Results 131 to 140 of about 118,464 (350)

Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons. [PDF]

Biomedicines, 2023
Melo de Farias AR, Pelletier A, Iohan LCC, Saha O, Bonnefond A, Amouyel P, Delahaye F, Lambert JC, Costa MR.   +8 more
europepmc   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Beta-amyloid oligomers: recent developments

Biomolecular Concepts, 2011
Recent studies point to a critical role of soluble β-amyloid oligomers in the pathogenesis of one of the most common neurodegenerative diseases, Alzheimer's disease (AD).
Borutaite Vilmante, Morkuniene Ramune, Valincius Gintaras   +2 more
doaj   +1 more source

A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site. [PDF]

Toxins (Basel), 2023
Futai E, Kawasaki H, Sato S, Daoudi K, Hidaka M, Tomita T, Ogawa T.   +6 more
europepmc   +1 more source

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death [PDF]

, 1995
Mark Rj, K. Hensley, DA Butterfield, MP Mattson   +3 more
openalex   +1 more source

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, EarlyView.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

Alternative Method to Detect Neuronal Degeneration and Amyloid β Accumulation in Free-Floating Brain Sections With Fluoro-Jade

ASN Neuro, 2018
Fluoro-Jade is a fluorescein-derived fluorochrome which specifically binds to damaged neurons. Due to this characteristic, it is commonly used for the histochemical detection and quantification of neurodegeneration in mounted brain sections.
Irene L. Gutiérrez, Marta González-Prieto, Borja García-Bueno, Javier R. Caso, Juan C. Leza, José L. M. Madrigal   +5 more
doaj   +1 more source

Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency. [PDF]

Mol Genet Metab Rep, 2023
Rahhal S, Farmer C, Thurm A, Wassif CA, Cawley NX, Perreault J, Dang Do A, Bianconi S, Hannah-Shmouni F, Guthrie W, Cubit LS, Miller JS, Sutton VR, Koeberl D, Porter FD.   +14 more
europepmc   +1 more source

Peptide Sequence Programmed Piezoelectric Response by Supramolecular Self‐Assembly

Advanced Science, EarlyView.
In this study, hydrophobic tripeptides are explored as building blocks for stable piezoelectric crystals. Tripeptides with phenylalanine at the central position self‐assembled into uniform, thermally stable crystals. Piezoresponse force microscopy reveals a high effective piezoelectric coefficient of 24.0 pC N−1, attributed to asymmetric molecular ...
Xuejiao Yang, Shuaijie Liu, Honglei Lu, Yuehui Wang, Hongyue Zhang, Wei Ji, Huaimin Wang   +6 more
wiley   +1 more source

Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood-Brain Barrier Endothelium. [PDF]

Mol Pharmacol, 2023
Wang Z, Sharda N, Omtri RS, Li L, Kandimalla KK.   +4 more
europepmc   +1 more source