Results 61 to 70 of about 381,413 (281)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Self‐Assembled Crystalline Peptoid Nanomaterials as Metal‐Free Enzyme Mimics for Enhanced Carbon Dioxide Hydration and Precipitation

Advanced Functional Materials, EarlyView.
Inspired by metal‐free carbonic anhydrases (CAs) that achieve efficient catalysis without metal cofactors, we herein report a sequence‐defined supramolecular peptoid platform that mimics metal‐free CAs and exhibits hydrolytic activity via a supramolecular assembly‐mediated proton‐transfer mechanism.
Progyateg Chakma, Ying Chen, Thi Kim Hoang Trinh, Anthony R. Perez, Jonathan Gil, Maria Casco Hidalgo, Botao Hao, Kyle Whitaker, Chun‐Long Chen   +8 more
wiley   +1 more source

Elasticity of Lipid Bilayer Interacting with Amphiphilic Helical Peptides

, 1995
Amphiphilic helical peptides exhibit an insertion transition when they interact with lipid bilayers. At low concentrations, the peptides adsorb at the hydrophilic-hydrophobic interface with the helical axes parallel to the bilayer surface.
Huey W. Huang
core   +1 more source

The Effect of Hydrophilic Headgroup Chemistry on Peptoid‐Directed Mineralization of CaCO3

Advanced Functional Materials, EarlyView.
Amphiphilic peptoids alter the pathway and outcome of calcium carbonate crystallization, which progresses through amorphous calcium carbonate (ACC) to vaterite to calcite rhombs in the absence of peptoids. In contrast, amine‐terminated peptoids produce vaterite disks and carboxyl‐terminated peptoids produce calcite mesocrystals.
Biao Jin, Chunhui Wu, Thi Kim Hoang Trinh, Wenhao Zhou, Chun‐Long Chen, James J De Yoreo   +5 more
wiley   +1 more source

Tipping the Scale from Disorder to Alpha-helix: Folding of Amphiphilic Peptides in the Presence of Macroscopic and Molecular Interfaces. [PDF]

PLoS Computational Biology, 2015
Secondary amphiphilicity is inherent to the secondary structural elements of proteins. By forming energetically favorable contacts with each other these amphiphilic building blocks give rise to the formation of a tertiary structure.
Cahit Dalgicdir, Christoph Globisch, Christine Peter, Mehmet Sayar   +3 more
doaj   +1 more source

Overlapping Properties of the Short Membrane-Active Peptide BP100 With (i) Polycationic TAT and (ii) α-helical Magainin Family Peptides

Frontiers in Cellular and Infection Microbiology, 2021
BP100 is a short, designer-made membrane-active peptide with multiple functionalities: antimicrobial, cell-penetrating, and fusogenic. Consisting of five lysines and 6 hydrophobic residues, BP100 was shown to bind to lipid bilayers as an amphipathic α ...
Christian Mink, Erik Strandberg, Parvesh Wadhwani, Manuel N. Melo, Johannes Reichert, Irene Wacker, Miguel A. R. B. Castanho, Anne S. Ulrich, Anne S. Ulrich   +8 more
doaj   +1 more source

Interaction between amphiphilic peptides and phospholipid membranes [PDF]

, 2010
This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane ...
Stromstedt, Adam A., Ringstad, Lovisa, Malmsten, Martin, Schmidtchen, Artur,, Schmidtchen, Artur, Malmsten, Martin,, Lund University., Ringstad, Lovisa,, Strömstedt, Adam A.,   +8 more
core   +1 more source

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

Advanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa, Pablo Martínez‐Vicente, Lucía G. Recaredo, Susel Del Sol‐Fernández, Pilar Gomollón‐Zueco, Yilian Fernández‐Afonso, Raluca M. Fratila, María Moros   +7 more
wiley   +1 more source

In Situ Interfacial Assembly of Dynamic Semi‐Interpenetrating Biopolymer Networks for Robust and Mechanically Adaptive Droplet Interfaces

Advanced Functional Materials, EarlyView.
A dynamic interfacial semi‐interpenetrating polymer network is constructed by sequential assembly of β‐sheet‐rich SF and CS‐RL. The SF framework provides mechanical strength, while dynamically associated CS‐RL enables local rearrangement, allowing droplets to rapidly reconfigure without loss of interfacial integrity.
Yaping Zhang, Yujie Liu, Yikai Xu, Xunda Feng, Ling Zhang, Hongbo Zeng, Hao Liu, Xiaohui Mao   +7 more
wiley   +1 more source

p‐Sulfonatocalix[4]arene‐Based Ratiometric Fluorescence Chemosensor Array for the Differential Detection of Polycationic Peptides

ChemistryEurope
Arginine‐rich peptides and arginine‐rich motifs in proteins are important sensing targets owing to their critical role in several biological processes.
Joana N. Martins, Márcia Pessêgo, Lucia Méndez‐Gómez, Hanieh Mahmoodi, Javier Montenegro, Luis Garcia‐Rio, João Carlos Lima, Nuno Basílio   +7 more
doaj   +1 more source