Results 21 to 30 of about 1,170 (185)
Clinical Transplantation, Volume 35, Issue 8, August 2021., 2021 Abstract Background Inotrope score has been proposed as a marker of clinical outcome after adult heart transplantation (HTx) but is rarely used in practice. Methods Inotrope score during the first 48 h after HTx was calculated in 81 patients as: dopamine + dobutamine + amrinone + milrinone (dose × 15) + epinephrine (dose × 100) + norepinephrine (dose ×
Constantijn S. Venema +4 more
wiley +1 more source
British Journal of Pharmacology, Volume 178, Issue 5, Page 1095-1113, March 2021., 2021 Background and Purpose Excessive oxidative stress can induce PARP1‐mediated programmed necrotic cell death, termed parthanatos. Inhibition of parthanatos may be therapeutically beneficial in a wide array of diseases associated with tissue injury and inflammation. Our goal was to identify novel molecules inhibiting parthanatos.
Zsolt Regdon +8 more
wiley +1 more source
BioMed Research International, Volume 2021, Issue 1, 2021., 2021 Objective. Epithelial‐mesenchymal transition (EMT) exerts a key function in cancer initiation and progression. Herein, we aimed to develop an EMT‐based prognostic signature in gastric cancer. Methods. The gene expression profiles of gastric cancer were obtained from TCGA dataset as a training set and GSE66229 and GSE84437 datasets as validation sets ...
Huiyong Xu +6 more
wiley +1 more source
Acta Medica, 2002 Myocardial contractile function after cardioplegic arrest is often depressed and an ideal cardioplegic solution has not been developed yet. The aim of this study was to assess the efficacy of phosphodiesterase III inhibitors, amrinone and enoximone, and ...
Cengiz Köksal +3 more
doaj +1 more source
Vibrational Spectroscopic and Molecular Docking Studies of Amrinone, A Cardiotonic Inotropic Drug
, 2023 Amrinone is a class I cardiotonic inotropic agent, which is known to increase the cyclic adenosine monophosphate (cAMP) level by inhibiting the phosphodiesterase 3 (PDE3) enzyme.
Akalin, Elif +3 more
core +1 more source
Clinical Cardiology, Volume 43, Issue 5, Page 459-467, May 2020., 2020 Abstract Innumerable physical stress factors including externally administered catecholamines, and pheochromocytomas and paragangliomas (PPGLs) have been reported to trigger Takotsubo syndrome (TS). A systematic search of PubMed/MEDLINE identified 156 patients with catecholamine‐induced TS up to December 2017.
Shams Y‐Hassan, Henrik Falhammar
wiley +1 more source
Journal of Pharmacological Sciences, 2003 The effects of pimobendan, a Ca2+ sensitizer with inhibitory action against cyclic-GMP-inhibited phosphodiesterase (PDE-III), on catecholamine (CA) secretion were studied in bovine adrenal chromaffin cells.
Haruhiro Kuwashima +2 more
doaj +1 more source
Effect of amrinone on diaphragm blood flow
, 1988 The purpose of the present study was to examine the effect of amrinone, a drug known to augment cardiac output and dilate peripheral vascular beds, on diaphragm blood flow.
J. S. Arnold +4 more
core +1 more source
Beneficial effect of amrinone on murine cardiac allograft survival
, 1995 SUMMARY Amrinone is a non-glycoside positive inotropic agent with an inhibitory effect on a cyclic adenosine monophosphate (AMP) phosphodiesterase isoenzyme. In the present study, we examined the immunosuppressive action of amrinone, since
Y Furukawa +6 more
core +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016 Leishmaniasis and Chagas disease are neglected parasitic diseases endemic in developing countries; efforts to find new therapies remain a priority. Calcium channel blockers (CCBs) are drugs in clinical use for hypertension and other heart pathologies. Based on previous reports about the antileishmanial activity of dihydropyridine‐CCBs, this work aimed ...
Juliana Quero Reimão +4 more
wiley +1 more source