Results 31 to 40 of about 381,413 (281)

Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties

, 2022
We report the synthesis and antibacterial activities of a series of amphiphilic membrane-active peptides composed, in part, of various nongenetically coded hydrophobic amino acids.
Wonsuk Choi (5859692), Roman G. Efremov (222432), Sandeep Lohan (11184726), Rakesh K. Tiwari (1337817), Anastasia G. Konshina (9931604), Keykavous Parang (281303), Dindyal Mandal (1929907), Innokentiy Maslennikov (85338)   +7 more
core   +2 more sources

Amphiphilic Cell-Penetrating Peptides Containing Arginine and Hydrophobic Residues as Protein Delivery Agents

Pharmaceuticals, 2023
The entry of proteins through the cell membrane is challenging, thus limiting their use as potential therapeutics. Seven cell-penetrating peptides, designed in our laboratory, were evaluated for the delivery of proteins.
Jonathan Moreno, Khalid Zoghebi, David Salehi, Lois Kim, Sorour Khayyatnejad Shoushtari, Rakesh K. Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine [PDF]

, 2012
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Schöllmann, C., Korting, Hans Christian, Schäfer-Korting, Monika, Stauss-Grabo, M.   +3 more
core   +1 more source

Fibrils from designed non-amyloid-related synthetic peptides induce AA-amyloidosis during inflammation in an animal model. [PDF]

PLoS ONE, 2009
BACKGROUND:Mouse AA-amyloidosis is a transmissible disease by a prion-like mechanism where amyloid fibrils act by seeding. Synthetic peptides with no amyloid relationship can assemble into amyloid-like fibrils and these may have seeding capacity for ...
Per Westermark, Katarzyna Lundmark, Gunilla T Westermark   +2 more
doaj   +1 more source

Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8: Effect of Molecular Hydrophobicity, Charge Number and Charge Location

Nanomaterials, 2021
Three amphiphilic peptides with varied molecular hydrophobicity, charge number and charge location have been designed as regulators to modulate the crystal growth of zeolitic imidazolate framework-8 (ZIF-8).
Maozhang Tian, Xi Chen, Qun Zhang, Xinyuan Zou, Desheng Ma, Jiaming Xuan, Wentao Wang, Meiwen Cao   +7 more
doaj   +1 more source

Conversion of cationic amphiphilic lytic peptides to cell‐penetration peptides

, 2020
Accomplishment of efficient intracellular delivery of bioactive peptides and proteins have been reported via conjugation of peptides having membrane permeation ability (i.e., cell-penetrating peptides [CPPs]), where a physiological uptake system of ...
Ikuhiko Nakase, Astrid Gräslund, Akishiba, Misao, Sakamoto, Kentarou, Misao Akishiba, Gräslund, Astrid,, Hao‐Hsin Yu, Shiroh Futaki, Naoki Tamemoto, Miki Imanishi, Tamemoto, Naoki, Kentarou Sakamoto, Imanishi, Miki, Madani, Fatemeh,, Hirose, Hisaaki, Yu, Hao-Hsin, Futaki, Shiroh, Fatemeh Madani, Nakase, Ikuhiko, Hisaaki Hirose   +19 more
core   +1 more source

Mimicking charged host-defence peptides to tune antifungal activity and biocompatibility of amphiphilic polymers [PDF]

, 2023
Invasive fungal infections impose a substantial global health burden. They cause more than 1.5 million deaths annually and are insufficiently met by the currently approved antifungal drugs.
Megan, Lenardon, Daniele, Melodia, Cyrille, Boyer, Nathaniel, Corrigan, Sebastian, Schaefer   +4 more
core   +2 more sources

Synthesis of a Peptide Emulsifier with an Amphiphilic Structure

Bioscience, Biotechnology, and Biochemistry, 1995
Three kinds of peptides (H, S, and R) with 16 amino acid residues were synthesized, and their secondary structure and emulsifying properties (emulsifying activity and oil-binding property) were investigated to clarify the effects of conformational amphiphilicity. The amino acid compositions of the three peptides were the same (8 Leu and 8 Glu residues)
Saito, Masayoshi, Masashi, Ogasawara, Koichi, Chikuni, Makoto, Shimizu   +3 more
openaire   +2 more sources

Designer amphiphilic short peptides enhance thermal stability of isolated photosystem-I. [PDF]

PLoS ONE, 2010
Stability of membrane protein is crucial during protein purification and crystallization as well as in the fabrication of protein-based devices. Several recent studies have examined how various surfactants can stabilize membrane proteins out of their ...
Baosheng Ge, Feng Yang, Daoyong Yu, Shuang Liu, Hai Xu   +4 more
doaj   +1 more source

Amphiphilic Triazolyl Peptides: Synthesis and Evaluation as Nanostructures [PDF]

, 2014
A new class of amphiphilic triazolyl peptides was designed and synthesized from peptide-based building blocks containing alkyne and azide functional groups namely linear (W(pG))3, cyclic[W(pG)]3, and Ac-K(N3)R-NH2,where W, R, K, and pG represent ...
Sun, Jiadong, Banerjee, Antara, Parang, Keykavous, Oh, Donghoon, Rowley, David, Sayeh, Naser, Shirazi, Amir Nasrolahi, Yadav, Arpita, Tiwari, Rakesh   +8 more
core   +1 more source