Results 1 to 10 of about 1,170 (185)

Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate [PDF]

Frontiers in Physiology, 2022
Introduction: Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiovascular dysfunction, which could lead to shock. Current guidelines do not recommend any pharmacological treatment at core temperatures below 30°C, due ...
Adrina Kalasho Kuzmiszyn, Adrina Kalasho Kuzmiszyn, Adrina Kalasho Kuzmiszyn, Anders Lund Selli, Natalia Smaglyukova, Timofei Kondratiev, Ole-Martin Fuskevåg, Roy Andre Lyså, Aina Westrheim Ravna, Torkjel Tveita, Torkjel Tveita, Georg Sager, Erik Sveberg Dietrichs, Erik Sveberg Dietrichs   +13 more
doaj   +2 more sources

The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy [PDF]

Frontiers in Nutrition, 2021
Anaerobic glycolysis is the process by which glucose is broken down into pyruvate and lactate and is the primary metabolic pathway in sepsis. The pyruvate dehydrogenase complex (PDHC) is a multienzyme complex that serves as a critical hub in energy ...
Zhenhua Zeng, Qiaobing Huang, Liangfeng Mao, Jie Wu, Sheng An, Zhongqing Chen, Weijin Zhang   +6 more
doaj   +2 more sources

Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization [PDF]

Brazilian Journal of Medical and Biological Research, 2004
Hemodynamic care during postoperative management of myocardial revascularization should include vasorelaxing drugs to insure adequate graft and coronary flow, and stimulation of stroke volume to maintain vascular perfusion pressure. We tested the cardiac
A. Gómez-Alvis, A. Rebolledo, V. Milesi, J. Raingo, N. Sanz, J. Tommasi, A. Drago, G. Rinaldi, A. Grassi   +8 more
doaj   +3 more sources

Effect of amrinone on myocardial mitochondria function

FEBS Letters, 1988
The effect of amrinone on cardiac mitochondria of guinea pig was studied. It was found that amrinone does not change the respiratory function of cardiac mitochondria in the presence of alpha-ketoglutarate, whereas it inhibits glutamate oxidation.
Cristina Mussini, U Muscatello
exaly   +3 more sources

Effects of amrinone on bilateral renal ischemia/reperfusion injury

Urological Research, 2002
Renal ischemia/reperfusion injury could arise as a consequence of clinical conditions such as renal transplantation. shock, cardiac arrest. hemorrhage and renal artery surgery. In this experimental study.
K Sönmez
exaly   +2 more sources

The effects of amrinone and glucagon on verapamil‐induced cardiovascular toxicity in anaesthetized rats

International Journal of Experimental Pathology, 1996
The goal of this study was to compare the effects of glucagon and amrinone on mean arterial pressure (MAP) and heart rate, when used alone and in combination, in an anaesthetized rat model of verapamil toxicity.
Yesim Tuncok, Sebnem Apaydin, Sule Kalkan   +2 more
exaly   +2 more sources

Properties and synthesis of milrinone [PDF]

Hemijska Industrija, 2013
Milrinone, 1,6-dihydro-2-methyl-6-oxo-[3,4’-bipyridine]-5-carbonitrile, is a positive inotropic cardiotonic agent with vasodilator properties that acts as selective phosphodiesterase 3 inhibitor in cardiac and vascular smooth muscle.
Mirković Jelena M., Mijin Dušan Ž., Petrović Slobodan D.   +2 more
doaj   +1 more source

Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin [PDF]

, 2009
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force.
Torres, Nuria Albet,, Geeves, M., Barman, T., Barman, Tom, Bloemink, Marieke J, Schmitz, S, Piperio, C., Lionne, C, Albet-Torres, Nuria, Schmitz, Stephan, Bloemink, Marieke J., Golker, K., Bloemink, M., Candau, R., Veigel, C., Herrmann, Christian, Albet-Torres, N., Geeves, Michael A, Mansson, A., Mansson, Alf, Herrmann, C., Månsson, Alf,, Piperio, C, Candau, Robin, Geeves, Michael A., Herrmann, C, Frölander, Kerstin,, Schmitz, S., Candau, R, Piperio, Claudia, Lionne, Corinne, Veigel, Claudia, Bloemink, MJ, Geeves, MA, Frolander, K., Lionne, C., Golker, Kerstin, Frolander, Kerstin, Veigel, C, Golker, Kerstin,, Barman, T   +40 more
core   +1 more source

The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury

BMC Infectious Diseases, 2009
Background Acute kidney injury frequently accompanies sepsis. Endotoxin is known to reduce tissue levels of cAMP and low levels of cAMP have been associated with renal injury.
Seo Jeong Wook, Kwon Kun Young, Choi Won-Il, Beagle John, Quinn Deborah A, Hales Charles A   +5 more
doaj   +1 more source

Effect of phosphodiesterase inhibition with amrinone or theophylline on lipolysis and blood flow in human adipose tissue in vivo as measured with microdialysis

Journal of Lipid Research, 1993
Phosphodiesterase III (cyclic GMP-inhibited, particulate, low Km) is believed to play a dominant role in the cyclic AMP breakdown and lipolysis regulation in fat cells. Its importance for lipolysis activity was investigated in situ in humans by comparing
P Arner, J Hellmér, E Hagström-Toft, J Bolinder   +3 more
doaj   +1 more source