Results 1 to 10 of about 94,035 (378)

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. [PDF]

Proceedings of the National Academy of Sciences, 1989
We have analyzed the modulation of amyloid beta-protein precursor (APP) gene expression in human umbilical vein endothelial cells (HUVEC). The level of the APP mRNA transcripts increased as HUVEC reached confluency. In confluent culture the half-life of the APP mRNA was 4 hr.
D. C. Gajdusek, Dmitry Goldgaber, Timothy Hla, Robert J. Donnelly, H W Harris, J S Jacobsen, Michael P. Vitek, T Maciag   +7 more
openaire   +4 more sources

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices. [PDF]

Proceedings of the National Academy of Sciences, 1993
Proteolytic processing of the beta-amyloid protein precursor (APP) is regulated by cell-surface receptors. To determine whether neurotransmitter release in response to neuronal activation regulates APP processing in brain, we electrically depolarized superfused rat hippocampal slices and measured soluble APP derivatives released into the superfusate ...
Roger Nitsch, Steven A. Farber, Richard J. Wurtman, John H. Growdon   +3 more
openaire   +5 more sources

Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor. [PDF]

Journal of Biological Chemistry, 1994
The amyloid beta-protein (A beta) and protease nexin-2/amyloid beta-protein precursor (PN-2/A beta PP) are major constituents of senile plaques and cerebrovascular deposits in individuals with Alzheimer's disease and related disorders. It has been suggested that the coagulation protease thrombin may process A beta PP in a manner leading to the ...
W E Van Nostrand, Frances M. Donovan, Susan M. Saporito-irwin, J Davis-Salinas, Dennis D. Cunningham   +4 more
openaire   +3 more sources

The Amyloid .BETA. Protein Precursor Mutations Linked to Familial Alzheimer's Disease Alter Processing in a Way That Fosters Amyloid Deposition.

The Tohoku Journal of Experimental Medicine, 1994
Normal processing of the amyloid beta protein precursor (BAPP) results in secretion of a soluble 4 kD protein essentially identical to the amyloid beta protein (A beta) that forms insoluble fibrillar deposits in Alzheimer's disease (AD). Strong evidence that amyloid deposition plays a critical role in the development of AD has come from the ...
Steven G. Younkin
openaire   +5 more sources

Alterations in the Processing of Platelet APP (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus. [PDF]

Neuropsychopharmacol Rep
Al-Kuraishy HM, Sulaiman GM, Mohammed HA, Dawood RA, Albuhadily AK, Al-Gareeb AI, Abomughaid MM, Klionsky DJ.   +7 more
europepmc   +2 more sources

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein.

PLoS ONE, 2022
The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer's disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and γ ...
Edward T Parkin, Jessica E Hammond, Lauren Owens, Matthew D Hodges   +3 more
doaj   +1 more source

Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

Molecules, 2022
The amyloid hypothesis of Alzheimer’s disease has long been the predominant theory, suggesting that Alzheimer’s disease is caused by the accumulation of amyloid beta protein (Aβ) in the brain, leading to neuronal toxicity in the central nervous system ...
Chen Ma, Fenfang Hong, Shulong Yang
doaj   +1 more source

CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. [PDF]

PLoS ONE, 2009
The linkages between neuroinflammation and Alzheimer's disease (AD) pathogenesis are well established. What is not, however, is how specific immune pathways and proteins affect the disease.
Tomomi Kiyota, Masaru Yamamoto, Huangui Xiong, Mary P Lambert, William L Klein, Howard E Gendelman, Richard M Ransohoff, Tsuneya Ikezu   +7 more
doaj   +1 more source

Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

Biology Open, 2021
The organic anion transporter Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the ...
Wayne M. Jepsen, Matthew De Both, Ashley L. Siniard, Keri Ramsey, Ignazio S. Piras, Marcus Naymik, Adrienne Henderson, Matthew J. Huentelman   +7 more
doaj   +1 more source

Platelet APP Processing: Is It a Tool to Explore the Pathophysiology of Alzheimer’s Disease? A Systematic Review

Life, 2021
The processing of the amyloid precursor protein (APP) is a critical event in the formation of amyloid plaques. Platelets contain most of the enzymatic machinery required for APP processing and correlates of intracerebral abnormalities have been ...
Manuel Glauco Carbone, Giovanni Pagni, Claudia Tagliarini, Donatella Marazziti, Nunzio Pomara   +4 more
doaj   +1 more source