Results 151 to 160 of about 228,730 (331)

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

AMPK activators: mechanisms of action and physiological activities

Experimental and Molecular Medicine, 2016
AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. Because of the favorable physiological outcomes of AMPK activation on metabolism,
Joungmok Kim, Goowon Yang, Yeji Kim, Jin Kim, J. Ha   +4 more
semanticscholar   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems

Biomolecules, 2019
Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate ...
Shima Tavakol, Milad Ashrafizadeh, Shuo Deng, Maryam Azarian, Asghar Abdoli, Mahsa Motavaf, Delaram Poormoghadam, Hashem Khanbabaei, Elham Ghasemipour Afshar, Ali Mandegary, Abbas Pardakhty, Celestial T. Yap, Reza Mohammadinejad, Alan Prem Kumar   +13 more
doaj   +1 more source

AMPK directly activates mTORC2 to promote cell survival during acute energetic stress

Science Signaling, 2019
AMPK ensures cell survival during energetic stress by stimulating the kinase Akt through mTORC2. Surviving energetic stress with mTORC2 The roles and regulation of mTORC2, a multiprotein complex that contains the kinase mTOR in association with rictor ...
D. Kazyken, Brian Magnuson, C. Bodur, Hugo A. Acosta-Jaquez, Deqiang Zhang, X. Tong, Tammy M. Barnes, Gabrielle K. Steinl, Nicole E. Patterson, Christopher H. Altheim, N. Sharma, K. Inoki, G. Cartee, D. Bridges, L. Yin, Steven M. Riddle, D. Fingar   +16 more
semanticscholar   +1 more source

Animal Models to Study AMPK

, 2016
AMPK is an evolutionary conserved energy sensor involved in the regulation of energy metabolism. Based on biochemical studies, AMPK has brought much of interest in recent years due to its potential impact on metabolic disorders. Suitable animal models are therefore essential to promote our understanding of the molecular and functional roles of AMPK but
Viollet, Benoit, Foretz, Marc
openaire   +2 more sources

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

Can we run away from the metabolic side effects of antipsychotics?

Translational Exercise Biomedicine
Antipsychotic (AP) medications are used to treat schizophrenia and a number off-label conditions. Although effective in reducing psychoses these drugs increase the risk of developing cardiometabolic disease, and are one of the reasons why individuals ...
Akcan Michael, Wright David C.
doaj   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis

Drug Design, Development and Therapy
Yidong Cui,1 Qingming Liu,2 Qiqiang Zhang,3 Xuemei Di,3 Hai Zhang3 1Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People’s Republic of China;
Cui Y, Liu Q, Zhang Q, Di X, Zhang H
doaj