Results 31 to 40 of about 2,326,770 (324)

Resensitizing AMPA receptors [PDF]

Journal of General Physiology, 2019
JGP study suggests how the regulatory protein γ8 reopens AMPA receptor channels in the continued presence of glutamate.
openaire   +2 more sources

Presynaptic AMPA Receptors in Health and Disease. [PDF]

Cells, 2021
AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic plasma membranes. A huge number of studies investigated the role of postsynaptic AMPARs in the normal and abnormal functioning of the mammalian central nervous system (CNS).
Zanetti L, Regoni M, Ratti E, Valtorta F, Sassone J.   +4 more
europepmc   +6 more sources

p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

Nature Communications, 2019
AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jürgen Kast, Jie Lu, Yu Tian Wang   +10 more
doaj   +1 more source

GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice

Frontiers in Molecular Neuroscience, 2012
The GluA2 subunit in heteromeric AMPA receptor channels restricts Ca2+ permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels.
Andrei eRozov, Rolf eSprengel, Peter H Seeburg   +2 more
doaj   +1 more source

Allosteric competition and inhibition in AMPA receptors. [PDF]

Nat Struct Mol Biol, 2023
AbstractExcitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through unresolved ...
Hale WD, Montaño Romero A, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC.   +6 more
europepmc   +4 more sources

Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

Nature, 2017
Long-term potentiation (LTP) of excitatory synaptic transmission has long been considered a cellular correlate for learning and memory. Early LTP (less than 1 h) had initially been explained either by presynaptic increases in glutamate release or by ...
A. Penn, A. Penn, A. Penn, Chun-Lei Zhang, Chun-Lei Zhang, F. Georges, F. Georges, L. Royer, L. Royer, L. Royer, C. Breillat, C. Breillat, E. Hosy, E. Hosy, J. Petersen, J. Petersen, Y. Humeau, Y. Humeau, D. Choquet, D. Choquet   +19 more
semanticscholar   +1 more source

AMPA Receptor Function in Hypothalamic Synapses [PDF]

Frontiers in Synaptic Neuroscience, 2022
AMPA receptors (AMPARs) are critical for mediating glutamatergic synaptic transmission and plasticity, thus playing a major role in the molecular machinery underlying cellular substrates of memory and learning. Their expression pattern, transport and regulatory mechanisms have been extensively studied in the hippocampus, but their functional properties
Royo, María, Aznar Escolano, Beatriz, Madrigal, M. Pilar, Jurado, Sandra   +3 more
openaire   +5 more sources

Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum

Neuroscience, 2009
Heterogeneity among AMPA receptor (AMPAR) subtypes is thought to be one of the key postsynaptic factors giving rise to diversity in excitatory synaptic signaling in the CNS. Recently, compelling evidence has emerged that ancillary AMPAR subunits-the so-called transmembrane AMPA receptor regulatory proteins (TARPs)-also play a vital role in influencing ...
Ian D. Coombs, Stuart G. Cull-Candy
openaire   +3 more sources

P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals

The Journal of Headache and Pain, 2020
Background Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA receptors thus inducing Glu release from ...
Diego Currò, Pierluigi Navarra, Irene Samengo, Maria Martire   +3 more
doaj   +1 more source

Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics

Nature Communications, 2023
AMPA receptors associated with TARP subunits enable the development of selective AMPA receptor drugs. Here, the authors provide cryo-EM structures of receptors bound to three TARP-γ8 selective drugs, and reveal bifunctionality of one ligand.
Danyang Zhang, Remigijus Lape, Saher A. Shaikh, Bianka K. Kohegyi, Jake F. Watson, Ondrej Cais, Terunaga Nakagawa, Ingo H. Greger   +7 more
doaj   +1 more source