Results 131 to 140 of about 120,218 (348)

A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site. [PDF]

Toxins (Basel), 2023
Futai E, Kawasaki H, Sato S, Daoudi K, Hidaka M, Tomita T, Ogawa T.   +6 more
europepmc   +1 more source

Molecular Details of the Apolipoprotein E and the Amyloid Beta Peptide Interaction: Analysis of a Potential Binding Site Responsible for ApoE4 Misfolding [PDF]

, 2010
Alex Perálvarez‐Marín, Jinghui Luo, Jean‐Didier Maréchal, Sebastian K.T.S. Wärmländer, Astrid Gräslund   +4 more
openalex   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Beta-amyloid oligomers: recent developments

Biomolecular Concepts, 2011
Recent studies point to a critical role of soluble β-amyloid oligomers in the pathogenesis of one of the most common neurodegenerative diseases, Alzheimer's disease (AD).
Borutaite Vilmante, Morkuniene Ramune, Valincius Gintaras   +2 more
doaj   +1 more source

Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency. [PDF]

Mol Genet Metab Rep, 2023
Rahhal S, Farmer C, Thurm A, Wassif CA, Cawley NX, Perreault J, Dang Do A, Bianconi S, Hannah-Shmouni F, Guthrie W, Cubit LS, Miller JS, Sutton VR, Koeberl D, Porter FD.   +14 more
europepmc   +1 more source

Retraction: Protective Effect of HSP90 on Neuronal Cell Death-induced by beta-Amyloid Peptide

, 2020
Hyun Jung Lee, Do Hee Kim, Ok Hyun Kim, Yoon Hee Chung, Kyung Yong Kim, Sung Soo Kim, Won Bok Lee   +6 more
openalex   +1 more source

Pyroglutamylated Amyloid-Beta Peptide Reverses Cross Beta-Sheets by a Prion-Like Mechanism [PDF]

, 2014
Jason O. Matos, Greg Goldblatt, Suren A. Tatulian   +2 more
openalex   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Alternative Method to Detect Neuronal Degeneration and Amyloid β Accumulation in Free-Floating Brain Sections With Fluoro-Jade

ASN Neuro, 2018
Fluoro-Jade is a fluorescein-derived fluorochrome which specifically binds to damaged neurons. Due to this characteristic, it is commonly used for the histochemical detection and quantification of neurodegeneration in mounted brain sections.
Irene L. Gutiérrez, Marta González-Prieto, Borja García-Bueno, Javier R. Caso, Juan C. Leza, José L. M. Madrigal   +5 more
doaj   +1 more source

Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood-Brain Barrier Endothelium. [PDF]

Mol Pharmacol, 2023
Wang Z, Sharda N, Omtri RS, Li L, Kandimalla KK.   +4 more
europepmc   +1 more source