Results 1 to 10 of about 12,396 (213)

Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons

Molecular Metabolism, 2022
Objective: The behavioral mechanisms and the neuronal pathways mediated by amylin and its long-acting analog sCT (salmon calcitonin) are not fully understood and it is unclear to what extent sCT and amylin engage overlapping or distinct neuronal ...
Lavinia Boccia, Tito Borner, Misgana Y. Ghidewon, Patricia Kulka, Chiara Piffaretti, Sarah A. Doebley, Bart C. De Jonghe, Harvey J. Grill, Thomas A. Lutz, Christelle Le Foll   +9 more
doaj   +2 more sources

The association of circulating amylin with β‐amyloid in familial Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction This study assessed the hypothesis that circulating human amylin (amyloid‐forming) cross‐seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD).
Han Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Donna M. Wilcock, Larry B. Goldstein, Rita Guerreiro, José Brás, Angela J. Hanson, Suzanne Craft, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, AESG, Florin Despa   +21 more
doaj   +2 more sources

Development of Cagrilintide, a Long-Acting Amylin Analogue

Journal of Medicinal Chemistry, 2021
A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort. The amylin analogue pramlintide is commercially available for diabetes treatment as an adjunct to
Ulrich Sensfuss, Claus Bekker Jeppesen, Charlotta Dornonville de la Cour   +2 more
exaly   +2 more sources

Creating the amylin story.

Appetite, 2022
This paper is based on a presentation given at the Annual Meeting of the Society for the Study of Ingestive Behavior in July 2021 and provides a personal view on some of the milestones in the discovery of amylin as a constituent of pancreatic islet ...
T. Lutz
semanticscholar   +3 more sources

Amylin Analog Pramlintide Induces Migraine‐like Attacks in Patients

Annals of Neurology, 2021
Migraine is a prevalent and disabling neurological disease. Its genesis is poorly understood, and there remains unmet clinical need. We aimed to identify mechanisms and thus novel therapeutic targets for migraine using human models of migraine and ...
Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Christopher S Walker   +2 more
exaly   +2 more sources

Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells

Pharmaceutics, 2021
In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper/metformin ...
Terenzio Congiu, Mawadda Alghrably, Abdul-Hamid Emwas, Lukasz Jaremko, Joanna I. Lachowicz, Marco Piludu, Monica Piras, Gavino Faa, Giuseppina Pichiri, Mariusz Jaremko, Pierpaolo Coni   +10 more
doaj   +2 more sources

Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice

Nature Communications, 2022
Social animals actively engage in contact with conspecifics and experience stress upon isolation. However, the neural mechanisms coordinating the sensing and seeking of social contacts are unclear.
Kansai Fukumitsu, Thomas J Mchugh, Kumi O Kuroda   +2 more
exaly   +2 more sources

Amylin brain circuitry.

Peptides, 2020
Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount.
Lavinia Boccia, Salome Gamakharia, B. Coester, L. Whiting, T. Lutz, C. Le Foll   +5 more
semanticscholar   +3 more sources

Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia

The Journal of Headache and Pain
Background The upper cervical dorsal root ganglia (DRG) are important for the transmission of sensory information associated with the back of the head and neck, contributing to head pain.
Tayla A. Rees, Zoe Tasma, Michael L. Garelja, Simon J. O’Carroll, Christopher S. Walker, Debbie L. Hay   +5 more
doaj   +2 more sources

Amylin as a Future Obesity Treatment

Journal of Obesity & Metabolic Syndrome, 2021
Obesity is defined as abnormal or excessive fat accumulation that contributes to detrimental health impacts. One-third of the population suffers from obesity, and it is important to consider obesity as a chronic disease requiring chronic treatment ...
Babak Dehestani, Nicholas RS Stratford, Carel W le Roux   +2 more
doaj   +2 more sources