Results 31 to 40 of about 2,293,512 (363)
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory
Brain : a journal of neurology, 2018 Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), which interacts with voltage-gated ...
Mar Petit-Pedrol +12 more
semanticscholar +1 more source
Resensitizing AMPA receptors [PDF]
Journal of General Physiology, 2019 JGP study suggests how the regulatory protein γ8 reopens AMPA receptor channels in the continued presence of glutamate.
openaire +2 more sources
p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
Nature Communications, 2019 AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge +10 more
doaj +1 more source
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors
Nature, 2017 Long-term potentiation (LTP) of excitatory synaptic transmission has long been considered a cellular correlate for learning and memory. Early LTP (less than 1 h) had initially been explained either by presynaptic increases in glutamate release or by ...
A. Penn +19 more
semanticscholar +1 more source
Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
Biomolecules, 2020 It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA ...
Takahisa Hanada
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes, namely, α-amino-3-hydroxy-5-methyl ...
Marina N. Vukolova +5 more
doaj +1 more source
Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]
Physical Review E 82, 041902 (2010), 2010 The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv +1 more source
Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 421-429, December 2022., 2022 Abstract Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the glutamatergic system.
Ahmad Shamabadi
wiley +1 more source
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics
Nature Communications, 2023 AMPA receptors associated with TARP subunits enable the development of selective AMPA receptor drugs. Here, the authors provide cryo-EM structures of receptors bound to three TARP-γ8 selective drugs, and reveal bifunctionality of one ligand.
Danyang Zhang +7 more
doaj +1 more source