Results 261 to 270 of about 118,464 (350)

Conformational behavior and aggregation of amyloid beta peptides

, 2008
Raghunadha Reddy Burri
openalex   +1 more source

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non‐Human Primates

PROTEOMICS, EarlyView.
ABSTRACT The β‐secretase BACE1 (β‐site amyloid precursor (APP) cleaving enzyme 1) is a major drug target for Alzheimer's disease (AD), as it catalyzes the first step in amyloid β (Aβ) generation, but has additional substrates and functions, in particular in the brain.
Sarah K. Tschirner, Andree Schmidt, Mana Ito, Kana Hyakkoku, Akimasa Yoshimura, Stephan A. Müller, Naotaka Horiguchi, Stefan F. Lichtenthaler   +7 more
wiley   +1 more source

Probing Early α‐Synuclein Oligomers: Insights Into Aggregation Pathways of NACore and preNAC Segments Probed by Trapped Ion‐Mobility Mass Spectrometry and Fluorescence Spectroscopy

PROTEOMICS, EarlyView.
ABSTRACT Misfolding and aggregation of α‐Synuclein (α‐Syn) play a central role in Parkinson's disease (PD), with oligomeric intermediates implicated as key toxic species. Here, we investigate the aggregation of two α‐Syn segments, the NACore (68GAVVTGVTAVA78, WT‐PD1) and the preNAC region (47GVVHGVATVA56, WT‐PD2), using high‐resolution trapped ion ...
Agathe Depraz Depland, Stephanie Mikromanolis, Iuliia Stroganova, Anouk M. Rijs   +3 more
wiley   +1 more source

Designing novel peptides with amyloid-<i>β</i> binding and clearance potential using BiLSTM and molecular dynamics. [PDF]

Front Artif Intell
Yata VK, Das OP, Dansana J, Gadtya A, Meher BR, Bukke SPN, Kolliputi N.   +6 more
europepmc   +1 more source

In Vitro Characterization of Unmodified and Pyroglutamylated Alzheimer's Amyloid beta peptide

, 2014
Jason O. Matos
openalex   +1 more source

Amyloid-ß Acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2 [PDF]

Alifragis, P, Austen, BM, Beesley, PW, Empson, RM, Russell, CL, Semerdjieva, S   +5 more
core  

Non‐Targeted Analysis of Extracellular Vesicle‐Enriched Plasma Proteome Between Early and Late Rugby Playing Career

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Purpose Rugby players experience high‐impact collisions, potentially increasing their risk of neurodegenerative conditions. This study investigates whether the plasma proteome of extracellular vesicles (EV) provides biomarkers to indicate differential risk associated with a rugby career.
Abhishek Jagan, Yusuke Nishimura, Tim Donnovan, Jatin G. Burniston   +3 more
wiley   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons

, 2013
Saak V. Ovsepian, Inga Antyborzec, Valerie B. O’Leary, László Záborszky, Jochen Herms, J. Oliver Dolly   +5 more
openalex   +1 more source

Beyond Pathology: α‐Synuclein Homeostasis and Three Principles to Guide Research

Movement Disorders Clinical Practice, EarlyView.
Alberto J. Espay, Andrew J. Lees
wiley   +1 more source