SATB1 Exhibits a Protective Role in HAmylin-Oligomer-Induced Neuronal Damage and Cognition Decline. [PDF]
CNS Neurosci TherIn this study, bilateral hippocampal injections of hAmylin oligomers induced an obvious cognition decline in mice, along with upregulation of SATB1 in the mouse hippocampus. In hAmylin‐induced mice, SATB1 knockdown (KD) further aggravated the above changes.
Xing Y +5 more
europepmc +2 more sources
Structural insight into selectivity of amylin and calcitonin receptor agonists
Nature Chemical Biology, 2023 Amylin receptors (AMYRs), heterodimers of the calcitonin receptor (CTR) and one of three receptor activity-modifying proteins, are promising obesity targets.
Jianjun Cao +14 more
semanticscholar +1 more source
Mediators of Amylin Action in Metabolic Control
Journal of Clinical Medicine, 2022 Amylin (also called islet amyloid polypeptide (IAPP)) is a pancreatic beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli.
C. Boyle, Yi Zheng, T. Lutz
semanticscholar +1 more source
Inter-species cross-seeding: stability and assembly of rat-human amylin aggregates. [PDF]
PLoS ONE, 2014 Diseases such as type 2 diabetes, Alzheimer's and Parkinson's share as common feature the accumulation of mis-folded disease-specific protein aggregates into fibrillar structures, or plaques.
Workalemahu M Berhanu +1 more
doaj +1 more source
The assessment value of pathological condition of serum adiponectin and amylin in primary osteoporosis and its correlation analysis with bone metabolism indexes [PDF]
Journal of Medical Biochemistry, 2023 Background: This paper explores the assessment value of pathological condition of serum adiponectin (APN) and amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes.
Wang Xiao Jie +5 more
doaj +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Cagrilintide is a novel long-acting amylin receptor agonist, which has shown a potent induction of weight loss. Interestingly, cagrilintide is a Dual Amylin and Calcitonin Receptor Agonist (DACRA) derived from an amylin backbone.
A. T. Larsen +6 more
semanticscholar +1 more source
MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2. [PDF]
PLoS ONE, 2011 BackgroundAmylin is the most abundant component of islet amyloid implicated in the development of type 2 diabetes. Plasma amylin levels are elevated in individuals with obesity and insulin resistance.
Kun Cai +8 more
doaj +1 more source
Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat
Frontiers in Endocrinology, 2021 The hormones amylin and calcitonin interact with receptors within the same family to exert their effects on the human organism. Calcitonin, derived from thyroid C cells, is known for its inhibitory effect on osteoclasts.
David S Mathiesen +4 more
semanticscholar +1 more source
Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity
Cells, 2018 Amylin, (or islet amyloid polypeptide; IAPP), a 37-amino acid peptide hormone, is released in response to nutrients, including glucose, lipids or amino acids. Amylin is co-stored and co-secreted with insulin by pancreatic islet β-cells.
Yoshimitsu Kiriyama, Hiromi Nochi
doaj +1 more source
Amylin Protein Expression in the Rat Brain and Neuro-2a Cells
International Journal of Molecular Sciences, 2022 The localization and expression of amylin protein in the rodent brain and mouse neuroblastoma Neuro-2a (N2a) are less widely known. Thus, this study investigated the expression distribution of amylin in the rat brain and N2a treated with steroid hormones.
Y. Yoo, E. Jung, E. Jeung, B. Jo, S. Joo
semanticscholar +1 more source