Results 21 to 30 of about 1,296 (182)

Advanced heart failure: guideline‐directed medical therapy, diuretics, inotropes, and palliative care

ESC Heart Failure, Volume 9, Issue 3, Page 1507-1523, June 2022., 2022
Abstract Heart failure (HF) is a major cause of mortality, hospitalizations, and reduced quality of life and a major burden for the healthcare system. The number of patients that progress to an advanced stage of HF is growing. Only a limited proportion of these patients can undergo heart transplantation or mechanical circulatory support. The purpose of
Daniela Tomasoni, Julie K.K. Vishram‐Nielsen, Matteo Pagnesi, Marianna Adamo, Carlo Mario Lombardi, Finn Gustafsson, Marco Metra   +6 more
wiley   +1 more source

Semiparametric Panel Count Model, With Applications to Signal Detection in Post-Market Drug Surveillance Systems. [PDF]

Stat Med
ABSTRACT Panel count data occurs in a wide variety of applications, ranging from biomedical research to business, such as the number of accidents, product defects, and insurance claims. For such data under the FDA investigation, millions of reported adverse events (AEs) associated with thousands of drugs are monitored in the post‐market drug safety ...
Zhou Y, Yuan A, Tan M.
europepmc   +2 more sources

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Advanced Therapeutics, Volume 5, Issue 2, February 2022., 2022
Alkaline phosphatase has been an endogenous partner for phosphate prodrugs for decades. More recently, it has been utilized as a reliable partner for enzyme‐responsive drug nanocarriers and diagnostic systems constructed from novel phosphate‐functionalized biomaterials.
Bao Le‐Vinh, Zeynep Burcu Akkuş‐Dağdeviren, Nguyet‐Minh Nguyen Le, Imran Nazir, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Hepatoprotection of Paederia scandens (Lour.) Merr. on Acetaminophen‐Related Hepatic Injury Rats by 1H‐NMR‐Based Metabonomics Coupled with Network Pharmacology

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Background. Acetaminophen‐related hepatic injury (ARHI) is a kind of acute hepatic injury caused by overdosing acetaminophen, which is mainly related to toxic metabolite production, oxidative stress, and mitochondrial dysfunction. The extract of Paederia scandens (Lour.) Merr.
Chao-Ling Tang, Ning Ma, Wan-Ying Sun, Wei Wang, Li-Peng Zhu, Rui-Qi Wang, Jie-Yan Liu, Xiao-Po Zhang, Isac Medeiros   +8 more
wiley   +1 more source

Application of Esmolol to Control Heart Rate and Artificial Intelligence Reconstruction Analysis for Rapid Zero‐Cooperation Emergency Coronary CTA

Journal of Healthcare Engineering, Volume 2022, Issue 1, 2022., 2022
Objective. To investigate a rapid and effective method for the examination of coronary CTA in emergency patients requiring coronary CTA examination, who have faster heart rate (≧80 bpm) or cannot cooperate with the examination due to the inability of breath holding at poor physical conditions. Methods.
Chenfeng Ni, Lei Pei, Miaoping Zhou, Xiaolong He, Kalidoss Rajakani   +4 more
wiley   +1 more source

Circulating growth differentiation factor‐15 as a novel biomarker in heart transplant

ESC Heart Failure, Volume 8, Issue 4, Page 3279-3285, August 2021., 2021
Abstract Aims This study aimed to examine (i) whether circulating growth differentiation factor‐15 (GDF‐15) is associated with acute cellular cardiac allograft rejection (ACR); (ii) a longitudinal trend of GDF‐15 after heart transplantation; and (iii) the prognostic value of GDF‐15 in predicting a composite outcome of severe primary graft dysfunction ...
Nithi Tokavanich, Supanee Sinphurmsukskul, Narisorn Kongruttanachok, Kanokwan Thammanatsakul, Supaporn Sritangsirikul, Aekarach Ariyachaipanich, Pat Ongcharit, Sarawut Siwamogsatham, Smonporn Boonyaratavej, Sarinya Puwanant   +9 more
wiley   +1 more source

Post‐transplant inotrope score is associated with clinical outcomes after adult heart transplantation

Clinical Transplantation, Volume 35, Issue 8, August 2021., 2021
Abstract Background Inotrope score has been proposed as a marker of clinical outcome after adult heart transplantation (HTx) but is rarely used in practice. Methods Inotrope score during the first 48 h after HTx was calculated in 81 patients as: dopamine + dobutamine + amrinone + milrinone (dose × 15) + epinephrine (dose × 100) + norepinephrine (dose × 
Constantijn S. Venema, Michiel E. Erasmus, Massimo Mariani, Adriaan A. Voors, Kevin Damman   +4 more
wiley   +1 more source

High‐content screening identifies inhibitors of oxidative stress‐induced parthanatos: cytoprotective and anti‐inflammatory effects of ciclopirox

British Journal of Pharmacology, Volume 178, Issue 5, Page 1095-1113, March 2021., 2021
Background and Purpose Excessive oxidative stress can induce PARP1‐mediated programmed necrotic cell death, termed parthanatos. Inhibition of parthanatos may be therapeutically beneficial in a wide array of diseases associated with tissue injury and inflammation. Our goal was to identify novel molecules inhibiting parthanatos.
Zsolt Regdon, Máté A. Demény, Katalin Kovács, Zoltán Hajnády, Máté Nagy‐Pénzes, Edina Bakondi, Alexandra Kiss, Csaba Hegedűs, László Virág   +8 more
wiley   +1 more source

Discovery and Validation of an Epithelial‐Mesenchymal Transition‐Based Signature in Gastric Cancer by Genomics and Prognosis Analysis

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Objective. Epithelial‐mesenchymal transition (EMT) exerts a key function in cancer initiation and progression. Herein, we aimed to develop an EMT‐based prognostic signature in gastric cancer. Methods. The gene expression profiles of gastric cancer were obtained from TCGA dataset as a training set and GSE66229 and GSE84437 datasets as validation sets ...
Huiyong Xu, Huilai Wan, Maoshu Zhu, Lianghua Feng, Hui Zhang, Fengbing Su, Rajkumar Kottayasamy Seenivasagam   +6 more
wiley   +1 more source

Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin [PDF]

, 2009
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force.
Torres, Nuria Albet,, Geeves, M., Barman, T., Barman, Tom, Bloemink, Marieke J, Schmitz, S, Piperio, C., Lionne, C, Albet-Torres, Nuria, Schmitz, Stephan, Bloemink, Marieke J., Golker, K., Bloemink, M., Candau, R., Veigel, C., Herrmann, Christian, Albet-Torres, N., Geeves, Michael A, Mansson, A., Mansson, Alf, Herrmann, C., Månsson, Alf,, Piperio, C, Candau, Robin, Geeves, Michael A., Herrmann, C, Frölander, Kerstin,, Schmitz, S., Candau, R, Piperio, Claudia, Lionne, Corinne, Veigel, Claudia, Bloemink, MJ, Geeves, MA, Frolander, K., Lionne, C., Golker, Kerstin, Frolander, Kerstin, Veigel, C, Golker, Kerstin,, Barman, T   +40 more
core   +1 more source