Results 31 to 40 of about 1,296 (182)

The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury

BMC Infectious Diseases, 2009
Background Acute kidney injury frequently accompanies sepsis. Endotoxin is known to reduce tissue levels of cAMP and low levels of cAMP have been associated with renal injury.
Seo Jeong Wook, Kwon Kun Young, Choi Won-Il, Beagle John, Quinn Deborah A, Hales Charles A   +5 more
doaj   +1 more source

Effect of phosphodiesterase inhibition with amrinone or theophylline on lipolysis and blood flow in human adipose tissue in vivo as measured with microdialysis

Journal of Lipid Research, 1993
Phosphodiesterase III (cyclic GMP-inhibited, particulate, low Km) is believed to play a dominant role in the cyclic AMP breakdown and lipolysis regulation in fat cells. Its importance for lipolysis activity was investigated in situ in humans by comparing
P Arner, J Hellmér, E Hagström-Toft, J Bolinder   +3 more
doaj   +1 more source

Comparison of Enoximone, Amrinone, or Levosimendan Enriched St. Thomas’ Hospital Cardioplegic Solutions Used for Myocardial Preservation in Isolated Guinea Pig Hearts

Acta Medica, 2002
Myocardial contractile function after cardioplegic arrest is often depressed and an ideal cardioplegic solution has not been developed yet. The aim of this study was to assess the efficacy of phosphodiesterase III inhibitors, amrinone and enoximone, and ...
Cengiz Köksal, Öner Süzer, A Kürsat Bozkurt, Sebahat Köseoğlu   +3 more
doaj   +1 more source

Vibrational Spectroscopic and Molecular Docking Studies of Amrinone, A Cardiotonic Inotropic Drug

, 2023
Amrinone is a class I cardiotonic inotropic agent, which is known to increase the cyclic adenosine monophosphate (cAMP) level by inhibiting the phosphodiesterase 3 (PDE3) enzyme.
Akalin, Elif, Celik, Sefa, Ozel, Aysen E., AKYÜZ, SEVİM   +3 more
core   +1 more source

Amrinone in the treatment of chronic cardiac failure [PDF]

, 1984
The efficacy and safety of oral amrinone were examined in 17 patients with moderately severe to severe heart failure that was refractory to standard medical therapy and vasodilators.
Andrews, Virginia, Likoff, Mariell J., Janicki, Joseph S., Wilson, Hugh, Rocci, Mario L., John Sutton, Martin St., Weber, Karl T.   +6 more
core   +1 more source

Inhibition and Facilitation by Pimobendan, a Calcium Sensitizer, of Catecholamine Secretion From Bovine Adrenal Chromaffin Cells

Journal of Pharmacological Sciences, 2003
The effects of pimobendan, a Ca2+ sensitizer with inhibitory action against cyclic-GMP-inhibited phosphodiesterase (PDE-III), on catecholamine (CA) secretion were studied in bovine adrenal chromaffin cells.
Haruhiro Kuwashima, Chiaki Matsumura, Tomohiko Kimura   +2 more
doaj   +1 more source

Clinical features, complications, and outcomes of exogenous and endogenous catecholamine‐triggered Takotsubo syndrome: A systematic review and meta‐analysis of 156 published cases

Clinical Cardiology, Volume 43, Issue 5, Page 459-467, May 2020., 2020
Abstract Innumerable physical stress factors including externally administered catecholamines, and pheochromocytomas and paragangliomas (PPGLs) have been reported to trigger Takotsubo syndrome (TS). A systematic search of PubMed/MEDLINE identified 156 patients with catecholamine‐induced TS up to December 2017.
Shams Y‐Hassan, Henrik Falhammar
wiley   +1 more source

Effect of amrinone on diaphragm blood flow

, 1988
The purpose of the present study was to examine the effect of amrinone, a drug known to augment cardiac output and dilate peripheral vascular beds, on diaphragm blood flow.
J. S. Arnold, R. J. Bundy, G. S. Supinski, A. F. DiMarco, F. Hussein   +4 more
core   +1 more source

Beneficial effect of amrinone on murine cardiac allograft survival

, 1995
SUMMARY Amrinone is a non-glycoside positive inotropic agent with an inhibitory effect on a cyclic adenosine monophosphate (AMP) phosphodiesterase isoenzyme. In the present study, we examined the immunosuppressive action of amrinone, since
Y Furukawa, A Matsumori, Y Matoba, Y Sato, S Sasayama, T Hirozane, S Matsui   +6 more
core   +1 more source

Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum

Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016
Leishmaniasis and Chagas disease are neglected parasitic diseases endemic in developing countries; efforts to find new therapies remain a priority. Calcium channel blockers (CCBs) are drugs in clinical use for hypertension and other heart pathologies. Based on previous reports about the antileishmanial activity of dihydropyridine‐CCBs, this work aimed ...
Juliana Quero Reimão, Juliana Tonini Mesquita, Daiane Dias Ferreira, Andre Gustavo Tempone, Juntra Karbwang   +4 more
wiley   +1 more source