Results 141 to 150 of about 112,937 (259)

The TWEAK-HOIP-HuR Axis: A Novel Mechanism of AMPK Inactivation and Metabolic Reprogramming in Lupus Nephritis Mesangial Cells Hyperproliferation. [PDF]

Mediators Inflamm
Ding Z, Liu E, Li X, Zhang Y, Li L, Weng C, Liu Z, Liu Z.   +7 more
europepmc   +1 more source

Progress on the Protective Effect and the Mechanism of Chinese Medicine Injection and Chinese Medicine Monomeric Small Molecules on Sepsis‐Related Liver Injury

Gut Medicine, EarlyView.
ABSTRACT Sepsis‐related liver injury (SRLI) involves multiple interrelated pathological processes, including excessive inflammation, oxidative imbalance, mitochondrial dysfunction, dysregulated autophagy, and microcirculatory impairment. Increasing evidence indicates that traditional Chinese medicine (TCM)–based interventions, particularly Chinese ...
Xiang Yunsheng, Yan Yumeng
wiley   +1 more source

Metabolic orchestration of NOD1 signaling by AMPK-mediated phosphorylation of ZDHHC5. [PDF]

iScience
Mi S, Zhu Y, Li Q, Zhang W, Pei H, Yao F, Guo X, Chen Y.   +7 more
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Axonal protection by nicotinamide riboside with the SIRT1-AMPK pathway in TNF-induced optic nerve damage. [PDF]

Mol Biol Rep
Kitaoka Y, Tsukahara C, Fujita N, Arizono I, Otsubo M, Sase K.   +5 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage. [PDF]

Biology (Basel)
Bai S, La X, Yang Y, Li Y, Wang D, Ren Y, Fang H, Li X, Song X, Cheng X, Xu D.   +10 more
europepmc   +1 more source

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, EarlyView.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Phosphoenolpyruvate carboxykinase 2 activation of the AMPK-CEBPB axis to enhance glutamine utilization to promote glycolysis and malignant behavior in adenocarcinomas cells under glucose deprivation. [PDF]

J Cell Commun Signal
Ruan L, Xu K, Zeng W, Xiao L, Zhao M, Zhang H.   +5 more
europepmc   +1 more source