Results 161 to 170 of about 168,658 (234)

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

Annual Review of Cell Biology, 1994
BIOCHEMICAL ANALYSES OF ALZHEIMER BRAIN LESIONS LEAD TO THE IDENTIFICATION OF A AND ITS PRECURSOR . . . . . . . . . . . . . . . . . . . 374 The Histopathology of Alzheimer's Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 374 Characterization of A and pp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
D. Selkoe
semanticscholar   +5 more sources

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Science, 1993
The 4-kilodalton amyloid βprotein (Aβ), which forms fibrillar deposits in Alzheimer's disease (AD), is derived from a large protein referred to as the amyloid β protein precursor (βAPP). Human neuroblastoma (M17) cells transfected with constructs expressing wild-type βAPP or a mutant, βAPP ΔNL , recently linked to ...
X D, Cai, T E, Golde, S G, Younkin
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Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications, 1989
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
D, Schubert, G, Cole, T, Saitoh, T, Oltersdorf   +3 more
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Genomic organization of the human-amyloid beta-protein precursor gene

Gene, 1990
Amyloid beta-protein (BP) deposited in Alzheimer brains is a cleavage product of a larger precursor (BPP). The BPP gene encodes three types of mRNA generated by alternative splicing, two of which contain the sequence encoding Kunitz-type serine-protease inhibitor (serpin).
S, Yoshikai, H, Sasaki, K, Doh-ura, H, Furuya, Y, Sakaki   +4 more
openaire   +3 more sources

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

Science, 1990
Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by extensive amyloid deposition in the small leptomeningeal arteries and cortical arterioles, which lead to an early death of those afflicted in their fifth or sixth decade ...
Van Broeckhoven, Christine, Haan, J., Bakker, E., Hardy, J.A., Vanhul, W., Wehrert, A., Vegter-Van der Vlis, M., Roos, R.A.C.   +7 more
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