Results 291 to 300 of about 85,510 (321)

Differential effects of amyloid-beta peptide aggregation status on in vivo retinal neurotoxicity

, 2010
Helena Watts, Pjb Anderson, Daqing Ma, K.L. Philpott, Shih-His Jen, Martin J. Croucher, L.S. Jen, Steve Gentleman   +7 more
openalex   +2 more sources

Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

ChemistryOpen, EarlyView.
Tau protein aggregation and fibrillation have been examined in relationship to three metal ions in this study. The research was conducted to see the effects of Zn2+, Cu2+ and Fe3+ ions at different concentrations on tau′s conformation, cytotoxicity in SH‐SY5Y cells, and free thiol levels.
Mahzad Irandoust, Afrooz Anbaraki, Zahra Dindar, Atiyeh Ghasemi, Ali Akbar Saboury, Saeed Rayati, Arefeh Seyedarabi   +6 more
wiley   +1 more source

Rationally Designed Pentapeptide Analogs of Aβ19-23 Fragment as Potent Inhibitors of Aβ42 Aggregation. [PDF]

Molecules
Baravkar SB, Lu Y, Zhao Q, Peng H, Zhou W, Hong S.   +5 more
europepmc   +1 more source

Determination of the Major Bioactive Component of Silybum marianum in Nutricosmetics by a HPLC Method With Amperometric Detection and UAE Pretreatment

Phytochemical Analysis, EarlyView.
ABSTRACT Introduction Nutricosmetics derived from Silybum marianum, known for their anti‐inflammatory and hepatoprotective properties, necessitate accurate quantification of silybin, a key bioactive component. Objectives This study aims to develop a novel high‐performance liquid chromatography (HPLC) method with amperometric detection (HPLC‐ECD) for ...
Lucía Abad‐Gil, M. Jesús Gismera, M. Teresa Sevilla, Jesús R. Procopio   +3 more
wiley   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Massive mutagenesis reveals an incomplete amyloid motif in Bri2 that turns amyloidogenic upon C-terminal extension. [PDF]

Proc Natl Acad Sci U S A
Martín M, Bolognesi B.
europepmc   +1 more source

Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus. [PDF]

Open Med (Wars)
Li G, Zhang D.
europepmc   +1 more source

Critical micellar concentration determination of pure phospholipids and lipid‐raft and their mixtures with cholesterol

Proteins: Structure, Function, and Bioinformatics, EarlyView.
Abstract Phospholipids in biological membranes establish a chemical equilibrium between free phospholipids in the aqueous phase (CMC) and self‐assembled phospholipids in vesicles, keeping the CMC constant. The CMC is different for each phospholipid, depends on the amount of cholesterol, and, according to the lipid‐chaperone hypothesis, controls the ...
Sofia Serravalle, Martina Pisano, Michele F. M. Sciacca, Nancy Salamone, Luciano Sicali, Giuseppe Mazzara, Luca Costa, Carmelo La Rosa   +7 more
wiley   +1 more source

Structural and biochemical differences between non-catalytic and catalytic antibodies. [PDF]

MAbs
Uda T, Kato R, Shigeta Y, Hirota S, Kobayashi J, Yoshida H, Tsuyuguchi M, Hengphasatporn K, Tsujita M, Taguchi H, Hifumi E.   +10 more
europepmc   +1 more source