Results 41 to 50 of about 381,413 (281)

Hydration Dynamics of Model Peptides with Different Hydrophobic Character

Life, 2022
The multi-scale dynamics of aqueous solutions of the hydrophilic peptide N-acetyl-glycine-methylamide (NAGMA) have been investigated through extended frequency-range depolarized light scattering (EDLS), which enables the broad-band detection of ...
Laura Lupi, Brenda Bracco, Paola Sassi, Silvia Corezzi, Assunta Morresi, Daniele Fioretto, Lucia Comez, Marco Paolantoni   +7 more
doaj   +1 more source

Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite

Gels, 2019
Amphiphilic peptides can be self-assembled by establishing physical cross-links involving hydrogen bonds and electrostatic interactions with divalent ions.
Manuel Rivas, Luís J. del Valle, Carlos Alemán, Jordi Puiggalí   +3 more
doaj   +1 more source

Recent Advances and Challenges in Nanodelivery Systems for Antimicrobial Peptides (AMPs)

Antibiotics, 2021
Antimicrobial peptides (AMPs) can be used as alternative therapeutic agents to traditional antibiotics. These peptides have abundant natural template sources and can be isolated from animals, plants, and microorganisms.
Ziyan Tang, Quantao Ma, Xiaoling Chen, Tianbao Chen, Yuan Ying, Xinping Xi, Lei Wang, Chengbang Ma, Chris Shaw, Mei Zhou   +9 more
doaj   +1 more source

Enhanced salt-tolerance of Bacillus subtilis glutaminase by fusing self-assembling amphipathic peptides at its N-terminus

Frontiers in Bioengineering and Biotechnology, 2022
Glutaminase (EC 3.5.1.2) can catalyze the deamidation of glutamine, which has been used to improve umami taste in oriental fermented foods. However, a high salt concentration is still a fundamental challenge for glutaminase application, especially in soy
Song Liu, Song Liu, Song Liu, Shengqi Rao, Xiao Chen, Xiao Chen, Jianghua Li, Jianghua Li   +7 more
doaj   +1 more source

Peptide Amphiphiles for Pharmaceutical Applications

Current Medicinal Chemistry
Abstract: During the last few decades, several efforts have been made towards developing biocompatible materials. Among them, peptide amphiphiles (PAs) constitute a novel nanotechnological strategy used in the field of biomedicine since they can provide tissue- specific binding and localization.
Mayra Alejandra Fuertes-Llanos, Maria José Gómara, Isabel Haro, Elena Sánchez-López   +3 more
openaire   +3 more sources

Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles [PDF]

, 2015
Intrinsically disordered proteins/peptides play a crucial role in many physiological and pathological events and may assume a precise conformation upon binding to a specific target.
Portella, L., Susan Costantini, Accardo, A., Scala, S., Ronga, Luisa, Luisa Ronga, Annamaria Trotta, Stefania Scala, ROSSI, FILOMENA, Marilisa Leone, Giovanni Colonna, Guillon, J., Luigi Portella, Colonna, G., Jean Guillon, Costantini, S., Trotta, A., Leone, M., Tesauro, D., TESAURO, DIEGO, ACCARDO, ANTONELLA, Vincenzi, M., VINCENZI, MARIAN, Rossi, F.   +23 more
core   +1 more source

Water ordering controls the dynamic equilibrium of micelle–fibre formation in self-assembly of peptide amphiphiles

Nature Communications, 2016
The role of water in the kinetics of the self-assembly process of amphiphilic peptides still remains unknown. Sankaranarayanan et al. have shown through computational study that water has a dual nature when dictating the mechanism and dynamics of self ...
Sanket A. Deshmukh, Lee A. Solomon, Ganesh Kamath, H. Christopher Fry, Subramanian K. R. S. Sankaranarayanan   +4 more
doaj   +1 more source

Computational Amphiphilic Materials for Drug Delivery

Frontiers in Materials, 2015
Amphiphilic materials can assemble into a wide variety of morphologies and have emerged as a novel class of candidates for drug delivery. Along with a large number of experiments reported, computational studies have been also conducted in this field.
Naresh eThota, Jianwen eJiang
doaj   +1 more source

Novel pH Selective, Highly Lytic Peptides Based on a Chimeric Influenza Hemagglutinin Peptide/Cell Penetrating Peptide Motif

Molecules, 2019
Delivery of macromolecular cargos such as siRNA to the cytosol after endocytosis remains a critical challenge. Numerous approaches including viruses, lipid nanoparticles, polymeric constructs, and various peptide-based approaches have yet to yield a ...
Bethany Algayer, Ann O’Brien, Aaron Momose, Dennis J. Murphy, William Procopio, David M. Tellers, Thomas J. Tucker   +6 more
doaj   +1 more source

Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides

Molecules, 2021
Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects.
Filippo Prencipe, Carlo Diaferia, Filomena Rossi, Luisa Ronga, Diego Tesauro   +4 more
doaj   +1 more source