Results 161 to 170 of about 4,375,511 (236)

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Presenilin-1 Affects Melanoma Cell Behavior in an Amyloid Precursor Protein-Rich, Alzheimer's Disease-like, Microenvironment. [PDF]

Int J Mol Sci
Untiveros G, St Germain R, Barrington B, Kujawa SA, Prakapenka AV, Strizzi L.   +5 more
europepmc   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Neuroinflammation, Pericyte Dysfunction, and Alzheimer's Disease-Associated Gene Expression and Pathway Activation in the Brain of SARS-CoV-2-Infected Mice. [PDF]

Viruses
Lawal AO, Jacob IB, Karnik V, Fan H, Thangamani S, Massa PT, Wang G.   +6 more
europepmc   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 Overexpression Abrogates ST6GAL1 Mediated Rectal Cancer Chemoradiation Resistance. [PDF]

Cancer Genomics Proteomics
Beamon TC, Mohammed ED, Lever JMP, Irwin RK, Somasundaram V, Huang F, McLeod MC, Hardiman KM.   +7 more
europepmc   +1 more source

Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling, Lena Marth, Katja Sandkühler, Anna Stockbauer, Elisabeth Wlasich, Alexander Jäck, Olivia Wagemann, Julia Kustermann, Steffen Halbgebauer, Hayrettin Tumani, Günter Höglinger, Johannes Levin   +11 more
wiley   +1 more source

The beneficial properties of CBDA in diet-induced neuroinflammation. [PDF]

Inflammopharmacology
Konstantynowicz-Nowicka K, Opęchowska A, Domalewski M, Zabielska-Kaczorowska M, Bogucka A, Lipiński M, Harasim-Symbor E, Chabowski A.   +7 more
europepmc   +1 more source

A validated deep learning workflow for 3D quantification of amyloid plaques in cleared mouse brain

Journal of Microscopy, EarlyView.
Abstract Accurate quantification of amyloid plaque pathology is essential for understanding Alzheimer's disease (AD) progression and evaluating therapeutic interventions. Yet, conventional histology relies on sampling thin tissue sections and therefore incompletely captures three‐dimensional (3D) plaque distributions, introducing bias and limiting ...
Veronika Valova, Louise Cole, Neftali Flores Rodriguez, Filip Braet, Daniel M. Johnstone, Richard Harwood   +5 more
wiley   +1 more source

Comparison of amyloid and tau pathology in the small and large intestines of individuals with Alzheimer's disease, Parkinson's disease, and Dementia with Lewy bodies. [PDF]

MicroPubl Biol
Floden AM, Manocha GD, Frolov NI, Lerick AE, Combs CK.   +4 more
europepmc   +1 more source