Results 291 to 300 of about 120,218 (348)
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Amyloid beta peptides electrochemistry: A review
Current Opinion in Electrochemistry, 2022Abstract Alzheimer disease is a progressive age-related neurodegenerative disorder estimated to affect up to 107 million people by 2050, its pathology is associated with the dysfunction of the amyloid beta (Aβ) peptide mechanism, among others. Electrochemical methods were successfully applied for Aβ electrochemical characterisation and have received ...
Ana-Maria Chiorcea-Paquim +1 more
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Cholesterol Trafficking and Amyloid Beta Peptides
Pharmacopsychiatry, 2003Currently, there is much interest in the association between cholesterol and Alzheimer's disease. An especially important aspect of this association is the relationship between amyloid beta-peptide (Abeta) and cholesterol that can be described as a reciprocal process.
W G, Wood, U, Igbavboa
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Neprilysin and Amyloid Beta Peptide Degradation
Current Alzheimer Research, 2008Neprilysin is a zinc metalloendopeptidase with relatively broad substrate specificity. The enzyme is localized to the plasma membrane of cells where it can function to degrade extracellular peptides. Structural studies show that neprilysin preferentially cleaves peptides on the amino side of hydrophobic amino acids.
Louis B, Hersh, David W, Rodgers
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Cholesterol Modulates Amyloid Beta-peptide’s Membrane Interactions
Pharmacopsychiatry, 2003The causal relationship between amyloid beta-peptide (Abeta) deposition and Alzheimer's disease (AD)-specific neuropathological lesions such as neurodegeneration and cortical atrophy is still not known. Mounting evidence points to alterations in cholesterol homeostasis occurring in AD brain that are probably linked to cerebral Abeta pathology ...
Gunter P, Eckert +4 more
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Amyloid beta peptides and glutamatergic synaptic dysregulation
Experimental Neurology, 2008Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of glutamatergic synaptic ...
Kodeeswaran, Parameshwaran +2 more
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