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Alzheimer's Disease and the Amyloid-β Peptide [PDF]

Journal of Alzheimer's Disease, 2010
Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been puzzled by the weak to nonexistent correlation between the amount of neuritic plaque pathology in the human brain and the degree of clinical dementia.
Murphy M. Paul, LeVine, III Harry
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Natural human antibodies to amyloid beta peptide

Autoimmunity Reviews, 2008
Properties of human, natural anti-Abeta antibodies and commercially available intravenous immunoglobulin (IVIg) have been examined in light of the beneficial effects of passive immunotherapy with IVIg for patients with mild to moderate Alzheimer's disease (AD).
Paul, Szabo, Norman, Relkin, Marc E, Weksler   +2 more
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Diversity of amyloid beta peptide actions

Reviews in the Neurosciences
Abstract Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number of incurable diseases. One of the most known amyloid diseases is Alzheimer’s disease (AD). Traditionally, amyloidogenic beta peptides Aβ40 and Aβ42 (Aβs) are considered as main causes of AD and the foremost targets in AD fight.
Sona Mardanyan, Svetlana Sharoyan, Alvard Antonyan   +2 more
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Protection against amyloid beta peptide toxicity by zinc

Brain Research, 1999
Zinc (Zn) is an essential element in normal development and biology, although it is toxic at high concentrations. Recent studies show that Zn at high concentrations accelerates aggregation of amyloid beta peptide (Abeta), the major component of senile plaques in Alzheimer's disease (AD).
M A, Lovell, C, Xie, W R, Markesbery
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Effect of ferric citrate on amyloid‐beta peptides behavior

Biopolymers, 2018
AbstractAmyloid beta (Aβ) aggregation and oxidative stress are two of the central events in Alzheimer's Disease (AD). Both these phenomena can be caused by the interaction of Aβ with metal ions. In the last years the interaction between ZnII, CuII, and Aβ was much studied, but between iron and Aβ it is still little known.
Galante D, Cavallo E, Perico A, D'Arrigo C   +3 more
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Sequestration of amyloid beta-peptide.

Annals of the New York Academy of Sciences, 1993
Amyloid beta-protein, or beta/A4, is a 4-kilodalton peptide that forms poorly soluble extracellular depositions of amyloid in brains and leptomeninges of patients with Alzheimer's disease (AD), Down's syndrome (DS), and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D).
D, Goldgaber, A I, Schwarzman, R, Bhasin, L, Gregori, D, Schmechel, A M, Saunders, A D, Roses, W J, Strittmatter   +7 more
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Intracellular biology of Alzheimer's disease amyloid beta peptide

European Archives of Psychiatry and Clinical Neuroscience, 1999
Strong evidence links excess production of a small peptide and the pathogenesis of Alzheimer's disease (AD). Originally this peptide, beta-amyloid 42 (Abeta42), was assumed to be released by a pathogenic event; it is now well established that Abeta42 is released from cells during normal cellular metabolism of the Alzheimer amyloid precursor protein ...
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In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides

2012
The amyloid beta Ab(1-40) and Ab(1-42) peptides are the main components of the fibrillar plaques characteristically found in the brains affected by Alzheimer's disease. Fibril formation has been thoroughly studied in vitro using synthetic amyloid peptides and has been described to be a nucleation dependent polymerization process.
Núria, Benseny-Cases, Oksana, Klementieva, Josep, Cladera   +2 more
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Radiolabeling of Amyloid-β Peptides

2005
Nowadays, a wide variety of protocols for labeling proteins is available. However, radiolabeling remains one of the most powerful, sensitive and accurate methods to trace and quantitate proteins. Additionally, radiolabeling techniques are steadily gaining importance for diagnosis and treatment in nuclear medicine.
Miguel, Calero, Jorge, Ghiso
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Brain membrane cholesterol domains, aging and amyloid beta-peptides

Neurobiology of Aging, 2002
Lipids are essential for the structural and functional integrity of membranes. Membrane lipids are not randomly distributed but are localized in different domains. These domains consist of the exofacial and cytofacial leaflets, cholesterol pools, annular lipids, and lipid rafts.
W Gibson, Wood, Friedhelm, Schroeder, Urule, Igbavboa, Nicolai A, Avdulov, Svetlana V, Chochina   +4 more
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