more sources

Gating Modes in AMPA Receptors [PDF]

The Journal of Neuroscience, 2010
AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and
Lonnie P. Wollmuth, Martin Loynaz Prieto
openaire   +3 more sources

Presynaptic AMPA Receptors in Health and Disease. [PDF]

Cells, 2021
AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic plasma membranes. A huge number of studies investigated the role of postsynaptic AMPARs in the normal and abnormal functioning of the mammalian central nervous system (CNS).
Zanetti L, Regoni M, Ratti E, Valtorta F, Sassone J.   +4 more
europepmc   +6 more sources

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Science, 2019
Diversity in ion channel complexes AMPA receptors are glutamate activated ion channels that mediate fast synaptic transmission in the nervous system and play a key role in learning and memory.
Yan Zhao, Shanshuang Chen, Adam C. Swensen, W. Qian, E. Gouaux   +4 more
semanticscholar   +1 more source

AMPA receptor trafficking and learning [PDF]

European Journal of Neuroscience, 2010
AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
Zhaoqing Zheng, Joyce Keifer
openaire   +3 more sources

AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells

Frontiers in Cellular Neuroscience, 2019
Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
doaj   +1 more source

LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory

Brain : a journal of neurology, 2018
Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), which interacts with voltage-gated ...
Mar Petit-Pedrol, Josefine Sell, J. Planagumà, F. Mannara, Marija Radosevic, H. Haselmann, M. Ceanga, L. Sabater, M. Spatola, David Soto, X. Gasull, J. Dalmau, C. Geis   +12 more
semanticscholar   +1 more source

p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

Nature Communications, 2019
AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jürgen Kast, Jie Lu, Yu Tian Wang   +10 more
doaj   +1 more source

GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice

Frontiers in Molecular Neuroscience, 2012
The GluA2 subunit in heteromeric AMPA receptor channels restricts Ca2+ permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels.
Andrei eRozov, Rolf eSprengel, Peter H Seeburg   +2 more
doaj   +1 more source

Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

Nature, 2017
Long-term potentiation (LTP) of excitatory synaptic transmission has long been considered a cellular correlate for learning and memory. Early LTP (less than 1 h) had initially been explained either by presynaptic increases in glutamate release or by ...
A. Penn, A. Penn, A. Penn, Chun-Lei Zhang, Chun-Lei Zhang, F. Georges, F. Georges, L. Royer, L. Royer, L. Royer, C. Breillat, C. Breillat, E. Hosy, E. Hosy, J. Petersen, J. Petersen, Y. Humeau, Y. Humeau, D. Choquet, D. Choquet   +19 more
semanticscholar   +1 more source