Results 31 to 40 of about 228,730 (331)
Mechanotransduction of mitochondrial AMPK and its distinct role in flow-induced breast cancer cell migration [PDF]
, 2019 The biophysical microenvironment of the tumor site has significant impact on breast cancer progression and metastasis. The importance of altered mechanotransduction in cancerous tissue has been documented, yet its role in the regulation of cellular ...
Guo, Yunxia +3 more
core +1 more source
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Journal of Hematology & Oncology, 2020 Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40%
Jimin Yuan +3 more
semanticscholar +1 more source
Journal of Inflammation Research, 2022 Ji Zhu,1,* Hang Chen,2,* Jianan Guo,2 Chen Zha,1 Dezhao Lu2 1The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, People’s Republic of China; 2School of Life Sciences, Zhejiang ...
Zhu J, Chen H, Guo J, Zha C, Lu D
doaj
NF-κB signaling and crosstalk during carcinogenesis
4 open, 2019 Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M. +2 more
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Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells [PDF]
, 2014 The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1),
Chen +53 more
core +4 more sources
Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]
, 2014 The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
AN Macintyre +29 more
core +4 more sources
The Role of AMPK Signaling in Ulcerative Colitis
Drug Design, Development and Therapy, 2023 Yuyi Yuan,1,* Fang Wang,2,* Xingxing Liu,1,* Bo Shuai,1 Heng Fan1 1Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022,
Yuan Y, Wang F, Liu X, Shuai B, Fan H
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Calcium signalling links MYC to NUAK1 [PDF]
, 2018 NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A, +5 more
core +1 more source
STIM2 interacts with AMPK and regulates calcium‐induced AMPK activation [PDF]
The FASEB Journal, 2018 ABSTRACT AMPK is a crucial regulator of energy homeostasis that acts downstream of its upstream kinase liver kinase B1 (LKB1) and calcium/calmodulin‐dependent protein kinase 2 (CaMKK2). LKB1 primarily phosphorylates AMPK after energy stress, whereas calcium‐mediated activation of AMPK requires CaMKK2, although the
Chauhan, Anoop Singh +7 more
openaire +2 more sources
Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
Pharmaceutical Biology, 2019 Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications. Objective: To investigate the effect of curcumin on gestational diabetes (GD).
Xuehong Lu +4 more
doaj +1 more source